Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study

Detalhes bibliográficos
Autor(a) principal: Andrade, Sonia Gumes
Data de Publicação: 1987
Outros Autores: Silva, R. C., Santiago, Christiane Maria Gaspar, Freitas, Luiz Antonio Rodrigues de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7912
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Andrade, Sonia GumesSilva, R. C.Santiago, Christiane Maria GasparFreitas, Luiz Antonio Rodrigues de2014-07-10T18:15:19Z2014-07-10T18:15:19Z1987ANDRADE, S. G. et al. Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study. Bulletin of the World Health Organization, v. 65, n. 5, p. 625-633, 1987.0042-9686https://www.arca.fiocruz.br/handle/icict/7912engWorld Health OrganizationTherapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.The anti-protozoal drug MK-436 (3-(J-methyl-5-nitroimidazol-2-yl)-3a,4,5,6,7,7ahexahydro-1,2-benzisoxazole) was found to be effective against Trypanosoma cruzi infections in mice (2 daily doses of250 mg per kg body weight). Parasitaemia disappeared within 24 hours oftreatment which was commenced during the early or late stages ofacute infection. Intracellular T. cruzi parasites were also affected by the drug, ultrastructural findings showing severe cytoplasmic vacuolization and membrane alterations. Positive serological responses persisted in the majority oftreated and parasitologically cured mice in the study. Cure rates varied from 72% to 100% and were similar regardless of the T. cruzi strain used (Y strain, type 1; 12 SF strain, type II; or Colombian strain, type III). However, the proportion ofpositive serological tests and the frequency of inflammatory lesions were greatestfor mice that were infected with the Colombian strain ofthe parasite.Doença de Chagas/quimioterapiaModelos Animais de DoençasNitroimidazóis/uso terapêuticoTripanossomicidas/uso terapêuticoAnimaisCardiomiopatia Chagásica/parasitologiaCardiomiopatia Chagásica/patologiaDoença de Chagas/parasitologiaDoença de Chagas/patologiaFemininoMasculinoCamundongosMiocárdio/ultraestruturaTripanossomicidas/farmacologiaTrypanosoma cruzi/efeitos de drogasTrypanosoma cruzi/ultraestruturainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade SG Therapeutic action....pdfAndrade SG Therapeutic action....pdfapplication/pdf1404557https://www.arca.fiocruz.br/bitstream/icict/7912/1/Andrade%20SG%20Therapeutic%20action....pdf770d5c593b214b09478235e452c58cabMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7912/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTAndrade SG Therapeutic action....pdf.txtAndrade SG Therapeutic action....pdf.txtExtracted texttext/plain29385https://www.arca.fiocruz.br/bitstream/icict/7912/3/Andrade%20SG%20Therapeutic%20action....pdf.txt5922f06925c6d38fb866d199fa10deefMD53icict/79122023-03-15 14:33:17.515oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
title Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
spellingShingle Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
Andrade, Sonia Gumes
Doença de Chagas/quimioterapia
Modelos Animais de Doenças
Nitroimidazóis/uso terapêutico
Tripanossomicidas/uso terapêutico
Animais
Cardiomiopatia Chagásica/parasitologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/parasitologia
Doença de Chagas/patologia
Feminino
Masculino
Camundongos
Miocárdio/ultraestrutura
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos de drogas
Trypanosoma cruzi/ultraestrutura
title_short Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
title_full Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
title_fullStr Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
title_full_unstemmed Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
title_sort Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study
author Andrade, Sonia Gumes
author_facet Andrade, Sonia Gumes
Silva, R. C.
Santiago, Christiane Maria Gaspar
Freitas, Luiz Antonio Rodrigues de
author_role author
author2 Silva, R. C.
Santiago, Christiane Maria Gaspar
Freitas, Luiz Antonio Rodrigues de
author2_role author
author
author
dc.contributor.author.fl_str_mv Andrade, Sonia Gumes
Silva, R. C.
Santiago, Christiane Maria Gaspar
Freitas, Luiz Antonio Rodrigues de
dc.subject.decs.pt_BR.fl_str_mv Doença de Chagas/quimioterapia
Modelos Animais de Doenças
Nitroimidazóis/uso terapêutico
Tripanossomicidas/uso terapêutico
Animais
Cardiomiopatia Chagásica/parasitologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/parasitologia
Doença de Chagas/patologia
Feminino
Masculino
Camundongos
Miocárdio/ultraestrutura
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos de drogas
Trypanosoma cruzi/ultraestrutura
topic Doença de Chagas/quimioterapia
Modelos Animais de Doenças
Nitroimidazóis/uso terapêutico
Tripanossomicidas/uso terapêutico
Animais
Cardiomiopatia Chagásica/parasitologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/parasitologia
Doença de Chagas/patologia
Feminino
Masculino
Camundongos
Miocárdio/ultraestrutura
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos de drogas
Trypanosoma cruzi/ultraestrutura
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 1987
dc.date.issued.fl_str_mv 1987
dc.date.accessioned.fl_str_mv 2014-07-10T18:15:19Z
dc.date.available.fl_str_mv 2014-07-10T18:15:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, S. G. et al. Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study. Bulletin of the World Health Organization, v. 65, n. 5, p. 625-633, 1987.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7912
dc.identifier.issn.none.fl_str_mv 0042-9686
identifier_str_mv ANDRADE, S. G. et al. Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study. Bulletin of the World Health Organization, v. 65, n. 5, p. 625-633, 1987.
0042-9686
url https://www.arca.fiocruz.br/handle/icict/7912
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv World Health Organization
publisher.none.fl_str_mv World Health Organization
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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