P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7818 |
Resumo: | Federal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil |
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Queiroz, ConceiçãoSilva, Tânia Maria CorreiaAlves, Venâncio Avancini FerreiraVilla, Luisa L.Costa, Maria CecíliaTravassos, Ana Gabriela ÁlvaresAraújo Filho, José BouzasStudart, EduardoCheto, TatianaFreitas, Luiz Antonio Rodrigues de2014-06-12T14:04:19Z2014-06-12T14:04:19Z2006QUEIROZ, C. et al. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathology Research Practice, v. 202, n. 2, p. 77-83, 2006.0344-0338https://www.arca.fiocruz.br/handle/icict/781810.1016/j.prp.2005.08.012engElsevierP16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFederal University São Paulo. Department of Pathology. Adolfo Lutz Institute. São Paulo, SP, BrasilVirology Department. Ludwig Institute for Cancer Research. Sao Paulo, SP, BrasilVirology Department. Ludwig Institute for Cancer Research. Sao Paulo, SP, BrasilFederal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, BrasilFederal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, BrasilFederal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilAn immunohistochemical analysis with monoclonal antibody p16INK4a was performed in formalin-fixed, paraffinembedded samples of 60 cases. The aim was to investigate in biopsies the expression of p16INK4a of normal uterine cervical tissue, pre-cancerous and cancerous lesions, and their relation with human papilloma virus (HPV) and HIV status. Three parameters were evaluated: percentage of p16INK4a positive cells, reaction intensity, and cell staining pattern. All of these parameters were statistically different when compared among different histological groups. However, logistic regression model showed that the reaction intensity was the best indicator of the expression of p16INK4a. This expression increases from normal to invasive squamous carcinoma. Sixty-six percent of the patients with CIN grade 1 (CIN1) expressed p16INK4a (all these cases were infected with high risk HPV). Our study supports the hypothesis that p16INK4a expression in pre-cancerous lesions and cancers can be used to identify HPV-transformed cells. Of great interest for routine diagnostic use is the fact that immunohistochemical testing for p16INK4a seems to be capable of identifying HPV-positive cells and potentially recognizing those lesions with an increased risk of progression to high-grade lesionsCervical neoplasiaDiagnostic markerp16INK4aHuman papillomavirus; Human immunodeficiency virusNeoplasia Intraepitelial Cervical/diagnósticoInibidor p16 de Quinase Ciclina-Dependente/metabolismoLesões Pré-Cancerosas/diagnósticoMarcadores Biológicos de Tumor/análiseNeoplasias do Colo do Útero/diagnósticoCarcinoma/diagnósticoNeoplasia Intraepitelial Cervical/complicaçõesFemininoColo do Útero/metabolismoInfecções por HIV/complicaçõesInfecções por HIV/diagnósticoHumanosImuno-HistoquímicaInfecções por Papillomavirus/complicaçõesInfecções por Papillomavirus/diagnósticoPrognósticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALQueiroz C P16INK4a expression....pdfQueiroz C P16INK4a expression....pdfapplication/pdf358121https://www.arca.fiocruz.br/bitstream/icict/7818/1/Queiroz%20C%20P16INK4a%20expression....pdfec8e0da03a8e7fff83c795995020a74fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7818/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTQueiroz C P16INK4a expression....pdf.txtQueiroz C P16INK4a expression....pdf.txtExtracted texttext/plain29584https://www.arca.fiocruz.br/bitstream/icict/7818/5/Queiroz%20C%20P16INK4a%20expression....pdf.txt76d998d46a476c82053b219bed9bf9e6MD55THUMBNAILQueiroz C P16INK4a expression....pdf.jpgQueiroz C P16INK4a expression....pdf.jpgGenerated Thumbnailimage/jpeg2110https://www.arca.fiocruz.br/bitstream/icict/7818/4/Queiroz%20C%20P16INK4a%20expression....pdf.jpgbb23e21af4a50f57e9f7a4c53cb994abMD54icict/78182023-03-15 14:33:23.657oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. |
| title |
P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. |
| spellingShingle |
P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Queiroz, Conceição Cervical neoplasia Diagnostic marker p16INK4a Human papillomavirus; Human immunodeficiency virus Neoplasia Intraepitelial Cervical/diagnóstico Inibidor p16 de Quinase Ciclina-Dependente/metabolismo Lesões Pré-Cancerosas/diagnóstico Marcadores Biológicos de Tumor/análise Neoplasias do Colo do Útero/diagnóstico Carcinoma/diagnóstico Neoplasia Intraepitelial Cervical/complicações Feminino Colo do Útero/metabolismo Infecções por HIV/complicações Infecções por HIV/diagnóstico Humanos Imuno-Histoquímica Infecções por Papillomavirus/complicações Infecções por Papillomavirus/diagnóstico Prognóstico |
| title_short |
P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. |
| title_full |
P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. |
| title_fullStr |
P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. |
| title_full_unstemmed |
P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. |
| title_sort |
P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. |
| author |
Queiroz, Conceição |
| author_facet |
Queiroz, Conceição Silva, Tânia Maria Correia Alves, Venâncio Avancini Ferreira Villa, Luisa L. Costa, Maria Cecília Travassos, Ana Gabriela Álvares Araújo Filho, José Bouzas Studart, Eduardo Cheto, Tatiana Freitas, Luiz Antonio Rodrigues de |
| author_role |
author |
| author2 |
Silva, Tânia Maria Correia Alves, Venâncio Avancini Ferreira Villa, Luisa L. Costa, Maria Cecília Travassos, Ana Gabriela Álvares Araújo Filho, José Bouzas Studart, Eduardo Cheto, Tatiana Freitas, Luiz Antonio Rodrigues de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Queiroz, Conceição Silva, Tânia Maria Correia Alves, Venâncio Avancini Ferreira Villa, Luisa L. Costa, Maria Cecília Travassos, Ana Gabriela Álvares Araújo Filho, José Bouzas Studart, Eduardo Cheto, Tatiana Freitas, Luiz Antonio Rodrigues de |
| dc.subject.en.pt_BR.fl_str_mv |
Cervical neoplasia Diagnostic marker p16INK4a Human papillomavirus; Human immunodeficiency virus |
| topic |
Cervical neoplasia Diagnostic marker p16INK4a Human papillomavirus; Human immunodeficiency virus Neoplasia Intraepitelial Cervical/diagnóstico Inibidor p16 de Quinase Ciclina-Dependente/metabolismo Lesões Pré-Cancerosas/diagnóstico Marcadores Biológicos de Tumor/análise Neoplasias do Colo do Útero/diagnóstico Carcinoma/diagnóstico Neoplasia Intraepitelial Cervical/complicações Feminino Colo do Útero/metabolismo Infecções por HIV/complicações Infecções por HIV/diagnóstico Humanos Imuno-Histoquímica Infecções por Papillomavirus/complicações Infecções por Papillomavirus/diagnóstico Prognóstico |
| dc.subject.decs.pt_BR.fl_str_mv |
Neoplasia Intraepitelial Cervical/diagnóstico Inibidor p16 de Quinase Ciclina-Dependente/metabolismo Lesões Pré-Cancerosas/diagnóstico Marcadores Biológicos de Tumor/análise Neoplasias do Colo do Útero/diagnóstico Carcinoma/diagnóstico Neoplasia Intraepitelial Cervical/complicações Feminino Colo do Útero/metabolismo Infecções por HIV/complicações Infecções por HIV/diagnóstico Humanos Imuno-Histoquímica Infecções por Papillomavirus/complicações Infecções por Papillomavirus/diagnóstico Prognóstico |
| description |
Federal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil |
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2006 |
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2006 |
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2014-06-12T14:04:19Z |
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2014-06-12T14:04:19Z |
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QUEIROZ, C. et al. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathology Research Practice, v. 202, n. 2, p. 77-83, 2006. |
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https://www.arca.fiocruz.br/handle/icict/7818 |
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0344-0338 |
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10.1016/j.prp.2005.08.012 |
| identifier_str_mv |
QUEIROZ, C. et al. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathology Research Practice, v. 202, n. 2, p. 77-83, 2006. 0344-0338 10.1016/j.prp.2005.08.012 |
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