Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16773 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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Coutinho, R. B. G. AzeredoMatos, D. C. S.Nery, J. A. C.Rosalino, C. M. ValeteMendonça, S. C. F.2017-01-10T11:47:18Z2017-01-10T11:47:18Z2012COUTINHO, R. B. G. Azeredo et al. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection. Brazilian Journal of Medical and Biological Research, v. 45, p. 632-636, 2012.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/1677310.1590/S0100-879X20120075000731414-431XengAssociação Brasileira de Divulgação CientíficaLeishmaniose mucocutâneaHanseníaseHanseníase MultibacilarLeishmania braziliensisInterferon gamaInterleucina-10Interferon-gammaInterleukin-10Mucocutaneous leishmaniasisLepromatous leprosyLeishmania braziliensisMycobacterium lepraeInterleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Referência Nacional em Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.We have described a case of a patient with an intriguing association of mucocutaneous leishmaniasis with lepromatous leprosy, two opposite polar forms of these spectral diseases. In the present follow-up study, we investigated the effect of the addition of Mycobacterium leprae antigens on interferon-gamma (IFN-γ) production in Leishmania antigen-stimulated cultures of peripheral blood mononuclear cells (PBMC) from this patient. For this purpose, PBMC cultures were stimulated with crude L. braziliensis and/or M. leprae whole-cell antigen extracts or with concanavalin A. In some experiments, neutralizing anti-human interleukin (IL)-10 antibodies were added to the cultures. IFN-γ and IL-10 levels in culture supernatants were measured by ELISA. During active leprosy, M. leprae antigens induced 72.3% suppression of the IFN-γ response to L. braziliensis antigen, and this suppression was abolished by IL-10 neutralization. Interestingly, the suppressive effect of M. leprae antigen was lost after the cure of leprosy and the disappearance of this effect was accompanied by exacerbation of mucosal leishmaniasis. Considered together, these results provide evidence that the concomitant lepromatous leprosy induced an IL-10-mediated regulatory response that controlled the immunopathology of mucosal leishmaniasis, demonstrating that, in the context of this coinfection, the specific immune response to one pathogen can influence the immune response to the other pathogen and the clinical course of the disease caused by it. Our findings may contribute to a better understanding of the Leishmania/M. leprae coinfection and of the immunopathogenesis of mucosal leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16773/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjac_nery_etal_IOC_2012.pdfjac_nery_etal_IOC_2012.pdfapplication/pdf1872740https://www.arca.fiocruz.br/bitstream/icict/16773/2/jac_nery_etal_IOC_2012.pdf479aab442de09957493e5ab2c8a2ea44MD52TEXTjac_nery_etal_IOC_2012.pdf.txtjac_nery_etal_IOC_2012.pdf.txtExtracted texttext/plain24583https://www.arca.fiocruz.br/bitstream/icict/16773/3/jac_nery_etal_IOC_2012.pdf.txtfb240a2e801060ecd5dc4f034e56b6eaMD53icict/167732019-11-13 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dc.title.pt_BR.fl_str_mv |
Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection |
title |
Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection |
spellingShingle |
Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection Coutinho, R. B. G. Azeredo Leishmaniose mucocutânea Hanseníase Hanseníase Multibacilar Leishmania braziliensis Interferon gama Interleucina-10 Interferon-gamma Interleukin-10 Mucocutaneous leishmaniasis Lepromatous leprosy Leishmania braziliensis Mycobacterium leprae |
title_short |
Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection |
title_full |
Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection |
title_fullStr |
Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection |
title_full_unstemmed |
Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection |
title_sort |
Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection |
author |
Coutinho, R. B. G. Azeredo |
author_facet |
Coutinho, R. B. G. Azeredo Matos, D. C. S. Nery, J. A. C. Rosalino, C. M. Valete Mendonça, S. C. F. |
author_role |
author |
author2 |
Matos, D. C. S. Nery, J. A. C. Rosalino, C. M. Valete Mendonça, S. C. F. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Coutinho, R. B. G. Azeredo Matos, D. C. S. Nery, J. A. C. Rosalino, C. M. Valete Mendonça, S. C. F. |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose mucocutânea Hanseníase Hanseníase Multibacilar Leishmania braziliensis Interferon gama Interleucina-10 |
topic |
Leishmaniose mucocutânea Hanseníase Hanseníase Multibacilar Leishmania braziliensis Interferon gama Interleucina-10 Interferon-gamma Interleukin-10 Mucocutaneous leishmaniasis Lepromatous leprosy Leishmania braziliensis Mycobacterium leprae |
dc.subject.en.pt_BR.fl_str_mv |
Interferon-gamma Interleukin-10 Mucocutaneous leishmaniasis Lepromatous leprosy Leishmania braziliensis Mycobacterium leprae |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2017-01-10T11:47:18Z |
dc.date.available.fl_str_mv |
2017-01-10T11:47:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COUTINHO, R. B. G. Azeredo et al. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection. Brazilian Journal of Medical and Biological Research, v. 45, p. 632-636, 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/16773 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-879X |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2012007500073 |
dc.identifier.eissn.none.fl_str_mv |
1414-431X |
identifier_str_mv |
COUTINHO, R. B. G. Azeredo et al. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection. Brazilian Journal of Medical and Biological Research, v. 45, p. 632-636, 2012. 0100-879X 10.1590/S0100-879X2012007500073 1414-431X |
url |
https://www.arca.fiocruz.br/handle/icict/16773 |
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eng |
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eng |
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openAccess |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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