Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.

Andrade, Bruno de Bezerril; Santos, Cristiane J. N; Camargo, Luis M; Souza Neto, Sebastião Martins; Reis Filho, Antonio José Souza; Clarêncio, Jorge; Mendonça, Vitor Rosa Ramos de; Luz, Nívea Farias; Camargo, Erney P; Barral, Aldina Maria Prado; Silva, Antonio Augusto Moura da; Barral Netto, Manoel

Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.

Detalhes bibliográficos
Autor(a) principal:	Andrade, Bruno de Bezerril
Data de Publicação:	2011
Outros Autores:	Santos, Cristiane J. N, Camargo, Luis M, Souza Neto, Sebastião Martins, Reis Filho, Antonio José Souza, Clarêncio, Jorge, Mendonça, Vitor Rosa Ramos de, Luz, Nívea Farias, Camargo, Erney P, Barral, Aldina Maria Prado, Silva, Antonio Augusto Moura da, Barral Netto, Manoel
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/5863
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil

Metadados do item

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spelling	Andrade, Bruno de BezerrilSantos, Cristiane J. NCamargo, Luis MSouza Neto, Sebastião MartinsReis Filho, Antonio José SouzaClarêncio, JorgeMendonça, Vitor Rosa Ramos deLuz, Nívea FariasCamargo, Erney PBarral, Aldina Maria PradoSilva, Antonio Augusto Moura daBarral Netto, Manoel2012-11-23T17:42:53Z2012-11-23T17:42:53Z2011ANDRADE, B.B. et al. Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon. PLoS One, v. 6, n. 5, p. e19841, 2011.1932-6203https://www.arca.fiocruz.br/handle/icict/586310.1371/journal.pone.0019841engHepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Maranhão. Centro de Ciências da Saúde. São Luis, MA, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAreas that are endemic for malaria are also highly endemic for hepatitis B virus (HBV) infection. Nevertheless, it is unknown whether HBV infection modifies the clinical presentation of malaria. This study aimed to address this question. METHODOLOGY AND FINDINGS: An observational study of 636 individuals was performed in Rondônia, western Amazon, Brazil between 2006 and 2007. Active and passive case detections identified Plasmodium infection by field microscopy and nested Polymerase Chain Reaction (PCR). HBV infections were identified by serology and confirmed by real-time PCR. Epidemiological information and plasma cytokine profiles were studied. The data were analyzed using adjusted multinomial logistic regression. Plasmodium-infected individuals with active HBV infection were more likely to be asymptomatic (OR: 120.13, P<0.0001), present with lower levels of parasitemia and demonstrate a decreased inflammatory cytokine profile. Nevertheless, co-infected individuals presented higher HBV viremia. Plasmodium parasitemia inversely correlated with plasma HBV DNA levels (râ€Š=â€Š-0.6; Pâ€Š=â€Š0.0003). CONCLUSION: HBV infection diminishes the intensity of malaria infection in individuals from this endemic area. This effect seems related to cytokine balance and control of inflammatory responses. These findings add important insights to the understanding of the factors affecting the clinical outcomes of malaria in endemic regions.Hepatite B/epidemiologiaHepatite B/etiologiaMalária/complicaçõesPlasmodium falciparum/patogenicidadePlasmodium vivax/patogenicidadeAdolescenteAdultoBrasil/epidemiologiaCriançaPré-EscolarCitocinas/metabolismoDNA Viral/genéticaFemininoHepatite B/diagnósticoAnticorpos Anti-Hepatite BAntígenos de Superfície da Hepatite BVírus da Hepatite B/genéticaHumanosMalária/virologiaMasculinoMeia-IdadeFatores de RiscoAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade BB Hepatitis B infection....pdfAndrade BB Hepatitis B infection....pdfapplication/pdf567831https://www.arca.fiocruz.br/bitstream/icict/5863/1/Andrade%20BB%20Hepatitis%20B%20infection....pdfd796007610dc2fac968013217086c99cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5863/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade BB Hepatitis B infection....pdf.txtAndrade BB Hepatitis B infection....pdf.txtExtracted texttext/plain39823https://www.arca.fiocruz.br/bitstream/icict/5863/5/Andrade%20BB%20Hepatitis%20B%20infection....pdf.txt606c0e1b0c534f7712eaa5617b0e4927MD55THUMBNAILAndrade BB Hepatitis B infection....pdf.jpgAndrade BB Hepatitis B infection....pdf.jpgGenerated Thumbnailimage/jpeg2402https://www.arca.fiocruz.br/bitstream/icict/5863/4/Andrade%20BB%20Hepatitis%20B%20infection....pdf.jpgd35b13e4719cc4cb0fdffe3f3083c6f4MD54icict/58632023-03-15 14:33:25.979oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
spellingShingle	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon. Andrade, Bruno de Bezerril Hepatite B/epidemiologia Hepatite B/etiologia Malária/complicações Plasmodium falciparum/patogenicidade Plasmodium vivax/patogenicidade Adolescente Adulto Brasil/epidemiologia Criança Pré-Escolar Citocinas/metabolismo DNA Viral/genética Feminino Hepatite B/diagnóstico Anticorpos Anti-Hepatite B Antígenos de Superfície da Hepatite B Vírus da Hepatite B/genética Humanos Malária/virologia Masculino Meia-Idade Fatores de Risco Adulto Jovem
title_short	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_full	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_fullStr	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_full_unstemmed	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
title_sort	Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.
author	Andrade, Bruno de Bezerril
author_facet	Andrade, Bruno de Bezerril Santos, Cristiane J. N Camargo, Luis M Souza Neto, Sebastião Martins Reis Filho, Antonio José Souza Clarêncio, Jorge Mendonça, Vitor Rosa Ramos de Luz, Nívea Farias Camargo, Erney P Barral, Aldina Maria Prado Silva, Antonio Augusto Moura da Barral Netto, Manoel
author_role	author
author2	Santos, Cristiane J. N Camargo, Luis M Souza Neto, Sebastião Martins Reis Filho, Antonio José Souza Clarêncio, Jorge Mendonça, Vitor Rosa Ramos de Luz, Nívea Farias Camargo, Erney P Barral, Aldina Maria Prado Silva, Antonio Augusto Moura da Barral Netto, Manoel
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Andrade, Bruno de Bezerril Santos, Cristiane J. N Camargo, Luis M Souza Neto, Sebastião Martins Reis Filho, Antonio José Souza Clarêncio, Jorge Mendonça, Vitor Rosa Ramos de Luz, Nívea Farias Camargo, Erney P Barral, Aldina Maria Prado Silva, Antonio Augusto Moura da Barral Netto, Manoel
dc.subject.decs.pt_BR.fl_str_mv	Hepatite B/epidemiologia Hepatite B/etiologia Malária/complicações Plasmodium falciparum/patogenicidade Plasmodium vivax/patogenicidade Adolescente Adulto Brasil/epidemiologia Criança Pré-Escolar Citocinas/metabolismo DNA Viral/genética Feminino Hepatite B/diagnóstico Anticorpos Anti-Hepatite B Antígenos de Superfície da Hepatite B Vírus da Hepatite B/genética Humanos Malária/virologia Masculino Meia-Idade Fatores de Risco Adulto Jovem
topic	Hepatite B/epidemiologia Hepatite B/etiologia Malária/complicações Plasmodium falciparum/patogenicidade Plasmodium vivax/patogenicidade Adolescente Adulto Brasil/epidemiologia Criança Pré-Escolar Citocinas/metabolismo DNA Viral/genética Feminino Hepatite B/diagnóstico Anticorpos Anti-Hepatite B Antígenos de Superfície da Hepatite B Vírus da Hepatite B/genética Humanos Malária/virologia Masculino Meia-Idade Fatores de Risco Adulto Jovem
description	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate	2011
dc.date.issued.fl_str_mv	2011
dc.date.accessioned.fl_str_mv	2012-11-23T17:42:53Z
dc.date.available.fl_str_mv	2012-11-23T17:42:53Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ANDRADE, B.B. et al. Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon. PLoS One, v. 6, n. 5, p. e19841, 2011.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/5863
dc.identifier.issn.none.fl_str_mv	1932-6203
dc.identifier.doi.none.fl_str_mv	10.1371/journal.pone.0019841
identifier_str_mv	ANDRADE, B.B. et al. Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon. PLoS One, v. 6, n. 5, p. e19841, 2011. 1932-6203 10.1371/journal.pone.0019841
url	https://www.arca.fiocruz.br/handle/icict/5863
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Hepatitis B infection is associated with asymptomatic malaria in the Brazilian Amazon.

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