Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil

Detalhes bibliográficos
Autor(a) principal: Pena, Geórgia das Graças
Data de Publicação: 2014
Outros Autores: Dutra, Miriam Santos, Oliveira, Andréa Gazzinelli Corrêa de, Oliveira, Rodrigo Corrêa de, Melendez, Gustavo Velasquez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9431
Resumo: Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materno-Infantil e Saude Publica. Belo Horizonte, MG, Brazil
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spelling Pena, Geórgia das GraçasDutra, Miriam SantosOliveira, Andréa Gazzinelli Corrêa deOliveira, Rodrigo Corrêa deMelendez, Gustavo Velasquez2015-02-04T16:55:30Z2015-02-04T16:55:30Z2014PENA, Geórgia das Graças et al. Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil. Ann Hum Genet, v. 78, n. 1, p. 40-9, 2014.0003-4800https://www.arca.fiocruz.br/handle/icict/943110.1111/ahg.12047.engWiley-BlackwellHeritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materno-Infantil e Saude Publica. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materno-Infantil e Saude Publica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materno-Infantil e Saude Publica. Belo Horizonte, MG, BrazilWe aimed to estimate the heritability and genetic correlation between glucose homeostasis and adiposity traits in a population in a rural community in Brazil. The Jequitinhonha Community Family Study cohort consists of subjects aged ≥18 years residing in rural areas in Brazil. The data on the following traits were assembled for 280 individuals (51.7% women): body mass index (BMI), body fat percentage, waist and mid-upper arm circumferences, triceps skinfold, conicity index, insulin, glucose, high-density lipoprotein cholesterol (HDLc), triglycerides and C-reactive protein. Extended pedigrees were constructed up to the third generation of individuals using the data management software PEDSYS. The heritability and genetic correlations were estimated using a variance component method. The age- and sex-adjusted heritability values estimated for insulin (h(2) = 52%), glucose (h(2) = 51%), HDLc (h(2) = 58%), and waist circumference (WC; h(2) = 49%) were high. Significantly adjusted genetic correlations were observed between insulin paired with each of the following phenotypes; (BMI; ρg = 0.48), WC (ρg = 0.47) and HDLc (ρg = -0.47). The homeostasis model assessment of insulin resistance (HOMA-IR) was genetically correlated with BMI (ρg = 0.53) and HDLc (ρg = -0.58). The adjusted genetic correlations between traits were consistently higher compared with the environmental correlations. In conclusion, glucose metabolism and adiposity traits are highly heritable and share common genetic effects with body adiposity traits.Adiposity/geneticsCross-Sectional StudiesGene-Environment InteractionObesity/geneticsQuantitative Trait, HeritableRural Populationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9431/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_036.pdf2014_036.pdfapplication/pdf165423https://www.arca.fiocruz.br/bitstream/icict/9431/2/2014_036.pdfad401969058946e7c0c25875fb6f9b6cMD52TEXT2014_036.pdf.txt2014_036.pdf.txtExtracted texttext/plain49671https://www.arca.fiocruz.br/bitstream/icict/9431/3/2014_036.pdf.txtdb5ee773dcdea062da420e8f63a44e91MD53icict/94312019-06-19 10:07:38.027oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:07:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
title Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
spellingShingle Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
Pena, Geórgia das Graças
Adiposity/genetics
Cross-Sectional Studies
Gene-Environment Interaction
Obesity/genetics
Quantitative Trait, Heritable
Rural Population
title_short Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
title_full Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
title_fullStr Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
title_full_unstemmed Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
title_sort Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
author Pena, Geórgia das Graças
author_facet Pena, Geórgia das Graças
Dutra, Miriam Santos
Oliveira, Andréa Gazzinelli Corrêa de
Oliveira, Rodrigo Corrêa de
Melendez, Gustavo Velasquez
author_role author
author2 Dutra, Miriam Santos
Oliveira, Andréa Gazzinelli Corrêa de
Oliveira, Rodrigo Corrêa de
Melendez, Gustavo Velasquez
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pena, Geórgia das Graças
Dutra, Miriam Santos
Oliveira, Andréa Gazzinelli Corrêa de
Oliveira, Rodrigo Corrêa de
Melendez, Gustavo Velasquez
dc.subject.en.pt_BR.fl_str_mv Adiposity/genetics
Cross-Sectional Studies
Gene-Environment Interaction
Obesity/genetics
Quantitative Trait, Heritable
Rural Population
topic Adiposity/genetics
Cross-Sectional Studies
Gene-Environment Interaction
Obesity/genetics
Quantitative Trait, Heritable
Rural Population
description Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materno-Infantil e Saude Publica. Belo Horizonte, MG, Brazil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-02-04T16:55:30Z
dc.date.available.fl_str_mv 2015-02-04T16:55:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PENA, Geórgia das Graças et al. Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil. Ann Hum Genet, v. 78, n. 1, p. 40-9, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9431
dc.identifier.issn.none.fl_str_mv 0003-4800
dc.identifier.doi.none.fl_str_mv 10.1111/ahg.12047.
identifier_str_mv PENA, Geórgia das Graças et al. Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil. Ann Hum Genet, v. 78, n. 1, p. 40-9, 2014.
0003-4800
10.1111/ahg.12047.
url https://www.arca.fiocruz.br/handle/icict/9431
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/9431/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/9431/3/2014_036.pdf.txt
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