Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41169 |
Resumo: | Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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Stefani, Mariane Martins AraújoRosa, Patricia SammarcoCosta, Mauricio BarcelosSchetinni, Antônio Pedro MendesManhães, IgorPontes, Maria Araci de AndradeCosta, PatriciaFachin, Luciana Raquel VincenziBaptista, Ida Maria Foschiani DiasVirmond, Marcos da Cunha LopesPereira, EmíliaPenna, Maria Lucia FernandesPenna, Gerson Oliveira2020-05-08T15:39:46Z2020-05-08T15:39:46Z2019STEFANI, Mariane Martins Araújo et al. Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil. Plos One, [San Francisco], v. 14, n. 1, p. 1-13, Jan. 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/4116910.1371/journal.pone.0209491Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.MS/DECIT/CNPqUniversidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Instituto Lauro de Souza Lima. Bauru, SP, Brasil.Universidade Federal de Goiás. Faculdade de Medicina. Goiânia, GO, Brasil.Fundação de Dermatologia Tropical e Venerologia Alfredo da Matta. Manaus, AM, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Dermatologia. Rio de Janeiro, RJ, Brasil.Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.Governo Municipal Coari. Secretaria Municipal de Saúde. Coari, AM, Brasil.Instituto Lauro de Souza Lima Bauru. São Paulo, SP, Brasil.Instituto Lauro de Souza Lima Bauru. São Paulo, SP, Brasil.Instituto Lauro de Souza Lima Bauru. São Paulo, SP, Brasil.Fundação de Dermatologia Tropical e Venerologia Alfredo da Matta. Manaus, AM, Brasil.Universidade Federal Fluminense. Departamento de Epidemiologia e Estatística. Niterói, RJ, Brasil.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil.There is evidence that in southern US, leprosy is a zoonosis infecting wild Dasypus novemcinctus armadillos but the extent of this finding is unknown. This ecological study investigated leprosy in rural communities and in wild armadillos from the Brazilian Amazon. The study area was the Mamiá Lake of Coari municipality, Amazonas State, Northern region, a hyper endemic leprosy area where residents live on subsistence farming, fishing and armadillo hunting and its meat intake are frequent. The leprosy survey was conducted in sixteen communities by a visiting team of specialists. Local partakers provided wild armadillos to investigate M. leprae infection. Volunteers had complete dermato-neurological examination by a dermatologist with expertise in leprosy diagnosis, suspect skin lesions were biopsied for histopathology (Hematoxylin-eosin/HE, Fite-Faraco/FF staining); slit skin smears were collected. Armadillos' tissue fragments (skins, spleens, livers, lymph nodes, adrenal glands, others) were prepared for histopathology (HE/FF) and for M. leprae repetitive element-RLEP-qPCR. Among 176 volunteers, six new indeterminate leprosy cases were identified (incidence = 3.4%). Suspect skin sections and slit skin smears were negative for bacilli. Twelve wild D. novemcinctus were investigated (48 specimens/96 slides) and histopathological features of M. leprae infection were not found, except for one skin presenting unspecific inflammatory infiltrate suggestive of indeterminate leprosy. Possible traumatic neuroma, granuloma with epithelioid and Langhans cells, foreign-body granuloma were also identified. Granulomatous/non-granulomatous dermatitides were periodic-acid-Schiff/PAS negative for fungus. M. leprae-RLEP-qPCR was negative in all armadillos' tissues; no bacillus was found in histopathology. Our survey in rural communities confirmed the high endemicity for leprosy while one armadillo was compatible with paucibacillary M. leprae infection. At least in the highly endemic rural area of Coari, in the Brazilian Amazon region where infectious sources from untreated multibacillary leprosy are abundant, M. leprae infected armadillos may not represent a major source of infection nor a significant public health concern.engPublic Library of ScienceDisease ReservoirsLeprosyLeprosy, PaucibacillaryMycobacterium lepraeRural PopulationSkin DiseasesSurveys and QuestionnairesZoonosesArmadillosBrazilSkin diseasesLeprosyLeprosy, paucibacillaryMycobacterium lepraeArmadillosZoonosesDermatopatiasMycobacterium lepraeHanseníaseDoenças TransmissíveisZoonosesPopulação RuralTatuLeprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil |
| title |
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil |
| spellingShingle |
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil Stefani, Mariane Martins Araújo Disease Reservoirs Leprosy Leprosy, Paucibacillary Mycobacterium leprae Rural Population Skin Diseases Surveys and Questionnaires Zoonoses Armadillos Brazil Skin diseases Leprosy Leprosy, paucibacillary Mycobacterium leprae Armadillos Zoonoses Dermatopatias Mycobacterium leprae Hanseníase Doenças Transmissíveis Zoonoses População Rural Tatu |
| title_short |
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil |
| title_full |
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil |
| title_fullStr |
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil |
| title_full_unstemmed |
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil |
| title_sort |
Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil |
| author |
Stefani, Mariane Martins Araújo |
| author_facet |
Stefani, Mariane Martins Araújo Rosa, Patricia Sammarco Costa, Mauricio Barcelos Schetinni, Antônio Pedro Mendes Manhães, Igor Pontes, Maria Araci de Andrade Costa, Patricia Fachin, Luciana Raquel Vincenzi Baptista, Ida Maria Foschiani Dias Virmond, Marcos da Cunha Lopes Pereira, Emília Penna, Maria Lucia Fernandes Penna, Gerson Oliveira |
| author_role |
author |
| author2 |
Rosa, Patricia Sammarco Costa, Mauricio Barcelos Schetinni, Antônio Pedro Mendes Manhães, Igor Pontes, Maria Araci de Andrade Costa, Patricia Fachin, Luciana Raquel Vincenzi Baptista, Ida Maria Foschiani Dias Virmond, Marcos da Cunha Lopes Pereira, Emília Penna, Maria Lucia Fernandes Penna, Gerson Oliveira |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Stefani, Mariane Martins Araújo Rosa, Patricia Sammarco Costa, Mauricio Barcelos Schetinni, Antônio Pedro Mendes Manhães, Igor Pontes, Maria Araci de Andrade Costa, Patricia Fachin, Luciana Raquel Vincenzi Baptista, Ida Maria Foschiani Dias Virmond, Marcos da Cunha Lopes Pereira, Emília Penna, Maria Lucia Fernandes Penna, Gerson Oliveira |
| dc.subject.mesh.pt_BR.fl_str_mv |
Disease Reservoirs Leprosy Leprosy, Paucibacillary Mycobacterium leprae Rural Population Skin Diseases Surveys and Questionnaires Zoonoses Armadillos Brazil |
| topic |
Disease Reservoirs Leprosy Leprosy, Paucibacillary Mycobacterium leprae Rural Population Skin Diseases Surveys and Questionnaires Zoonoses Armadillos Brazil Skin diseases Leprosy Leprosy, paucibacillary Mycobacterium leprae Armadillos Zoonoses Dermatopatias Mycobacterium leprae Hanseníase Doenças Transmissíveis Zoonoses População Rural Tatu |
| dc.subject.en.pt_BR.fl_str_mv |
Skin diseases Leprosy Leprosy, paucibacillary Mycobacterium leprae Armadillos Zoonoses |
| dc.subject.decs.pt_BR.fl_str_mv |
Dermatopatias Mycobacterium leprae Hanseníase Doenças Transmissíveis Zoonoses População Rural Tatu |
| description |
Gerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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2019 |
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2019 |
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2020-05-08T15:39:46Z |
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2020-05-08T15:39:46Z |
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STEFANI, Mariane Martins Araújo et al. Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil. Plos One, [San Francisco], v. 14, n. 1, p. 1-13, Jan. 2018. |
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https://www.arca.fiocruz.br/handle/icict/41169 |
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1932-6203 |
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10.1371/journal.pone.0209491 |
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STEFANI, Mariane Martins Araújo et al. Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil. Plos One, [San Francisco], v. 14, n. 1, p. 1-13, Jan. 2018. 1932-6203 10.1371/journal.pone.0209491 |
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