Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

Detalhes bibliográficos
Autor(a) principal: Coutinho, Diego de Sá
Data de Publicação: 2018
Outros Autores: Pacheco, Maria Talita, Frozza, Rudimar Luiz, Bernardi, Andressa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28463
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.
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spelling Coutinho, Diego de SáPacheco, Maria TalitaFrozza, Rudimar LuizBernardi, Andressa2018-08-30T12:34:44Z2018-08-30T12:34:44Z2018COUTINHO, Diego de Sá; et al. Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. International Journal of Molecular Sciences, v.19, n.1812, 25p, 2018.1661-6596https://www.arca.fiocruz.br/handle/icict/2846310.3390/ijms190618121422-0067engMDPIDoenças crônicasInflamacãoInflammationresveratrolchronic diseasesAnti-Inflammatory Effects of Resveratrol: Mechanistic Insightsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. We highlight how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and we identify future opportunities for the evaluation of its clinical feasibility.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28463/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdiego_coutinho_etal_IOC_2018.pdfdiego_coutinho_etal_IOC_2018.pdfapplication/pdf737222https://www.arca.fiocruz.br/bitstream/icict/28463/2/diego_coutinho_etal_IOC_2018.pdf1247c86fda8875d81b6be3283b1b1780MD52TEXTdiego_coutinho_etal_IOC_2018.pdf.txtdiego_coutinho_etal_IOC_2018.pdf.txtExtracted texttext/plain106768https://www.arca.fiocruz.br/bitstream/icict/28463/3/diego_coutinho_etal_IOC_2018.pdf.txtff35164ab13e359420c09717d9c3c9c0MD53icict/284632018-08-31 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dc.title.pt_BR.fl_str_mv Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
title Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
spellingShingle Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
Coutinho, Diego de Sá
Doenças crônicas
Inflamacão
Inflammation
resveratrol
chronic diseases
title_short Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
title_full Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
title_fullStr Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
title_full_unstemmed Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
title_sort Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
author Coutinho, Diego de Sá
author_facet Coutinho, Diego de Sá
Pacheco, Maria Talita
Frozza, Rudimar Luiz
Bernardi, Andressa
author_role author
author2 Pacheco, Maria Talita
Frozza, Rudimar Luiz
Bernardi, Andressa
author2_role author
author
author
dc.contributor.author.fl_str_mv Coutinho, Diego de Sá
Pacheco, Maria Talita
Frozza, Rudimar Luiz
Bernardi, Andressa
dc.subject.other.pt_BR.fl_str_mv Doenças crônicas
Inflamacão
topic Doenças crônicas
Inflamacão
Inflammation
resveratrol
chronic diseases
dc.subject.en.pt_BR.fl_str_mv Inflammation
resveratrol
chronic diseases
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-30T12:34:44Z
dc.date.available.fl_str_mv 2018-08-30T12:34:44Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COUTINHO, Diego de Sá; et al. Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. International Journal of Molecular Sciences, v.19, n.1812, 25p, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28463
dc.identifier.issn.pt_BR.fl_str_mv 1661-6596
dc.identifier.doi.none.fl_str_mv 10.3390/ijms19061812
dc.identifier.eissn.none.fl_str_mv 1422-0067
identifier_str_mv COUTINHO, Diego de Sá; et al. Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. International Journal of Molecular Sciences, v.19, n.1812, 25p, 2018.
1661-6596
10.3390/ijms19061812
1422-0067
url https://www.arca.fiocruz.br/handle/icict/28463
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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