Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?

Detalhes bibliográficos
Autor(a) principal: Hottz, Eugenio D.
Data de Publicação: 2015
Outros Autores: Monteiro, Ana Paula T., Bozza, Fernando A., Bozza, Patrícia T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11498
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.
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spelling Hottz, Eugenio D.Monteiro, Ana Paula T.Bozza, Fernando A.Bozza, Patrícia T.2015-08-19T13:49:22Z2015-08-19T13:49:22Z2015HOTTZ, Eugenio D.; et al. Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?. Mediators of Inflammation, v.2015, Article ID 435783, 7p, 2015.0962-9351https://www.arca.fiocruz.br/handle/icict/1149810.1155/2015/435783engHindawi Publishing CorporationDoenças InflamatóriasInflamationPlateletsHemotasisPlaquetasInflamaçãoHemostasiaInflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil / Instituto D`Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Platelets are crucial effector cells in hemostasis. In addition, platelets are increasingly recognized as major inflammatory cells with key roles in innate and adaptive immune responses. Activated platelets have key thromboinflammatory activities linking coagulation to inflammatory response in a variety of coagulation disorders and vasculopathies. Recently identified inflammatory activities of platelets include the synthesis of IL-1 from spliced pre-RNA, as well as the presence and assembly of inflammasome which intermediate IL-1 secretion. Here we review the mechanisms by which platelets activate translation machinery and inflammasome assembly to synthesize and release IL-1. The contributions of these processes to protective and pathogenic responses during infectious and inflammatory diseases are discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11498/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALeugenio_hottz_etal_IOC-215.pdfapplication/pdf1737799https://www.arca.fiocruz.br/bitstream/icict/11498/2/eugenio_hottz_etal_IOC-215.pdfca7ac61e83a689d21b2ff024e5268709MD52TEXTeugenio_hottz_etal_IOC-215.pdf.txteugenio_hottz_etal_IOC-215.pdf.txtExtracted texttext/plain37608https://www.arca.fiocruz.br/bitstream/icict/11498/3/eugenio_hottz_etal_IOC-215.pdf.txt6d2e6209d4318626a7eb41a7fa32092bMD53icict/114982022-06-24 12:18:58.464oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:18:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
title Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
spellingShingle Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
Hottz, Eugenio D.
Doenças Inflamatórias
Inflamation
Platelets
Hemotasis
Plaquetas
Inflamação
Hemostasia
title_short Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
title_full Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
title_fullStr Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
title_full_unstemmed Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
title_sort Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?
author Hottz, Eugenio D.
author_facet Hottz, Eugenio D.
Monteiro, Ana Paula T.
Bozza, Fernando A.
Bozza, Patrícia T.
author_role author
author2 Monteiro, Ana Paula T.
Bozza, Fernando A.
Bozza, Patrícia T.
author2_role author
author
author
dc.contributor.author.fl_str_mv Hottz, Eugenio D.
Monteiro, Ana Paula T.
Bozza, Fernando A.
Bozza, Patrícia T.
dc.subject.other.pt_BR.fl_str_mv Doenças Inflamatórias
topic Doenças Inflamatórias
Inflamation
Platelets
Hemotasis
Plaquetas
Inflamação
Hemostasia
dc.subject.en.pt_BR.fl_str_mv Inflamation
Platelets
Hemotasis
dc.subject.decs.pt_BR.fl_str_mv Plaquetas
Inflamação
Hemostasia
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-08-19T13:49:22Z
dc.date.available.fl_str_mv 2015-08-19T13:49:22Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HOTTZ, Eugenio D.; et al. Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?. Mediators of Inflammation, v.2015, Article ID 435783, 7p, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11498
dc.identifier.issn.pt_BR.fl_str_mv 0962-9351
dc.identifier.doi.pt_BR.fl_str_mv 10.1155/2015/435783
identifier_str_mv HOTTZ, Eugenio D.; et al. Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?. Mediators of Inflammation, v.2015, Article ID 435783, 7p, 2015.
0962-9351
10.1155/2015/435783
url https://www.arca.fiocruz.br/handle/icict/11498
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/11498/3/eugenio_hottz_etal_IOC-215.pdf.txt
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