Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1996 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5695 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Souza, Márcia Maria deAndrade, Sonia GumesBarbosa Junior, Aryon de AlmeidaSantos, Raimunda Telma MacedoAlves, Venâncio Avancini FerreiraAndrade, Zilton de Araújo2012-10-19T19:46:33Z2012-10-19T19:46:33Z1996de SOUZA, M.M. et al. Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 91, n. 2, p. 217-24, mar.-apr. 1996.0074-0276https://www.arca.fiocruz.br/handle/icict/5695engTrypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilInstituto Adolfo Lutz. São Paulo, SP, BrasilInstituto Adolfo Lutz. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLesions involving the sympathetic (para-vertebral ganglia) and para-sympathetic ganglia of intestines (Auerbach plexus) and heart (right atrial ganglia) were comparatively analyzed in mice infected with either of three different strain types of Trypanosoma cruzi, during acute and chronic infection, in an attempt to understand the influence of parasite strain in causing autonomic nervous system pathology. Ganglionar involvement with neuronal destruction appeared related to inflammation, which most of the times extended from neighboring adipose and cardiac, smooth and striated muscular tissues. Intraganglionic parasitism was exceptional. Inflammation involving peripheral nervous tissue exhibited a focal character and its variability in the several groups examined appeared unpredictable. Although lesions were generally more severe with the Y strain, comparative qualitative study did not allow the conclusion, under the present experimental conditions, that one strain was more pathogenic to the autonomic nervous system than others. No special tropism of the parasites from any strain toward autonomic ganglia was disclosed.Trypanosoma cruziStrain-typesAutonomic nervous systemSistema Nervoso Autônomo/patologiaDoença de Chagas/patologiaTrypanosoma cruzi/classificaçãoAnimaisSistema Nervoso Autônomo/parasitologiaCardiomiopatia Chagásica/parasitologiaCardiomiopatia Chagásica/patologiaDoença de Chagas/parasitologiaModelos Animais de DoençasFemininoMasculinoCamundongosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSouza MM Trypanosoma cruzi strains....pdfSouza MM Trypanosoma cruzi strains....pdfapplication/pdf626348https://www.arca.fiocruz.br/bitstream/icict/5695/1/Souza%20MM%20Trypanosoma%20cruzi%20strains....pdffbb2680fb6d4d5acbd22444f56ba322fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5695/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTSouza MM Trypanosoma cruzi strains....pdf.txtSouza MM Trypanosoma cruzi strains....pdf.txtExtracted texttext/plain25969https://www.arca.fiocruz.br/bitstream/icict/5695/5/Souza%20MM%20Trypanosoma%20cruzi%20strains....pdf.txt3d520ff46a45ff2d0c11175edc225328MD55THUMBNAILSouza MM Trypanosoma cruzi strains....pdf.jpgSouza MM Trypanosoma cruzi strains....pdf.jpgGenerated Thumbnailimage/jpeg2361https://www.arca.fiocruz.br/bitstream/icict/5695/4/Souza%20MM%20Trypanosoma%20cruzi%20strains....pdf.jpg5ee027155aa68ae28c8b762949395d57MD54icict/56952023-03-15 14:33:13.806oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:13Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. |
| title |
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. |
| spellingShingle |
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Souza, Márcia Maria de Trypanosoma cruzi Strain-types Autonomic nervous system Sistema Nervoso Autônomo/patologia Doença de Chagas/patologia Trypanosoma cruzi/classificação Animais Sistema Nervoso Autônomo/parasitologia Cardiomiopatia Chagásica/parasitologia Cardiomiopatia Chagásica/patologia Doença de Chagas/parasitologia Modelos Animais de Doenças Feminino Masculino Camundongos |
| title_short |
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. |
| title_full |
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. |
| title_fullStr |
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. |
| title_full_unstemmed |
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. |
| title_sort |
Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. |
| author |
Souza, Márcia Maria de |
| author_facet |
Souza, Márcia Maria de Andrade, Sonia Gumes Barbosa Junior, Aryon de Almeida Santos, Raimunda Telma Macedo Alves, Venâncio Avancini Ferreira Andrade, Zilton de Araújo |
| author_role |
author |
| author2 |
Andrade, Sonia Gumes Barbosa Junior, Aryon de Almeida Santos, Raimunda Telma Macedo Alves, Venâncio Avancini Ferreira Andrade, Zilton de Araújo |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Márcia Maria de Andrade, Sonia Gumes Barbosa Junior, Aryon de Almeida Santos, Raimunda Telma Macedo Alves, Venâncio Avancini Ferreira Andrade, Zilton de Araújo |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Strain-types Autonomic nervous system |
| topic |
Trypanosoma cruzi Strain-types Autonomic nervous system Sistema Nervoso Autônomo/patologia Doença de Chagas/patologia Trypanosoma cruzi/classificação Animais Sistema Nervoso Autônomo/parasitologia Cardiomiopatia Chagásica/parasitologia Cardiomiopatia Chagásica/patologia Doença de Chagas/parasitologia Modelos Animais de Doenças Feminino Masculino Camundongos |
| dc.subject.decs.pt_BR.fl_str_mv |
Sistema Nervoso Autônomo/patologia Doença de Chagas/patologia Trypanosoma cruzi/classificação Animais Sistema Nervoso Autônomo/parasitologia Cardiomiopatia Chagásica/parasitologia Cardiomiopatia Chagásica/patologia Doença de Chagas/parasitologia Modelos Animais de Doenças Feminino Masculino Camundongos |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
1996 |
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1996 |
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2012-10-19T19:46:33Z |
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2012-10-19T19:46:33Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
de SOUZA, M.M. et al. Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 91, n. 2, p. 217-24, mar.-apr. 1996. |
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https://www.arca.fiocruz.br/handle/icict/5695 |
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0074-0276 |
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de SOUZA, M.M. et al. Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 91, n. 2, p. 217-24, mar.-apr. 1996. 0074-0276 |
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