Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.

Detalhes bibliográficos
Autor(a) principal: Souza, Márcia Maria de
Data de Publicação: 1996
Outros Autores: Andrade, Sonia Gumes, Barbosa Junior, Aryon de Almeida, Santos, Raimunda Telma Macedo, Alves, Venâncio Avancini Ferreira, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5695
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Souza, Márcia Maria deAndrade, Sonia GumesBarbosa Junior, Aryon de AlmeidaSantos, Raimunda Telma MacedoAlves, Venâncio Avancini FerreiraAndrade, Zilton de Araújo2012-10-19T19:46:33Z2012-10-19T19:46:33Z1996de SOUZA, M.M. et al. Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 91, n. 2, p. 217-24, mar.-apr. 1996.0074-0276https://www.arca.fiocruz.br/handle/icict/5695engTrypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilInstituto Adolfo Lutz. São Paulo, SP, BrasilInstituto Adolfo Lutz. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLesions involving the sympathetic (para-vertebral ganglia) and para-sympathetic ganglia of intestines (Auerbach plexus) and heart (right atrial ganglia) were comparatively analyzed in mice infected with either of three different strain types of Trypanosoma cruzi, during acute and chronic infection, in an attempt to understand the influence of parasite strain in causing autonomic nervous system pathology. Ganglionar involvement with neuronal destruction appeared related to inflammation, which most of the times extended from neighboring adipose and cardiac, smooth and striated muscular tissues. Intraganglionic parasitism was exceptional. Inflammation involving peripheral nervous tissue exhibited a focal character and its variability in the several groups examined appeared unpredictable. Although lesions were generally more severe with the Y strain, comparative qualitative study did not allow the conclusion, under the present experimental conditions, that one strain was more pathogenic to the autonomic nervous system than others. No special tropism of the parasites from any strain toward autonomic ganglia was disclosed.Trypanosoma cruziStrain-typesAutonomic nervous systemSistema Nervoso Autônomo/patologiaDoença de Chagas/patologiaTrypanosoma cruzi/classificaçãoAnimaisSistema Nervoso Autônomo/parasitologiaCardiomiopatia Chagásica/parasitologiaCardiomiopatia Chagásica/patologiaDoença de Chagas/parasitologiaModelos Animais de DoençasFemininoMasculinoCamundongosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSouza MM Trypanosoma cruzi strains....pdfSouza MM Trypanosoma cruzi strains....pdfapplication/pdf626348https://www.arca.fiocruz.br/bitstream/icict/5695/1/Souza%20MM%20Trypanosoma%20cruzi%20strains....pdffbb2680fb6d4d5acbd22444f56ba322fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5695/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTSouza MM Trypanosoma cruzi strains....pdf.txtSouza MM Trypanosoma cruzi strains....pdf.txtExtracted texttext/plain25969https://www.arca.fiocruz.br/bitstream/icict/5695/5/Souza%20MM%20Trypanosoma%20cruzi%20strains....pdf.txt3d520ff46a45ff2d0c11175edc225328MD55THUMBNAILSouza MM Trypanosoma cruzi strains....pdf.jpgSouza MM Trypanosoma cruzi strains....pdf.jpgGenerated Thumbnailimage/jpeg2361https://www.arca.fiocruz.br/bitstream/icict/5695/4/Souza%20MM%20Trypanosoma%20cruzi%20strains....pdf.jpg5ee027155aa68ae28c8b762949395d57MD54icict/56952023-03-15 14:33:13.806oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:13Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
title Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
spellingShingle Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
Souza, Márcia Maria de
Trypanosoma cruzi
Strain-types
Autonomic nervous system
Sistema Nervoso Autônomo/patologia
Doença de Chagas/patologia
Trypanosoma cruzi/classificação
Animais
Sistema Nervoso Autônomo/parasitologia
Cardiomiopatia Chagásica/parasitologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/parasitologia
Modelos Animais de Doenças
Feminino
Masculino
Camundongos
title_short Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
title_full Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
title_fullStr Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
title_full_unstemmed Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
title_sort Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease.
author Souza, Márcia Maria de
author_facet Souza, Márcia Maria de
Andrade, Sonia Gumes
Barbosa Junior, Aryon de Almeida
Santos, Raimunda Telma Macedo
Alves, Venâncio Avancini Ferreira
Andrade, Zilton de Araújo
author_role author
author2 Andrade, Sonia Gumes
Barbosa Junior, Aryon de Almeida
Santos, Raimunda Telma Macedo
Alves, Venâncio Avancini Ferreira
Andrade, Zilton de Araújo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Márcia Maria de
Andrade, Sonia Gumes
Barbosa Junior, Aryon de Almeida
Santos, Raimunda Telma Macedo
Alves, Venâncio Avancini Ferreira
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Strain-types
Autonomic nervous system
topic Trypanosoma cruzi
Strain-types
Autonomic nervous system
Sistema Nervoso Autônomo/patologia
Doença de Chagas/patologia
Trypanosoma cruzi/classificação
Animais
Sistema Nervoso Autônomo/parasitologia
Cardiomiopatia Chagásica/parasitologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/parasitologia
Modelos Animais de Doenças
Feminino
Masculino
Camundongos
dc.subject.decs.pt_BR.fl_str_mv Sistema Nervoso Autônomo/patologia
Doença de Chagas/patologia
Trypanosoma cruzi/classificação
Animais
Sistema Nervoso Autônomo/parasitologia
Cardiomiopatia Chagásica/parasitologia
Cardiomiopatia Chagásica/patologia
Doença de Chagas/parasitologia
Modelos Animais de Doenças
Feminino
Masculino
Camundongos
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2012-10-19T19:46:33Z
dc.date.available.fl_str_mv 2012-10-19T19:46:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv de SOUZA, M.M. et al. Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 91, n. 2, p. 217-24, mar.-apr. 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5695
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv de SOUZA, M.M. et al. Trypanosoma cruzi strains and autonomic nervous system pathology in experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v. 91, n. 2, p. 217-24, mar.-apr. 1996.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5695
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