A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae

Detalhes bibliográficos
Autor(a) principal: Ramirez, Jose Luis
Data de Publicação: 2015
Outros Autores: Oliveira, Giselle de Almeida, Calvo, Eric, Dalli, Jesmond, Colas, Romain A., Serhan, Charles N., Ribeiro, Jose M., Barillas-Mury, Carolina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51023
Resumo: NATIONAL INSTITUTES OF HEALTH
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spelling Ramirez, Jose LuisOliveira, Giselle de AlmeidaCalvo, EricDalli, JesmondColas, Romain A.Serhan, Charles N.Ribeiro, Jose M.Barillas-Mury, Carolina2022-02-04T16:23:24Z2022-02-04T16:23:24Z2015RAMIREZ, Jose Luis et al. A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. Nat Commun, n. 6, 7403, 2015. doi.org/10.1038/ncomms84032041-1723https://www.arca.fiocruz.br/handle/icict/5102310.1038/ncomms8403NATIONAL INSTITUTES OF HEALTHLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, 20852, Maryland, USAFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brazil/Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USALaboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USADepartment of Anesthesiology. Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine. Brigham and Women’s Hospital and Harvard Medical School. Boston, Massachusetts, USADepartment of Anesthesiology. Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine. Brigham and Women’s Hospital and Harvard Medical School. Boston, Massachusetts, USADepartment of Anesthesiology. Center for Experimental Therapeutics and Reperfusion Injury, Perioperative, and Pain Medicine. Brigham and Women’s Hospital and Harvard Medical School. Boston, Massachusetts, USALaboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USALaboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA"Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to ‘remember’ a previous encounter with a pathogen has not been established. Challenged mosquitoes constitutively release a soluble haemocyte differentiation factor into their haemolymph that, when transferred into Naive mosquitoes, also induces priming. Here we show that this factor consists of a Lipoxin/ Lipocalin complex. We demonstrate that innate immune priming in mosquitoes involves a persistent increase in expression of Evokin (a lipid carrier of the lipocalin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A4. Plasmodium ookinete midgut invasion triggers immune priming by inducing the release of a mosquito lipoxin/ lipocalin complex."engNatureA mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiaeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/51023/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALA mosquito lipoxin.pdfA mosquito lipoxin.pdfapplication/pdf4446174https://www.arca.fiocruz.br/bitstream/icict/51023/2/A%20mosquito%20lipoxin.pdf4b80148d88575c3abd850fab014659a6MD52icict/510232022-02-04 13:23:24.445oai:www.arca.fiocruz.br:icict/51023Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-02-04T16:23:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
title A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
spellingShingle A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
Ramirez, Jose Luis
title_short A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
title_full A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
title_fullStr A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
title_full_unstemmed A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
title_sort A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
author Ramirez, Jose Luis
author_facet Ramirez, Jose Luis
Oliveira, Giselle de Almeida
Calvo, Eric
Dalli, Jesmond
Colas, Romain A.
Serhan, Charles N.
Ribeiro, Jose M.
Barillas-Mury, Carolina
author_role author
author2 Oliveira, Giselle de Almeida
Calvo, Eric
Dalli, Jesmond
Colas, Romain A.
Serhan, Charles N.
Ribeiro, Jose M.
Barillas-Mury, Carolina
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ramirez, Jose Luis
Oliveira, Giselle de Almeida
Calvo, Eric
Dalli, Jesmond
Colas, Romain A.
Serhan, Charles N.
Ribeiro, Jose M.
Barillas-Mury, Carolina
description NATIONAL INSTITUTES OF HEALTH
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2022-02-04T16:23:24Z
dc.date.available.fl_str_mv 2022-02-04T16:23:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RAMIREZ, Jose Luis et al. A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. Nat Commun, n. 6, 7403, 2015. doi.org/10.1038/ncomms8403
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51023
dc.identifier.issn.pt_BR.fl_str_mv 2041-1723
dc.identifier.doi.none.fl_str_mv 10.1038/ncomms8403
identifier_str_mv RAMIREZ, Jose Luis et al. A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. Nat Commun, n. 6, 7403, 2015. doi.org/10.1038/ncomms8403
2041-1723
10.1038/ncomms8403
url https://www.arca.fiocruz.br/handle/icict/51023
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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