Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages

Detalhes bibliográficos
Autor(a) principal: Soares, Neci Matos
Data de Publicação: 2010
Outros Autores: Leal, T. F, Fiúza, M. C, Reis, Eliana Almeida Gomes, Souza, M. A. L, dosSantos, Washington Luis Conrado, Pontes-de-Carvalho, Lain Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7649
Resumo: Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de An álises Clínicas e Toxicológicas. Salvador, BA, Brasil
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spelling Soares, Neci MatosLeal, T. FFiúza, M. CReis, Eliana Almeida GomesSouza, M. A. LdosSantos, Washington Luis ConradoPontes-de-Carvalho, Lain Carlos2014-05-23T17:13:09Z2014-05-23T17:13:09Z2010SOARES, N. M. et al. Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages. Parasite Immunology, v. 32, p.259-266, 2010.1365-3024https://www.arca.fiocruz.br/handle/icict/764910.1111/j.1365-3024.2009.01187.xengBlackwell Publishing LtdPlasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de An álises Clínicas e Toxicológicas. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de An álises Clínicas e Toxicológicas. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de An álises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilThis work aimed at investigating the lipid profile of zoonotic visceral leishmaniasis (VL) patients' sera and the effect of lipoproteins on the in vitro production of tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-10 and IL-12 by Leishmania infantum-infected and uninfected macrophages. Lipids were quantified in 26 VL patients' sera and 26 healthy controls from a VL endemic area. The patients' sera had higher triglyceride and very low density lipoprotein (VLDL) levels, and much lower apolipoprotein A1, total cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL) levels than the control sera. Lipoprotein fractions were obtained by ultracentrifugation of sera. The addition of LDL and HDL to Leishmania-infected and uninfected macrophages, in physiological concentrations, enhanced the production of IL-6 and IL-10, but not of IL-12. LDL stimulated the production of TNF-alpha only in infected macrophages, whereas HDL stimulated the production of lower amounts of TNF-alpha in both infected and uninfected macrophages. VLDL stimulated only the production of IL-10. It is proposed herein that LDL may influence the development of VL by promoting the production of TNF-alpha by infected macrophages. A decrease in plasma LDL in some VL patients (to 20 mg/mL or less); however, would tend to reduce the production of TNF-alpha and therefore to limit the development of immune-mediated pathology, not withstanding the fact that it would perhaps increase the permissiveness of macrophages to Leishmania growth.CytokinesLeishmaniaLipoproteinsLeishmaniose Visceral/imunologiaLeishmaniose Visceral/patologiaLipídeos/sangueLipoproteínas/sangueMacrófagos/imunologiaMacrófagos/parasitologiaAdultoAnimaisCriançaCitocinas/secreçãoPré-EscolarFemininoHumanosLactenteLipoproteínas/isolamento & purificaçãoMasculinoUltracentrifugaçãoAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares NM Plasma lipoptroteins....pdfSoares NM Plasma lipoptroteins....pdfapplication/pdf282819https://www.arca.fiocruz.br/bitstream/icict/7649/1/Soares%20NM%20Plasma%20lipoptroteins....pdfc55a535a7b39f3ef64872769a76e7f63MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7649/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSoares NM Plasma lipoptroteins....pdf.txtSoares NM Plasma lipoptroteins....pdf.txtExtracted texttext/plain38183https://www.arca.fiocruz.br/bitstream/icict/7649/5/Soares%20NM%20Plasma%20lipoptroteins....pdf.txt2d8c1054a80c86a400004ccccb8e3668MD55THUMBNAILSoares NM Plasma lipoptroteins....pdf.jpgSoares NM Plasma lipoptroteins....pdf.jpgGenerated Thumbnailimage/jpeg2321https://www.arca.fiocruz.br/bitstream/icict/7649/4/Soares%20NM%20Plasma%20lipoptroteins....pdf.jpgd63b3aa02a261227753dcc8ff440639eMD54icict/76492023-03-15 14:32:55.066oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
spellingShingle Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
Soares, Neci Matos
Cytokines
Leishmania
Lipoproteins
Leishmaniose Visceral/imunologia
Leishmaniose Visceral/patologia
Lipídeos/sangue
Lipoproteínas/sangue
Macrófagos/imunologia
Macrófagos/parasitologia
Adulto
Animais
Criança
Citocinas/secreção
Pré-Escolar
Feminino
Humanos
Lactente
Lipoproteínas/isolamento & purificação
Masculino
Ultracentrifugação
Adulto Jovem
title_short Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title_full Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title_fullStr Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title_full_unstemmed Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
title_sort Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
author Soares, Neci Matos
author_facet Soares, Neci Matos
Leal, T. F
Fiúza, M. C
Reis, Eliana Almeida Gomes
Souza, M. A. L
dosSantos, Washington Luis Conrado
Pontes-de-Carvalho, Lain Carlos
author_role author
author2 Leal, T. F
Fiúza, M. C
Reis, Eliana Almeida Gomes
Souza, M. A. L
dosSantos, Washington Luis Conrado
Pontes-de-Carvalho, Lain Carlos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Neci Matos
Leal, T. F
Fiúza, M. C
Reis, Eliana Almeida Gomes
Souza, M. A. L
dosSantos, Washington Luis Conrado
Pontes-de-Carvalho, Lain Carlos
dc.subject.en.pt_BR.fl_str_mv Cytokines
Leishmania
Lipoproteins
topic Cytokines
Leishmania
Lipoproteins
Leishmaniose Visceral/imunologia
Leishmaniose Visceral/patologia
Lipídeos/sangue
Lipoproteínas/sangue
Macrófagos/imunologia
Macrófagos/parasitologia
Adulto
Animais
Criança
Citocinas/secreção
Pré-Escolar
Feminino
Humanos
Lactente
Lipoproteínas/isolamento & purificação
Masculino
Ultracentrifugação
Adulto Jovem
dc.subject.decs.pt_BR.fl_str_mv Leishmaniose Visceral/imunologia
Leishmaniose Visceral/patologia
Lipídeos/sangue
Lipoproteínas/sangue
Macrófagos/imunologia
Macrófagos/parasitologia
Adulto
Animais
Criança
Citocinas/secreção
Pré-Escolar
Feminino
Humanos
Lactente
Lipoproteínas/isolamento & purificação
Masculino
Ultracentrifugação
Adulto Jovem
description Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de An álises Clínicas e Toxicológicas. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-05-23T17:13:09Z
dc.date.available.fl_str_mv 2014-05-23T17:13:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, N. M. et al. Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages. Parasite Immunology, v. 32, p.259-266, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7649
dc.identifier.issn.none.fl_str_mv 1365-3024
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-3024.2009.01187.x
identifier_str_mv SOARES, N. M. et al. Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages. Parasite Immunology, v. 32, p.259-266, 2010.
1365-3024
10.1111/j.1365-3024.2009.01187.x
url https://www.arca.fiocruz.br/handle/icict/7649
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing Ltd
publisher.none.fl_str_mv Blackwell Publishing Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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