Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40891 |
Resumo: | Acesso aberto em 20/04/2020 - https://www.jimmunol.org/content/jimmunol/179/12/8500.full.pdf |
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Pacheco, PatriciaAbreu, Adriana Vieira deGomes, Rachel N.LIma, Giselle BarbosaWermelinger, Leticia B.Monteiro, Clarissa M. MayaSilva, Adriana R.Bozza, Marcelo T.Faria Neto, Hugo Caire C.Melo, Christianne BandeiraBozza, Patrícia T.2020-04-20T17:26:35Z2020-04-20T17:26:35Z2009PACHECO, Patricia et al. Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. Journal of Immunology, p. 1-10, 2020.0741-5400https://www.arca.fiocruz.br/handle/icict/4089110.4049/jimmunol.179.12.85001550-6606Acesso aberto em 20/04/2020 - https://www.jimmunol.org/content/jimmunol/179/12/8500.full.pdfFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Lipid bodies (also known as lipid droplets) are emerging as inflammatory organelles with roles in the innate immune response to infections and inflammatory processes. In this study, we identified MCP-1 as a key endogenous mediator of lipid body biogenesis in infection-driven inflammatory disorders and we described the cellular mechanisms and signaling pathways involved in the ability of MCP-1 to regulate the biogenesis and leukotriene B4 (LTB4) synthetic function of lipid bodies. In vivo assays in MCP-1 / mice revealed that endogenous MCP-1 produced during polymicrobial infection or LPS-driven inflammatory responses has a critical role on the activation of lipid body-assembling machinery, as well as on empowering enzymatically these newly formed lipid bodies with LTB4 synthetic function within macrophages. MCP-1 triggered directly the rapid biogenesis of distinctive LTB4-synthesizing lipid bodies via CCR2-driven ERK- and PI3K-dependent intracellular signaling in in vitro-stimulated macrophages. Disturbance of microtubule organization by microtubule-active drugs demonstrated that MCP-1-induced lipid body biogenesis also signals through a pathway dependent on microtubular dynamics. Besides biogenic process, microtubules control LTB4-synthesizing function of MCP-1-elicited lipid bodies, in part by regulating the compartmentalization of key proteins, as adipose differentiation-related protein and 5-lipoxygenase. Therefore, infection-elicited MCP-1, besides its known CCR2-driven chemotactic function, appears as a key activator of lipid body biogenic and functional machineries, signaling through a microtubule-dependent manner.engWileyQuimiocina da proteína quimioatraente de monócitosBiogêneseCorpos lipídicosMacrófagosResposta imune inataMonocyte Chemoattractant ProteinChemokineBiogenesisLipid bodiesInnate Immune ResponseMacrophageLipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis |
| title |
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis |
| spellingShingle |
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis Pacheco, Patricia Quimiocina da proteína quimioatraente de monócitos Biogênese Corpos lipídicos Macrófagos Resposta imune inata Monocyte Chemoattractant Protein Chemokine Biogenesis Lipid bodies Innate Immune Response Macrophage |
| title_short |
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis |
| title_full |
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis |
| title_fullStr |
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis |
| title_full_unstemmed |
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis |
| title_sort |
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis |
| author |
Pacheco, Patricia |
| author_facet |
Pacheco, Patricia Abreu, Adriana Vieira de Gomes, Rachel N. LIma, Giselle Barbosa Wermelinger, Leticia B. Monteiro, Clarissa M. Maya Silva, Adriana R. Bozza, Marcelo T. Faria Neto, Hugo Caire C. Melo, Christianne Bandeira Bozza, Patrícia T. |
| author_role |
author |
| author2 |
Abreu, Adriana Vieira de Gomes, Rachel N. LIma, Giselle Barbosa Wermelinger, Leticia B. Monteiro, Clarissa M. Maya Silva, Adriana R. Bozza, Marcelo T. Faria Neto, Hugo Caire C. Melo, Christianne Bandeira Bozza, Patrícia T. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pacheco, Patricia Abreu, Adriana Vieira de Gomes, Rachel N. LIma, Giselle Barbosa Wermelinger, Leticia B. Monteiro, Clarissa M. Maya Silva, Adriana R. Bozza, Marcelo T. Faria Neto, Hugo Caire C. Melo, Christianne Bandeira Bozza, Patrícia T. |
| dc.subject.other.pt_BR.fl_str_mv |
Quimiocina da proteína quimioatraente de monócitos Biogênese Corpos lipídicos Macrófagos Resposta imune inata |
| topic |
Quimiocina da proteína quimioatraente de monócitos Biogênese Corpos lipídicos Macrófagos Resposta imune inata Monocyte Chemoattractant Protein Chemokine Biogenesis Lipid bodies Innate Immune Response Macrophage |
| dc.subject.en.pt_BR.fl_str_mv |
Monocyte Chemoattractant Protein Chemokine Biogenesis Lipid bodies Innate Immune Response Macrophage |
| description |
Acesso aberto em 20/04/2020 - https://www.jimmunol.org/content/jimmunol/179/12/8500.full.pdf |
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2009 |
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2009 |
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2020-04-20T17:26:35Z |
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2020-04-20T17:26:35Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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PACHECO, Patricia et al. Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. Journal of Immunology, p. 1-10, 2020. |
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https://www.arca.fiocruz.br/handle/icict/40891 |
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0741-5400 |
| dc.identifier.doi.none.fl_str_mv |
10.4049/jimmunol.179.12.8500 |
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1550-6606 |
| identifier_str_mv |
PACHECO, Patricia et al. Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. Journal of Immunology, p. 1-10, 2020. 0741-5400 10.4049/jimmunol.179.12.8500 1550-6606 |
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Wiley |
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Wiley |
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