Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45550 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. |
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Mojoli, AndrésGonçalves, Barbara SimonsonTemerozo, Jairo R.Alves, Bruno CisterGeddes, VictorHerlinger, AliceAguiar, Renato SantanaPilotto, José HenriqueSaraiva, Elvira M.Bou‑Habib, Dumith Chequer Bou2021-01-10T18:06:12Z2021-01-10T18:06:12Z2020MOJOLI, Andrés et al. Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages. Scientifc Reports, v. 10, p. 1-15, 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/4555010.1038/s41598-020-75357-22045-2322engNature ResearchNeutrófilos extracelularesArmadilhasDoadores saudáveisindivíduos infectadosMacrófagosProdução de HIV-1Neutrophil extracellularTrapsHealthy donorsHIV‑1‑infected individualsrestrict HIV‑1 productionMacrophagesNeutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microniologia Prof. Paulo de Góes, Departamento de Imunologia. Laboratório de Imunobiologia da Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Neutrophils release extracellular traps (NETs) after interaction with microorganisms and physiological or synthetic products. NETs consist of decondensed chromatin complexed with proteins, some of them with microbicidal properties. Because NETs can modulate the functioning of HIV-1 target cells, we aimed to verify whether they modify HIV-1 replication in macrophages. We found that exposure of HIV-1-infected macrophages to NETs resulted in significant inhibition of viral replication. The NET anti-HIV-1 action was independent of other soluble factors released by the activated neutrophils, but otherwise dependent on the molecular integrity of NETs, since NET-treatment with protease or DNase abolished this effect. NETs induced macrophage production of the anti-HIV-1 β-chemokines Rantes and MIP-1β, and reduced the levels of integrated HIV-1 DNA in the macrophage genome, which may explain the decreased virus production by infected macrophages. Moreover, the residual virions released by NET-treated HIV-1-infected macrophages lost infectivity. In addition, elevated levels of DNA-elastase complexes were detected in the plasma from HIV-1-infected individuals, and neutrophils from these patients released NETs, which also inhibited HIV-1 replication in in vitro infected macrophages. Our results reveal that NETs may function as an innate immunity mechanism able to restrain HIV-1 production in macrophages.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45550/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAndresMojoli_JoseHPilotto_etal_IOC_2020.pdfAndresMojoli_JoseHPilotto_etal_IOC_2020.pdfapplication/pdf6481602https://www.arca.fiocruz.br/bitstream/icict/45550/2/AndresMojoli_JoseHPilotto_etal_IOC_2020.pdfc61b8c726677628791add6c1e53f8d4bMD52TEXTAndresMojoli_JoseHPilotto_etal_IOC_2020.pdf.txtAndresMojoli_JoseHPilotto_etal_IOC_2020.pdf.txtExtracted texttext/plain64445https://www.arca.fiocruz.br/bitstream/icict/45550/3/AndresMojoli_JoseHPilotto_etal_IOC_2020.pdf.txt341fcb7e32333a8bb15750e0a7fa6c95MD53icict/455502021-03-13 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dc.title.pt_BR.fl_str_mv |
Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages |
title |
Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages |
spellingShingle |
Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages Mojoli, Andrés Neutrófilos extracelulares Armadilhas Doadores saudáveis indivíduos infectados Macrófagos Produção de HIV-1 Neutrophil extracellular Traps Healthy donors HIV‑1‑infected individuals restrict HIV‑1 production Macrophages |
title_short |
Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages |
title_full |
Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages |
title_fullStr |
Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages |
title_full_unstemmed |
Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages |
title_sort |
Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages |
author |
Mojoli, Andrés |
author_facet |
Mojoli, Andrés Gonçalves, Barbara Simonson Temerozo, Jairo R. Alves, Bruno Cister Geddes, Victor Herlinger, Alice Aguiar, Renato Santana Pilotto, José Henrique Saraiva, Elvira M. Bou‑Habib, Dumith Chequer Bou |
author_role |
author |
author2 |
Gonçalves, Barbara Simonson Temerozo, Jairo R. Alves, Bruno Cister Geddes, Victor Herlinger, Alice Aguiar, Renato Santana Pilotto, José Henrique Saraiva, Elvira M. Bou‑Habib, Dumith Chequer Bou |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mojoli, Andrés Gonçalves, Barbara Simonson Temerozo, Jairo R. Alves, Bruno Cister Geddes, Victor Herlinger, Alice Aguiar, Renato Santana Pilotto, José Henrique Saraiva, Elvira M. Bou‑Habib, Dumith Chequer Bou |
dc.subject.other.pt_BR.fl_str_mv |
Neutrófilos extracelulares Armadilhas Doadores saudáveis indivíduos infectados Macrófagos Produção de HIV-1 |
topic |
Neutrófilos extracelulares Armadilhas Doadores saudáveis indivíduos infectados Macrófagos Produção de HIV-1 Neutrophil extracellular Traps Healthy donors HIV‑1‑infected individuals restrict HIV‑1 production Macrophages |
dc.subject.en.pt_BR.fl_str_mv |
Neutrophil extracellular Traps Healthy donors HIV‑1‑infected individuals restrict HIV‑1 production Macrophages |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-01-10T18:06:12Z |
dc.date.available.fl_str_mv |
2021-01-10T18:06:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MOJOLI, Andrés et al. Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages. Scientifc Reports, v. 10, p. 1-15, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45550 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-020-75357-2 |
dc.identifier.eissn.none.fl_str_mv |
2045-2322 |
identifier_str_mv |
MOJOLI, Andrés et al. Neutrophil extracellular traps from healthy donors and HIV‑1‑infected individuals restrict HIV‑1 production in macrophages. Scientifc Reports, v. 10, p. 1-15, 2020. 2045-2322 10.1038/s41598-020-75357-2 |
url |
https://www.arca.fiocruz.br/handle/icict/45550 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Nature Research |
publisher.none.fl_str_mv |
Nature Research |
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