Monocyte subsets in schistosomiasis patients with periportal fibrosis

Detalhes bibliográficos
Autor(a) principal: Fernandes, Jamille Souza
Data de Publicação: 2014
Outros Autores: Araujo, Maria Ilma, Lopes, Diego Mota, Souza, Robson da Paixão de, Carvalho Filho, Edgar Marcelino, Cardoso, Luciana Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24924
Resumo: CARVALHO FILHO, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Fernandes, Jamille SouzaAraujo, Maria IlmaLopes, Diego MotaSouza, Robson da Paixão deCarvalho Filho, Edgar MarcelinoCardoso, Luciana Santos2018-02-23T13:36:52Z2018-02-23T13:36:52Z2014FERNANDES, J. S. et al. Monocyte subsets in schistosomiasis patients with periportal fibrosis. Mediators of Inflammation, ID 703653, 2014.0962-9351https://www.arca.fiocruz.br/handle/icict/2492410.1155/2014/703653CARVALHO FILHO, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). This work was supported by the Brazilian National Research Council (CNPq) Universal (482113/2010-3).Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrazilUniversidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrazilUniversidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilA major issue with Schistosoma mansoni infection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens. Experimental studies have pointed to the participation of monocytes in the pathogenesis of liver fibrosis. The aim of this study was to characterize the subsets of monocytes in individuals with different degrees of periportal fibrosis secondary to schistosomiasis. Monocytes were classified into classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), and nonclassical (CD14(+)CD16(++)). The expressions of monocyte markers and cytokines were assessed using flow cytometry. The frequency of classical monocytes was higher than the other subsets. The expression of HLA-DR, IL-6, TNF-α, and TGF-β was higher in monocytes from individuals with moderate to severe fibrosis as compared to other groups. Although no differences were observed in receptors expression (IL-4R and IL-10R) between groups of patients, the expression of IL-12 was lower in monocytes from individuals with moderate to severe fibrosis, suggesting a protective role of this cytokine in the development of fibrosis. Our data support the hypothesis that the three different monocyte populations participate in the immunopathogenesis of periportal fibrosis, since they express high levels of proinflammatory and profibrotic cytokines and low levels of regulatory markers.engHindawi Publishing CorporationEsquistossomoseFibroseMonócitosCirrose hepáticaHumanosAdultoSchistosomiasisFibrosisMonocytesLiver CirrhosisHumansAdultMonocyte subsets in schistosomiasis patients with periportal fibrosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24924/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFernandes JS Monocyte Subsets in Schistosomiasis Patients....pdfFernandes JS Monocyte Subsets in Schistosomiasis 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dc.title.pt_BR.fl_str_mv Monocyte subsets in schistosomiasis patients with periportal fibrosis
title Monocyte subsets in schistosomiasis patients with periportal fibrosis
spellingShingle Monocyte subsets in schistosomiasis patients with periportal fibrosis
Fernandes, Jamille Souza
Esquistossomose
Fibrose
Monócitos
Cirrose hepática
Humanos
Adulto
Schistosomiasis
Fibrosis
Monocytes
Liver Cirrhosis
Humans
Adult
title_short Monocyte subsets in schistosomiasis patients with periportal fibrosis
title_full Monocyte subsets in schistosomiasis patients with periportal fibrosis
title_fullStr Monocyte subsets in schistosomiasis patients with periportal fibrosis
title_full_unstemmed Monocyte subsets in schistosomiasis patients with periportal fibrosis
title_sort Monocyte subsets in schistosomiasis patients with periportal fibrosis
author Fernandes, Jamille Souza
author_facet Fernandes, Jamille Souza
Araujo, Maria Ilma
Lopes, Diego Mota
Souza, Robson da Paixão de
Carvalho Filho, Edgar Marcelino
Cardoso, Luciana Santos
author_role author
author2 Araujo, Maria Ilma
Lopes, Diego Mota
Souza, Robson da Paixão de
Carvalho Filho, Edgar Marcelino
Cardoso, Luciana Santos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Jamille Souza
Araujo, Maria Ilma
Lopes, Diego Mota
Souza, Robson da Paixão de
Carvalho Filho, Edgar Marcelino
Cardoso, Luciana Santos
dc.subject.other.pt_BR.fl_str_mv Esquistossomose
Fibrose
Monócitos
Cirrose hepática
Humanos
Adulto
topic Esquistossomose
Fibrose
Monócitos
Cirrose hepática
Humanos
Adulto
Schistosomiasis
Fibrosis
Monocytes
Liver Cirrhosis
Humans
Adult
dc.subject.en.pt_BR.fl_str_mv Schistosomiasis
Fibrosis
Monocytes
Liver Cirrhosis
Humans
Adult
description CARVALHO FILHO, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2018-02-23T13:36:52Z
dc.date.available.fl_str_mv 2018-02-23T13:36:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERNANDES, J. S. et al. Monocyte subsets in schistosomiasis patients with periportal fibrosis. Mediators of Inflammation, ID 703653, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24924
dc.identifier.issn.pt_BR.fl_str_mv 0962-9351
dc.identifier.doi.none.fl_str_mv 10.1155/2014/703653
identifier_str_mv FERNANDES, J. S. et al. Monocyte subsets in schistosomiasis patients with periportal fibrosis. Mediators of Inflammation, ID 703653, 2014.
0962-9351
10.1155/2014/703653
url https://www.arca.fiocruz.br/handle/icict/24924
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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