Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40276 |
Resumo: | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. |
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Jesus, Jaqueline Goes deWallau, Gabriel da LuzMaia, Maricelia LimaXavier, JoilsonLima, Maria Aparecida OliveiraFonseca, VagnerAbreu, Alvaro Salgado deTosta, Stephane Fraga de OliveiraAmaral, Helineide Ramos doLima, Italo Andrade BarbosaSilva, Paloma VianaSantos, Daiana Carlos dosOliveira, Aline Sousa deSouza, Siane Campos deFalcão, Melissa BarretoCerqueira, ErenildeMachado, Laís CeschiniSobral, Mariana CarolinaRezende, Tatiana Maria TeodoroPereira, Mylena RibeiroPereira, Felicidade MotaMaia, Zuinara Pereira GusmãoFrança, Rafael Freitas de OliveiraAbreu, Andre Luiz deMelo, Carlos Frederico Campelo de Albuquerque eFaria, Nuno RodriguesCunha, Rivaldo Venâncio daGiovanetti, MartaAlcantara, Luiz Carlos Junior2020-03-10T15:52:06Z2020-03-10T15:52:06Z2020JESUS, Jaqueline Goes de et al. Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil. Plos One, v. 15, n. 1, p. 1-11, Jan. 2020.1932-6203https://www.arca.fiocruz.br/handle/icict/4027610.1371/journal.pone.0226098engPublic Libray of ScienceGenótipo chikungunya ECSChikungunyaSurtoClasse média altaRegião NordesteBrasilChikungunya ECSA genotypeChikungunyaLocal outbreakNortheast BrazilUpper medium classPersistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil / Ministério da Saúde. Secretaria de Saúde de Feira de Santana. Feira de Santana, BA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / University of KwaZulu-Natal. College of Health Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Ministério da Saúde. Secretaria de Saúde de Feira de Santana. Feira de Santana, BA, Brasil.Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.Laboratório Central de Saúde Pública da Bahia. Salvador, BA, Brasil.Laboratório Central de Saúde Pública da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Coordenação Geral de Laboratórios de Saúde Pública. Brasília, DF, Brasil.Organizac¸ão Pan-Americana da Saúde / Organização Mundial da Saúde. Brasília, DF, Brasil.University of Oxford. Department of Zoology. Oxford, United Kingdom.Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina. Departamento de Clínica Médica. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.The chikungunya East/Central/South/Africa virus lineage (CHIKV-ECSA) was first detected in Brazil in the municipality of Feira de Santana (FS) by mid 2014. Following that, a large number of CHIKV cases have been notified in FS, which is the second-most populous city in Bahia state, northeastern Brazil, and plays an important role on the spread to other Brazilian states due to climate conditions and the abundance of competent vectors. To better understand CHIKV dynamics in Bahia state, we generated 5 complete genome sequences from a local outbreak raised in Serraria Brasil, a neighbourhood in FS, by next-generation sequencing using Illumina approach. Phylogenetic reconstructions revealed that the new FS genomes belongs to the ECSA genotype and falls within a single strongly supported monophyletic clade that includes other older CHIKV sequences from the same location, suggesting the persistence of the virus during distinct epidemic seasons. We also performed minor variants analysis and found a small number of SNPs per sample (b_29L and e_45SR = 16 SNPs, c_29SR = 29 and d_45PL and f_45FL = 21 SNPs). Out of the 93 SNPs found, 71 are synonymous, 21 are non-synonymous and one generated a stop codon. Although those mutations are not related to the increase of virus replication and/or infectivity, some SNPs were found in non-structural proteins which may have an effect on viral evasion from the mammal immunological system. These findings reinforce the needing of further studies on those variants and of continued genomic surveillance strategies to track viral adaptations and to monitor CHIKV epidemics for improved public health control.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40276/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLuizCAJunior_VenancioCunha_etal_IOC_2020.pdfLuizCAJunior_VenancioCunha_etal_IOC_2020.pdfapplication/pdf1490527https://www.arca.fiocruz.br/bitstream/icict/40276/2/LuizCAJunior_VenancioCunha_etal_IOC_2020.pdf944fdb599d4da222ca2a492d91e3a396MD52TEXTLuizCAJunior_VenancioCunha_etal_IOC_2020.pdf.txtLuizCAJunior_VenancioCunha_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil |
| title |
Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil |
| spellingShingle |
Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil Jesus, Jaqueline Goes de Genótipo chikungunya ECS Chikungunya Surto Classe média alta Região Nordeste Brasil Chikungunya ECSA genotype Chikungunya Local outbreak Northeast Brazil Upper medium class |
| title_short |
Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil |
| title_full |
Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil |
| title_fullStr |
Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil |
| title_full_unstemmed |
Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil |
| title_sort |
Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil |
| author |
Jesus, Jaqueline Goes de |
| author_facet |
Jesus, Jaqueline Goes de Wallau, Gabriel da Luz Maia, Maricelia Lima Xavier, Joilson Lima, Maria Aparecida Oliveira Fonseca, Vagner Abreu, Alvaro Salgado de Tosta, Stephane Fraga de Oliveira Amaral, Helineide Ramos do Lima, Italo Andrade Barbosa Silva, Paloma Viana Santos, Daiana Carlos dos Oliveira, Aline Sousa de Souza, Siane Campos de Falcão, Melissa Barreto Cerqueira, Erenilde Machado, Laís Ceschini Sobral, Mariana Carolina Rezende, Tatiana Maria Teodoro Pereira, Mylena Ribeiro Pereira, Felicidade Mota Maia, Zuinara Pereira Gusmão França, Rafael Freitas de Oliveira Abreu, Andre Luiz de Melo, Carlos Frederico Campelo de Albuquerque e Faria, Nuno Rodrigues Cunha, Rivaldo Venâncio da Giovanetti, Marta Alcantara, Luiz Carlos Junior |
| author_role |
author |
| author2 |
Wallau, Gabriel da Luz Maia, Maricelia Lima Xavier, Joilson Lima, Maria Aparecida Oliveira Fonseca, Vagner Abreu, Alvaro Salgado de Tosta, Stephane Fraga de Oliveira Amaral, Helineide Ramos do Lima, Italo Andrade Barbosa Silva, Paloma Viana Santos, Daiana Carlos dos Oliveira, Aline Sousa de Souza, Siane Campos de Falcão, Melissa Barreto Cerqueira, Erenilde Machado, Laís Ceschini Sobral, Mariana Carolina Rezende, Tatiana Maria Teodoro Pereira, Mylena Ribeiro Pereira, Felicidade Mota Maia, Zuinara Pereira Gusmão França, Rafael Freitas de Oliveira Abreu, Andre Luiz de Melo, Carlos Frederico Campelo de Albuquerque e Faria, Nuno Rodrigues Cunha, Rivaldo Venâncio da Giovanetti, Marta Alcantara, Luiz Carlos Junior |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Jesus, Jaqueline Goes de Wallau, Gabriel da Luz Maia, Maricelia Lima Xavier, Joilson Lima, Maria Aparecida Oliveira Fonseca, Vagner Abreu, Alvaro Salgado de Tosta, Stephane Fraga de Oliveira Amaral, Helineide Ramos do Lima, Italo Andrade Barbosa Silva, Paloma Viana Santos, Daiana Carlos dos Oliveira, Aline Sousa de Souza, Siane Campos de Falcão, Melissa Barreto Cerqueira, Erenilde Machado, Laís Ceschini Sobral, Mariana Carolina Rezende, Tatiana Maria Teodoro Pereira, Mylena Ribeiro Pereira, Felicidade Mota Maia, Zuinara Pereira Gusmão França, Rafael Freitas de Oliveira Abreu, Andre Luiz de Melo, Carlos Frederico Campelo de Albuquerque e Faria, Nuno Rodrigues Cunha, Rivaldo Venâncio da Giovanetti, Marta Alcantara, Luiz Carlos Junior |
| dc.subject.other.pt_BR.fl_str_mv |
Genótipo chikungunya ECS Chikungunya Surto Classe média alta Região Nordeste Brasil |
| topic |
Genótipo chikungunya ECS Chikungunya Surto Classe média alta Região Nordeste Brasil Chikungunya ECSA genotype Chikungunya Local outbreak Northeast Brazil Upper medium class |
| dc.subject.en.pt_BR.fl_str_mv |
Chikungunya ECSA genotype Chikungunya Local outbreak Northeast Brazil Upper medium class |
| description |
Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. |
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2020 |
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2020-03-10T15:52:06Z |
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2020-03-10T15:52:06Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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JESUS, Jaqueline Goes de et al. Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil. Plos One, v. 15, n. 1, p. 1-11, Jan. 2020. |
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https://www.arca.fiocruz.br/handle/icict/40276 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0226098 |
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JESUS, Jaqueline Goes de et al. Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil. Plos One, v. 15, n. 1, p. 1-11, Jan. 2020. 1932-6203 10.1371/journal.pone.0226098 |
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