Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis

Detalhes bibliográficos
Autor(a) principal: Mattos, Katherine A.
Data de Publicação: 2010
Outros Autores: D'Avila, Heloisa, Rodrigues, Luciana S., Oliveira, Viviane G. C., Sarno, Euzenir N., Atella, Georgia C., Pereira, Geraldo M., Bozza, Patrícia T., Pessolani, Maria Cristina V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40890
Resumo: Acesso aberto em 20/04/2020 - https://jlb.onlinelibrary.wiley.com/doi/full/10.1189/jlb.0609433
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spelling Mattos, Katherine A.D'Avila, HeloisaRodrigues, Luciana S.Oliveira, Viviane G. C.Sarno, Euzenir N.Atella, Georgia C.Pereira, Geraldo M.Bozza, Patrícia T.Pessolani, Maria Cristina V.2020-04-20T16:41:25Z2020-04-20T16:41:25Z2010MATTOS, Katherine A. et al. Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. Journal of Leukocyte Biology, v. 87, p. 371-384, 2010.0741-5400https://www.arca.fiocruz.br/handle/icict/4089010.1189/jlb.06094331938-3673Acesso aberto em 20/04/2020 - https://jlb.onlinelibrary.wiley.com/doi/full/10.1189/jlb.0609433Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Micobiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Micobiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Micobiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Laboratório de Bioquímica de Lipídeos e Lipoproteínas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Micobiologia Celular. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Micobiologia Celular. Rio de Janeiro, RJ, Brasil.A hallmark of LL is the accumulation of Virchow's foamy macrophages. However, the origin and nature of these lipids, as well as their function and contribution to leprosy disease, remain unclear. We herein show that macrophages present in LL dermal lesions are highly positive for ADRP, suggesting that their foamy aspect is at least in part derived from LD (also known as lipid bodies) accumulation induced during ML infection. Indeed, the capacity of ML to induce LD formation was confirmed in vivo via an experimental model of mouse pleurisy and in in vitro studies with human peripheral monocytes and murine peritoneal macrophages. Furthermore, infected cells were shown to propagate LD induction to uninfected, neighboring cells by generating a paracrine signal, for which TLR2 and TLR6 were demonstrated to be essential. However, TLR2 and TLR6 deletions affected LD formation in bacterium-bearing cells only partially, suggesting the involvement of alternative receptors of the innate immune response besides TLR2/6 for ML recognition by macrophages. Finally, a direct correlation between LD formation and PGE(2) production was observed, indicating that ML-induced LDs constitute intracellular sites for eicosanoid synthesis and that foamy cells may be critical regulators in subverting the immune response in leprosy.engWileyHanseníaseGotículas lipídicasFormação de EicosanóidesMycobacterium lepraePatogêneseLipid dropletLeprosyEicosanoid formationMycobacterium lepraePathogenesisLipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
title Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
spellingShingle Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
Mattos, Katherine A.
Hanseníase
Gotículas lipídicas
Formação de Eicosanóides
Mycobacterium leprae
Patogênese
Lipid droplet
Leprosy
Eicosanoid formation
Mycobacterium leprae
Pathogenesis
title_short Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
title_full Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
title_fullStr Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
title_full_unstemmed Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
title_sort Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
author Mattos, Katherine A.
author_facet Mattos, Katherine A.
D'Avila, Heloisa
Rodrigues, Luciana S.
Oliveira, Viviane G. C.
Sarno, Euzenir N.
Atella, Georgia C.
Pereira, Geraldo M.
Bozza, Patrícia T.
Pessolani, Maria Cristina V.
author_role author
author2 D'Avila, Heloisa
Rodrigues, Luciana S.
Oliveira, Viviane G. C.
Sarno, Euzenir N.
Atella, Georgia C.
Pereira, Geraldo M.
Bozza, Patrícia T.
Pessolani, Maria Cristina V.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mattos, Katherine A.
D'Avila, Heloisa
Rodrigues, Luciana S.
Oliveira, Viviane G. C.
Sarno, Euzenir N.
Atella, Georgia C.
Pereira, Geraldo M.
Bozza, Patrícia T.
Pessolani, Maria Cristina V.
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Gotículas lipídicas
Formação de Eicosanóides
Mycobacterium leprae
Patogênese
topic Hanseníase
Gotículas lipídicas
Formação de Eicosanóides
Mycobacterium leprae
Patogênese
Lipid droplet
Leprosy
Eicosanoid formation
Mycobacterium leprae
Pathogenesis
dc.subject.en.pt_BR.fl_str_mv Lipid droplet
Leprosy
Eicosanoid formation
Mycobacterium leprae
Pathogenesis
description Acesso aberto em 20/04/2020 - https://jlb.onlinelibrary.wiley.com/doi/full/10.1189/jlb.0609433
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2020-04-20T16:41:25Z
dc.date.available.fl_str_mv 2020-04-20T16:41:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MATTOS, Katherine A. et al. Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. Journal of Leukocyte Biology, v. 87, p. 371-384, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40890
dc.identifier.issn.pt_BR.fl_str_mv 0741-5400
dc.identifier.doi.none.fl_str_mv 10.1189/jlb.0609433
dc.identifier.eissn.none.fl_str_mv 1938-3673
identifier_str_mv MATTOS, Katherine A. et al. Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. Journal of Leukocyte Biology, v. 87, p. 371-384, 2010.
0741-5400
10.1189/jlb.0609433
1938-3673
url https://www.arca.fiocruz.br/handle/icict/40890
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/40890/2/MariaCPessolani_PatriciaBozza_etal_IOC_2010.pdf
https://www.arca.fiocruz.br/bitstream/icict/40890/3/MariaCPessolani_PatriciaBozza_etal_IOC_2010.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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