Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection

Detalhes bibliográficos
Autor(a) principal: Coutinho, R. B. G. Azeredo
Data de Publicação: 2012
Outros Autores: Matos, D. C. S., Nery, J. A. C., Rosalino, C. M. Valete, Mendonça, S. C. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16773
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
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spelling Coutinho, R. B. G. AzeredoMatos, D. C. S.Nery, J. A. C.Rosalino, C. M. ValeteMendonça, S. C. F.2017-01-10T11:47:18Z2017-01-10T11:47:18Z2012COUTINHO, R. B. G. Azeredo et al. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection. Brazilian Journal of Medical and Biological Research, v. 45, p. 632-636, 2012.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/1677310.1590/S0100-879X20120075000731414-431XengAssociação Brasileira de Divulgação CientíficaLeishmaniose mucocutâneaHanseníaseHanseníase MultibacilarLeishmania braziliensisInterferon gamaInterleucina-10Interferon-gammaInterleukin-10Mucocutaneous leishmaniasisLepromatous leprosyLeishmania braziliensisMycobacterium lepraeInterleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Referência Nacional em Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.We have described a case of a patient with an intriguing association of mucocutaneous leishmaniasis with lepromatous leprosy, two opposite polar forms of these spectral diseases. In the present follow-up study, we investigated the effect of the addition of Mycobacterium leprae antigens on interferon-gamma (IFN-γ) production in Leishmania antigen-stimulated cultures of peripheral blood mononuclear cells (PBMC) from this patient. For this purpose, PBMC cultures were stimulated with crude L. braziliensis and/or M. leprae whole-cell antigen extracts or with concanavalin A. In some experiments, neutralizing anti-human interleukin (IL)-10 antibodies were added to the cultures. IFN-γ and IL-10 levels in culture supernatants were measured by ELISA. During active leprosy, M. leprae antigens induced 72.3% suppression of the IFN-γ response to L. braziliensis antigen, and this suppression was abolished by IL-10 neutralization. Interestingly, the suppressive effect of M. leprae antigen was lost after the cure of leprosy and the disappearance of this effect was accompanied by exacerbation of mucosal leishmaniasis. Considered together, these results provide evidence that the concomitant lepromatous leprosy induced an IL-10-mediated regulatory response that controlled the immunopathology of mucosal leishmaniasis, demonstrating that, in the context of this coinfection, the specific immune response to one pathogen can influence the immune response to the other pathogen and the clinical course of the disease caused by it. Our findings may contribute to a better understanding of the Leishmania/M. leprae coinfection and of the immunopathogenesis of mucosal leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16773/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjac_nery_etal_IOC_2012.pdfjac_nery_etal_IOC_2012.pdfapplication/pdf1872740https://www.arca.fiocruz.br/bitstream/icict/16773/2/jac_nery_etal_IOC_2012.pdf479aab442de09957493e5ab2c8a2ea44MD52TEXTjac_nery_etal_IOC_2012.pdf.txtjac_nery_etal_IOC_2012.pdf.txtExtracted texttext/plain24583https://www.arca.fiocruz.br/bitstream/icict/16773/3/jac_nery_etal_IOC_2012.pdf.txtfb240a2e801060ecd5dc4f034e56b6eaMD53icict/167732019-11-13 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dc.title.pt_BR.fl_str_mv Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
title Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
spellingShingle Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
Coutinho, R. B. G. Azeredo
Leishmaniose mucocutânea
Hanseníase
Hanseníase Multibacilar
Leishmania braziliensis
Interferon gama
Interleucina-10
Interferon-gamma
Interleukin-10
Mucocutaneous leishmaniasis
Lepromatous leprosy
Leishmania braziliensis
Mycobacterium leprae
title_short Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
title_full Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
title_fullStr Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
title_full_unstemmed Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
title_sort Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection
author Coutinho, R. B. G. Azeredo
author_facet Coutinho, R. B. G. Azeredo
Matos, D. C. S.
Nery, J. A. C.
Rosalino, C. M. Valete
Mendonça, S. C. F.
author_role author
author2 Matos, D. C. S.
Nery, J. A. C.
Rosalino, C. M. Valete
Mendonça, S. C. F.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Coutinho, R. B. G. Azeredo
Matos, D. C. S.
Nery, J. A. C.
Rosalino, C. M. Valete
Mendonça, S. C. F.
dc.subject.other.pt_BR.fl_str_mv Leishmaniose mucocutânea
Hanseníase
Hanseníase Multibacilar
Leishmania braziliensis
Interferon gama
Interleucina-10
topic Leishmaniose mucocutânea
Hanseníase
Hanseníase Multibacilar
Leishmania braziliensis
Interferon gama
Interleucina-10
Interferon-gamma
Interleukin-10
Mucocutaneous leishmaniasis
Lepromatous leprosy
Leishmania braziliensis
Mycobacterium leprae
dc.subject.en.pt_BR.fl_str_mv Interferon-gamma
Interleukin-10
Mucocutaneous leishmaniasis
Lepromatous leprosy
Leishmania braziliensis
Mycobacterium leprae
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-01-10T11:47:18Z
dc.date.available.fl_str_mv 2017-01-10T11:47:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv COUTINHO, R. B. G. Azeredo et al. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection. Brazilian Journal of Medical and Biological Research, v. 45, p. 632-636, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16773
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.doi.none.fl_str_mv 10.1590/S0100-879X2012007500073
dc.identifier.eissn.none.fl_str_mv 1414-431X
identifier_str_mv COUTINHO, R. B. G. Azeredo et al. Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection. Brazilian Journal of Medical and Biological Research, v. 45, p. 632-636, 2012.
0100-879X
10.1590/S0100-879X2012007500073
1414-431X
url https://www.arca.fiocruz.br/handle/icict/16773
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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