The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.

Assis, Diana Cavalcante Miranda de; Lima, Êmyle Martins; Goes, Bruno Teixeira; Cavalcanti, João Zugaib; Paixão, Alaí Barbosa; Santos, Marcos André Vannier dos; Martinez, Ana Maria Blanco; Baptista, Abrahão Fontes

The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.

Detalhes bibliográficos
Autor(a) principal:	Assis, Diana Cavalcante Miranda de
Data de Publicação:	2014
Outros Autores:	Lima, Êmyle Martins, Goes, Bruno Teixeira, Cavalcanti, João Zugaib, Paixão, Alaí Barbosa, Santos, Marcos André Vannier dos, Martinez, Ana Maria Blanco, Baptista, Abrahão Fontes
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/8367
Resumo:	Federal University of Bahia. Faculty of Medicine. Salvador, BA, Brazil / Federal University of Bahia. Functional Electrostimulation Laboratory. Department of Biomorphology. Salvador, BA, Brazil

Metadados do item

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spelling	Assis, Diana Cavalcante Miranda deLima, Êmyle MartinsGoes, Bruno TeixeiraCavalcanti, João ZugaibPaixão, Alaí BarbosaSantos, Marcos André Vannier dosMartinez, Ana Maria BlancoBaptista, Abrahão Fontes2014-09-12T17:04:04Z2014-09-12T17:04:04Z2014ASSIS, D. C. M. et al. The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice. Biomedical Research International, p. 572949, 2014.2314-6141https://www.arca.fiocruz.br/handle/icict/836710.1155/2014/572949engHindawi Publishing CorporationThe parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. Faculty of Medicine. Salvador, BA, Brazil / Federal University of Bahia. Functional Electrostimulation Laboratory. Department of Biomorphology. Salvador, BA, BrazilFederal University of Bahia. Faculty of Medicine. Salvador, BA, Brazil / Federal University of Bahia. Functional Electrostimulation Laboratory. Department of Biomorphology. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahian School of Medicine and Human Health. Biotechnology and Bioprospection Nucleus. Salvador, BA, BrazilUniversity of São Paulo. Faculty of Medicine of Ribeirão Preto. Physiology and Synaptic Plasticity Laboratory. Department of Physiology. São Paulo, SP, BrazilFederal University of Bahia. Functional Electrostimulation Laboratory. Department of Biomorphology. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Biofísica Carlos Chagas Filho. Cidade Universitária. Rio de Janeiro, RJ, BrasilFederal University of Rio de Janeiro. Neuroregeneration and Repair Laboratory. Cidade Universitária. Rio de Janeiro, RJ, BrazilWe investigated the effect of two frequencies of transcutaneous electrical nerve stimulation (TENS) applied immediately after lesion on peripheral nerve regeneration after a mouse sciatic crush injury. The animals were anesthetized and subjected to crushing of the right sciatic nerve and then separated into three groups: nontreated, Low-TENS (4 Hz), and High-TENS (100 Hz). The animals of Low- and High-TENS groups were stimulated for 2 h immediately after the surgical procedure, while the nontreated group was only positioned for the same period. After five weeks the animals were euthanized, and the nerves dissected bilaterally for histological and histomorphometric analysis. Histological assessment by light and electron microscopy showed that High-TENS and nontreated nerves had a similar profile, with extensive signs of degeneration. Conversely, Low-TENS led to increased regeneration, displaying histological aspects similar to control nerves. High-TENS also led to decreased density of fibers in the range of 6-12 µm diameter and decreased fiber diameter and myelin area in the range of 0-2 µm diameter. These findings suggest that High-TENS applied just after a peripheral nerve crush may be deleterious for regeneration, whereas Low-TENS may increase nerve regeneration capacity.TENSEstimulação elétrica nervosa transcutâneaNervo ciáticoMicroscopia eletrônicaDoenças dos nervos periféricosNervos periféricosRegeneração nervosainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8367/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALAssis DCM The parameters....pdfAssis DCM The parameters....pdfapplication/pdf2318578https://www.arca.fiocruz.br/bitstream/icict/8367/2/Assis%20DCM%20The%20parameters....pdf2079799280a32cbf89e0868ce7a349ebMD52TEXTAssis DCM The parameters....pdf.txtAssis DCM The parameters....pdf.txtExtracted texttext/plain34891https://www.arca.fiocruz.br/bitstream/icict/8367/3/Assis%20DCM%20The%20parameters....pdf.txta405ce5363032de8fbab267bbdb5fa51MD53icict/83672023-03-15 14:33:03.479oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.
title	The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.
spellingShingle	The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice. Assis, Diana Cavalcante Miranda de TENS Estimulação elétrica nervosa transcutânea Nervo ciático Microscopia eletrônica Doenças dos nervos periféricos Nervos periféricos Regeneração nervosa
title_short	The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.
title_full	The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.
title_fullStr	The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.
title_full_unstemmed	The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.
title_sort	The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.
author	Assis, Diana Cavalcante Miranda de
author_facet	Assis, Diana Cavalcante Miranda de Lima, Êmyle Martins Goes, Bruno Teixeira Cavalcanti, João Zugaib Paixão, Alaí Barbosa Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco Baptista, Abrahão Fontes
author_role	author
author2	Lima, Êmyle Martins Goes, Bruno Teixeira Cavalcanti, João Zugaib Paixão, Alaí Barbosa Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco Baptista, Abrahão Fontes
author2_role	author author author author author author author
dc.contributor.author.fl_str_mv	Assis, Diana Cavalcante Miranda de Lima, Êmyle Martins Goes, Bruno Teixeira Cavalcanti, João Zugaib Paixão, Alaí Barbosa Santos, Marcos André Vannier dos Martinez, Ana Maria Blanco Baptista, Abrahão Fontes
dc.subject.decs.pt_BR.fl_str_mv	TENS Estimulação elétrica nervosa transcutânea Nervo ciático Microscopia eletrônica Doenças dos nervos periféricos Nervos periféricos Regeneração nervosa
topic	TENS Estimulação elétrica nervosa transcutânea Nervo ciático Microscopia eletrônica Doenças dos nervos periféricos Nervos periféricos Regeneração nervosa
description	Federal University of Bahia. Faculty of Medicine. Salvador, BA, Brazil / Federal University of Bahia. Functional Electrostimulation Laboratory. Department of Biomorphology. Salvador, BA, Brazil
publishDate	2014
dc.date.accessioned.fl_str_mv	2014-09-12T17:04:04Z
dc.date.available.fl_str_mv	2014-09-12T17:04:04Z
dc.date.issued.fl_str_mv	2014
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ASSIS, D. C. M. et al. The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice. Biomedical Research International, p. 572949, 2014.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/8367
dc.identifier.issn.none.fl_str_mv	2314-6141
dc.identifier.doi.none.fl_str_mv	10.1155/2014/572949
identifier_str_mv	ASSIS, D. C. M. et al. The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice. Biomedical Research International, p. 572949, 2014. 2314-6141 10.1155/2014/572949
url	https://www.arca.fiocruz.br/handle/icict/8367
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Hindawi Publishing Corporation
publisher.none.fl_str_mv	Hindawi Publishing Corporation
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
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The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.

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