Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | spa |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35118 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. |
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Souza, Veruska Cintia Alexandrino deMoura, Danielle Maria NascimentoCastro, Maria Carolina Accioly Brelaz deBozza, Patrícia TorresPaiva, Ligia de AlmeidaFernandes, Camila Juliet BarbosaLeão, Renata Lins CarneiroLucena, Jéssica PaulaAraujo, Roni Evencio deSilva, Alex José de MeloFigueiredo, Regina Celia Bressan QueirozOliveira, Sheilla Andrade de2019-08-27T16:12:39Z2019-08-27T16:12:39Z2019SOUZA, Veruska Cintia Alexandrino de et al. Adoptive Transfer of Bone Marrow- Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice. Scientific Reports, v. 9, n. 6434, p. 1-11, Apr. 2019.2045-2322https://www.arca.fiocruz.br/handle/icict/3511810.1038/s41598-019-42703-yspaNature ResearchSchistosoma mansoniMonócitosMedula ósseaFibrose hepáticaRatosSchistosoma mansoniBone MarrowLiver FibrosisMonocytesMiceAdoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Universidade Federal de Pernambuco. Centro Acadêmico de Vitória. Vitória de Santo Antão, PE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Liver diseases are a major health problem worldwide leading to high mortality rates and causing a considerable economic burden in many countries. Cellular therapies as potential treatments for liver diseases have proven beneficial in most of the conditions. In recent years, studies involving therapy with bone marrow cells have been implemented to promote liver regeneration and to reduce hepatic fibrosis, however identifying the cell population present in the bone marrow that is responsible for hepatic improvement after therapy is still necessary. The aim of the present study was the evaluation of the therapeutic efficacy of monocytes obtained from bone marrow in fibrosis resulting from S. mansoni infection in C57BL/6 mice. Monocytes were isolated by immunomagnetic separation and administered to the infected animals. The effects of treatment were evaluated through morphometric, biochemical, immunological and molecular analyzes. Monocyte therapy promoted reduction of liver fibrosis induced by S. mansoni infection, associated with a decrease in production of inflammatory and pro-fibrogenic mediators. In addition, monocyte infusion caused downregulation of factors associated with the M1 activation profile, as well as upregulation of M2reg markers. The findings altogether reinforce the hypothesis that the predominance of M2reg macrophages, producers of immunosuppressive cytokines, may favor the improvement of hepatic fibrosis in a preclinical model, through fibrous tissue remodeling, modulation of the inflammatory response and fibrogenesis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35118/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLigiaPaiva_PatriciaBozza_etal_IOC_2019.pdfLigiaPaiva_PatriciaBozza_etal_IOC_2019.pdfapplication/pdf2005612https://www.arca.fiocruz.br/bitstream/icict/35118/2/LigiaPaiva_PatriciaBozza_etal_IOC_2019.pdf2e2972526ba6a74ba6c014cbe3ab3614MD52TEXTLigiaPaiva_PatriciaBozza_etal_IOC_2019.pdf.txtLigiaPaiva_PatriciaBozza_etal_IOC_2019.pdf.txtExtracted 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Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice |
| title |
Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice |
| spellingShingle |
Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice Souza, Veruska Cintia Alexandrino de Schistosoma mansoni Monócitos Medula óssea Fibrose hepática Ratos Schistosoma mansoni Bone Marrow Liver Fibrosis Monocytes Mice |
| title_short |
Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice |
| title_full |
Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice |
| title_fullStr |
Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice |
| title_full_unstemmed |
Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice |
| title_sort |
Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice |
| author |
Souza, Veruska Cintia Alexandrino de |
| author_facet |
Souza, Veruska Cintia Alexandrino de Moura, Danielle Maria Nascimento Castro, Maria Carolina Accioly Brelaz de Bozza, Patrícia Torres Paiva, Ligia de Almeida Fernandes, Camila Juliet Barbosa Leão, Renata Lins Carneiro Lucena, Jéssica Paula Araujo, Roni Evencio de Silva, Alex José de Melo Figueiredo, Regina Celia Bressan Queiroz Oliveira, Sheilla Andrade de |
| author_role |
author |
| author2 |
Moura, Danielle Maria Nascimento Castro, Maria Carolina Accioly Brelaz de Bozza, Patrícia Torres Paiva, Ligia de Almeida Fernandes, Camila Juliet Barbosa Leão, Renata Lins Carneiro Lucena, Jéssica Paula Araujo, Roni Evencio de Silva, Alex José de Melo Figueiredo, Regina Celia Bressan Queiroz Oliveira, Sheilla Andrade de |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Veruska Cintia Alexandrino de Moura, Danielle Maria Nascimento Castro, Maria Carolina Accioly Brelaz de Bozza, Patrícia Torres Paiva, Ligia de Almeida Fernandes, Camila Juliet Barbosa Leão, Renata Lins Carneiro Lucena, Jéssica Paula Araujo, Roni Evencio de Silva, Alex José de Melo Figueiredo, Regina Celia Bressan Queiroz Oliveira, Sheilla Andrade de |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni Monócitos Medula óssea Fibrose hepática Ratos |
| topic |
Schistosoma mansoni Monócitos Medula óssea Fibrose hepática Ratos Schistosoma mansoni Bone Marrow Liver Fibrosis Monocytes Mice |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Bone Marrow Liver Fibrosis Monocytes Mice |
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Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. |
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2019 |
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2019-08-27T16:12:39Z |
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2019-08-27T16:12:39Z |
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2019 |
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SOUZA, Veruska Cintia Alexandrino de et al. Adoptive Transfer of Bone Marrow- Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice. Scientific Reports, v. 9, n. 6434, p. 1-11, Apr. 2019. |
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2045-2322 |
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10.1038/s41598-019-42703-y |
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SOUZA, Veruska Cintia Alexandrino de et al. Adoptive Transfer of Bone Marrow- Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice. Scientific Reports, v. 9, n. 6434, p. 1-11, Apr. 2019. 2045-2322 10.1038/s41598-019-42703-y |
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Nature Research |
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Nature Research |
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