Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.

Detalhes bibliográficos
Autor(a) principal: Soares, Milena Botelho Pereira
Data de Publicação: 2001
Outros Autores: Mota, Kátia N. Silva, Lima, Ricardo Santana de, Bellintani, Moema Cortizo, Pontes-de-Carvalho, Lain Carlos, Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5531
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Soares, Milena Botelho PereiraMota, Kátia N. SilvaLima, Ricardo Santana deBellintani, Moema CortizoPontes-de-Carvalho, Lain CarlosSantos, Ricardo Ribeiro dos2012-09-19T19:16:06Z2012-09-19T19:16:06Z2001SOARES, M.B. et al. Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. American Journal of Pathology, v. 159, n. 2, p. 703-709, Aug. 2001.0002-9440https://www.arca.fiocruz.br/handle/icict/5531engModulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilChronic chagasic cardiomyopathy (CChC) is characterized by an inflammatory reaction which may eventually lead to heart enlargement, arrythmia, and death. As described herein, interleukin-4-deficient mice mount increased specific T helper (Th) 1 immune responses when infected with Trypanosoma cruzi, as compared to wild-type mice. Interestingly, these mice had reduced parasitism and mortality and exacerbated inflammation in their hearts, demonstrating a clear dissociation between inflammation and parasite load. The modulation of these phenomena so as to maximize host and parasite survivals may depend on a fine balance between Th responses, in which a Th1 response will, on one hand, control parasitism and, on the other hand, enhance heart inflammation throughout the course of the infectionCardiomiopatia Chagásica/imunologiaInflamação/imunologiaInterleucina-4/fisiologiaParasitemia/imunologiaLinfócitos T Auxiliares-Indutores/imunologiaAnimaisCardiomiopatia Chagásica/genéticaCardiomiopatia Chagásica/patologiaImunidade Inata/genéticaImunidade Inata/imunologiaInflamação/patologiaInterleucina-4/deficiênciaInterleucina-4/genéticaAtivação LinfocitáriaCamundongosCamundongos Endogâmicos BALB CCamundongos KnockoutCamundongos NusMiocardite/genéticaMiocardite/imunologiaMiocardite/patologiaParasitemia/patologiaFatores de TempoTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares MB Modulation of chagasic....pdfSoares MB Modulation of chagasic....pdfapplication/pdf580115https://www.arca.fiocruz.br/bitstream/icict/5531/1/Soares%20MB%20Modulation%20of%20chagasic....pdff992a0e23e226382d2e2c19e63edd574MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5531/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTSoares MB Modulation of chagasic....pdf.txtSoares MB Modulation of chagasic....pdf.txtExtracted texttext/plain32048https://www.arca.fiocruz.br/bitstream/icict/5531/5/Soares%20MB%20Modulation%20of%20chagasic....pdf.txt01eec1797e7549f9bc169c779510b66cMD55THUMBNAILSoares MB Modulation of chagasic....pdf.jpgSoares MB Modulation of chagasic....pdf.jpgGenerated Thumbnailimage/jpeg2153https://www.arca.fiocruz.br/bitstream/icict/5531/4/Soares%20MB%20Modulation%20of%20chagasic....pdf.jpgee6064132172664f888814d5106f6775MD54icict/55312023-03-15 14:32:53.93oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
title Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
spellingShingle Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
Soares, Milena Botelho Pereira
Cardiomiopatia Chagásica/imunologia
Inflamação/imunologia
Interleucina-4/fisiologia
Parasitemia/imunologia
Linfócitos T Auxiliares-Indutores/imunologia
Animais
Cardiomiopatia Chagásica/genética
Cardiomiopatia Chagásica/patologia
Imunidade Inata/genética
Imunidade Inata/imunologia
Inflamação/patologia
Interleucina-4/deficiência
Interleucina-4/genética
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Camundongos Nus
Miocardite/genética
Miocardite/imunologia
Miocardite/patologia
Parasitemia/patologia
Fatores de Tempo
Trypanosoma cruzi
title_short Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
title_full Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
title_fullStr Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
title_full_unstemmed Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
title_sort Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
author Soares, Milena Botelho Pereira
author_facet Soares, Milena Botelho Pereira
Mota, Kátia N. Silva
Lima, Ricardo Santana de
Bellintani, Moema Cortizo
Pontes-de-Carvalho, Lain Carlos
Santos, Ricardo Ribeiro dos
author_role author
author2 Mota, Kátia N. Silva
Lima, Ricardo Santana de
Bellintani, Moema Cortizo
Pontes-de-Carvalho, Lain Carlos
Santos, Ricardo Ribeiro dos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Milena Botelho Pereira
Mota, Kátia N. Silva
Lima, Ricardo Santana de
Bellintani, Moema Cortizo
Pontes-de-Carvalho, Lain Carlos
Santos, Ricardo Ribeiro dos
dc.subject.decs.pt_BR.fl_str_mv Cardiomiopatia Chagásica/imunologia
Inflamação/imunologia
Interleucina-4/fisiologia
Parasitemia/imunologia
Linfócitos T Auxiliares-Indutores/imunologia
Animais
Cardiomiopatia Chagásica/genética
Cardiomiopatia Chagásica/patologia
Imunidade Inata/genética
Imunidade Inata/imunologia
Inflamação/patologia
Interleucina-4/deficiência
Interleucina-4/genética
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Camundongos Nus
Miocardite/genética
Miocardite/imunologia
Miocardite/patologia
Parasitemia/patologia
Fatores de Tempo
Trypanosoma cruzi
topic Cardiomiopatia Chagásica/imunologia
Inflamação/imunologia
Interleucina-4/fisiologia
Parasitemia/imunologia
Linfócitos T Auxiliares-Indutores/imunologia
Animais
Cardiomiopatia Chagásica/genética
Cardiomiopatia Chagásica/patologia
Imunidade Inata/genética
Imunidade Inata/imunologia
Inflamação/patologia
Interleucina-4/deficiência
Interleucina-4/genética
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Camundongos Nus
Miocardite/genética
Miocardite/imunologia
Miocardite/patologia
Parasitemia/patologia
Fatores de Tempo
Trypanosoma cruzi
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2012-09-19T19:16:06Z
dc.date.available.fl_str_mv 2012-09-19T19:16:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, M.B. et al. Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. American Journal of Pathology, v. 159, n. 2, p. 703-709, Aug. 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5531
dc.identifier.issn.none.fl_str_mv 0002-9440
identifier_str_mv SOARES, M.B. et al. Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. American Journal of Pathology, v. 159, n. 2, p. 703-709, Aug. 2001.
0002-9440
url https://www.arca.fiocruz.br/handle/icict/5531
dc.language.iso.fl_str_mv eng
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