Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.

Detalhes bibliográficos
Autor(a) principal: Reis, Eliana Almeida Gomes
Data de Publicação: 2008
Outros Autores: Athanazio, Daniel Abensur, McBride, Alan John Alexander, Carmo, Theomira Mauadie de Azevedo, Santos, Isis Fernandes Magalhães, Harn Junior, Donald A, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7527
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Reis, Eliana Almeida GomesAthanazio, Daniel AbensurMcBride, Alan John AlexanderCarmo, Theomira Mauadie de AzevedoSantos, Isis Fernandes MagalhãesHarn Junior, Donald AReis, Mitermayer Galvão dos2014-04-22T18:27:59Z2014-04-22T18:27:59Z2008REIS, E. A. G. et al. Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection. Acta Tropica, v. 108, n. 2-3, p. 131-134, 2008.1873-6254https://www.arca.fiocruz.br/handle/icict/7527engElsevierInfluence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHarvard School of Public Health. Department of Immunology and Infectious Diseases. Boston, MA, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, BrasilWe previously reported the association of the major histocompatibility complex class II HLA-DQB1*0201 allele with hepatosplenic schistosomiasis. The aim of this studywas to evaluate the cytokine responses of peripheral blood mononuclear cells (PBMCs) and the serum levels of immunoglobulin isotypes. The study population was selected from a schistosomiasis endemic area. No significant differences in cytokine profileswere detected in PBMCs stimulated with Schistosoma mansoni soluble egg antigen (SEA), regardless of the subjects DQB1*0201 genotype or infection status. However, previously infected DQB1*0201 positive individuals had significantly lower levels of IgG4 compared to DQB1*0201 negative individuals (P < 0.05).HLASchistosomiaisisSchistosoma mansoniImmunoglobulin isotypeAntígenos HLA-DQ/genéticaPolimorfismo GenéticoSchistosoma mansoni/imunologiaEsquistossomose mansoni/genéticaEsquistossomose mansoni/imunologiaAdultoAnimaisAnticorpos Anti-Helmínticos/sangueCitocinas/secreçãoDoenças EndêmicasCadeias beta de HLA-DQHumanosLeucócitos Mononucleares/imunologiaMeia-IdadeEsquistossomose mansoni/epidemiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALReis EAG Influence of the HLA-DQB10201....pdfReis EAG Influence of the HLA-DQB10201....pdfapplication/pdf332665https://www.arca.fiocruz.br/bitstream/icict/7527/1/Reis%20EAG%20Influence%20of%20the%20HLA-DQB10201....pdfc82d469d2b2ba0d5ff6ef7d2b3052579MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7527/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTReis EAG Influence of the HLA-DQB10201....pdf.txtReis EAG Influence of the HLA-DQB10201....pdf.txtExtracted texttext/plain19504https://www.arca.fiocruz.br/bitstream/icict/7527/5/Reis%20EAG%20Influence%20of%20the%20HLA-DQB10201....pdf.txt1819e2b13ddb47a4b9f86a1c15420d74MD55THUMBNAILReis EAG Influence of the HLA-DQB10201....pdf.jpgReis EAG Influence of the HLA-DQB10201....pdf.jpgGenerated Thumbnailimage/jpeg2386https://www.arca.fiocruz.br/bitstream/icict/7527/4/Reis%20EAG%20Influence%20of%20the%20HLA-DQB10201....pdf.jpgdd402356c2187a77f9a30d55fe48f653MD54icict/75272023-03-15 14:33:17.414oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.
title Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.
spellingShingle Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.
Reis, Eliana Almeida Gomes
HLA
Schistosomiaisis
Schistosoma mansoni
Immunoglobulin isotype
Antígenos HLA-DQ/genética
Polimorfismo Genético
Schistosoma mansoni/imunologia
Esquistossomose mansoni/genética
Esquistossomose mansoni/imunologia
Adulto
Animais
Anticorpos Anti-Helmínticos/sangue
Citocinas/secreção
Doenças Endêmicas
Cadeias beta de HLA-DQ
Humanos
Leucócitos Mononucleares/imunologia
Meia-Idade
Esquistossomose mansoni/epidemiologia
title_short Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.
title_full Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.
title_fullStr Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.
title_full_unstemmed Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.
title_sort Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection.
author Reis, Eliana Almeida Gomes
author_facet Reis, Eliana Almeida Gomes
Athanazio, Daniel Abensur
McBride, Alan John Alexander
Carmo, Theomira Mauadie de Azevedo
Santos, Isis Fernandes Magalhães
Harn Junior, Donald A
Reis, Mitermayer Galvão dos
author_role author
author2 Athanazio, Daniel Abensur
McBride, Alan John Alexander
Carmo, Theomira Mauadie de Azevedo
Santos, Isis Fernandes Magalhães
Harn Junior, Donald A
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Eliana Almeida Gomes
Athanazio, Daniel Abensur
McBride, Alan John Alexander
Carmo, Theomira Mauadie de Azevedo
Santos, Isis Fernandes Magalhães
Harn Junior, Donald A
Reis, Mitermayer Galvão dos
dc.subject.en.pt_BR.fl_str_mv HLA
Schistosomiaisis
Schistosoma mansoni
Immunoglobulin isotype
topic HLA
Schistosomiaisis
Schistosoma mansoni
Immunoglobulin isotype
Antígenos HLA-DQ/genética
Polimorfismo Genético
Schistosoma mansoni/imunologia
Esquistossomose mansoni/genética
Esquistossomose mansoni/imunologia
Adulto
Animais
Anticorpos Anti-Helmínticos/sangue
Citocinas/secreção
Doenças Endêmicas
Cadeias beta de HLA-DQ
Humanos
Leucócitos Mononucleares/imunologia
Meia-Idade
Esquistossomose mansoni/epidemiologia
dc.subject.decs.pt_BR.fl_str_mv Antígenos HLA-DQ/genética
Polimorfismo Genético
Schistosoma mansoni/imunologia
Esquistossomose mansoni/genética
Esquistossomose mansoni/imunologia
Adulto
Animais
Anticorpos Anti-Helmínticos/sangue
Citocinas/secreção
Doenças Endêmicas
Cadeias beta de HLA-DQ
Humanos
Leucócitos Mononucleares/imunologia
Meia-Idade
Esquistossomose mansoni/epidemiologia
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-04-22T18:27:59Z
dc.date.available.fl_str_mv 2014-04-22T18:27:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, E. A. G. et al. Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection. Acta Tropica, v. 108, n. 2-3, p. 131-134, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7527
dc.identifier.issn.none.fl_str_mv 1873-6254
identifier_str_mv REIS, E. A. G. et al. Influence of the HLA-DQB1*0201 allele on the immune response in a Schistosoma mansoni infection. Acta Tropica, v. 108, n. 2-3, p. 131-134, 2008.
1873-6254
url https://www.arca.fiocruz.br/handle/icict/7527
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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