Eosinophil granules function extracellularly as receptor-mediated secretory organelles
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/39853 |
Resumo: | Harvard Medical School. Department of Medicine. Boston, MA, USA. |
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Neves, Josiane S.Perez, Sandra A. C.Spencer, Lisa A.Melo, Rossana C. N.Reynolds, LaurenGhiran, IonitaMahmudi-Azerer, SalahaddinOdemuyiwa, Solomon O.Dvorak, Ann M.Moqbel, RedwanWeller, Peter F.2020-02-11T14:34:17Z2020-02-11T14:34:17Z2008NEVES, Josiane S. et al. Eosinophil granules function extracellularly as receptor-mediated secretory organelles . PNAS, v. 105, n. 47, p. 18478-18483, Nov. 2008.0027-8424https://www.arca.fiocruz.br/handle/icict/3985310.1073 pnas.08045471051091-6490engNational Academy of SciencesAlergiaIFN-yEotaxinaAllergySpecificEotaxinIFN-yEosinophil granules function extracellularly as receptor-mediated secretory organellesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHarvard Medical School. Department of Medicine. Boston, MA, USA.Harvard Medical School. Department of Medicine. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Harvard Medical School. Department of Medicine. Boston, MA, USA.Harvard Medical School. Department of Medicine. Boston, MA, USA / Universidade Federal de Juiz de Fora. Departamento de Biologia. Juiz de Fora, MG, Brasil / Harvard School of Medicine. Department of Pathology. Boston, MA, USA.Harvard Medical School. Department of Medicine. Boston, MA, USA.Harvard Medical School. Department of Medicine. Boston, MA, USA.University of Alberta. Department of Medicine. Pulmonary Research Group. Edmonton, Alberta, Canada.University of Alberta. Department of Medicine. Pulmonary Research Group. Edmonton, Alberta, Canada.Harvard School of Medicine. Department of Pathology. Boston, MA, USA.University of Alberta. Department of Medicine. Pulmonary Research Group. Edmonton, Alberta, Canada.Harvard Medical School. Department of Medicine. Boston, MA, USA.Intracellular granules in several types of leukocytes contain preformed proteins whose secretions contribute to immune and inflammatory functions of leukocytes, including eosinophils, cells notably associated with asthma, allergic inflammation, and helminthic infections. Cytokines and chemokines typically elicit extracellular secretion of granule proteins by engaging receptors expressed externally on the plasma membranes of cells, including eosinophils. Eosinophil granules, in addition to being intracellular organelles, are found as intact membrane-bound structures extracellularly in tissue sites of eosinophil-associated diseases. Neither the secretory capacities of cell-free eosinophil granules nor the presenceoffunctionalcytokineandchemokinereceptorsonmembranes of leukocyte granules have been recognized. Here, we show that granules of human eosinophils express membrane receptors for a cytokine, IFN , and G protein–coupled membrane receptors for a chemokine, eotaxin, and that these receptors function by activating signal-transducing pathways within granules to elicit secretion from within granules. Capacities of intracellular granule organelles to function autonomously outside of eosinophils as independent, ligand-responsive, secretion-competent structures constitute a novel postcytolytic mechanism for regulated secretion of eosinophil granule proteins that may contribute to eosinophil-mediated inflammation and immunomodulation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39853/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSandraAC_`Perez_etal_IOC_2008.pdfSandraAC_`Perez_etal_IOC_2008.pdfapplication/pdf769440https://www.arca.fiocruz.br/bitstream/icict/39853/2/SandraAC_%60Perez_etal_IOC_2008.pdf3f60867c1e1cde4d8824b1125d216077MD52TEXTSandraAC_`Perez_etal_IOC_2008.pdf.txtSandraAC_`Perez_etal_IOC_2008.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Eosinophil granules function extracellularly as receptor-mediated secretory organelles |
| title |
Eosinophil granules function extracellularly as receptor-mediated secretory organelles |
| spellingShingle |
Eosinophil granules function extracellularly as receptor-mediated secretory organelles Neves, Josiane S. Alergia IFN-y Eotaxina Allergy Specific Eotaxin IFN-y |
| title_short |
Eosinophil granules function extracellularly as receptor-mediated secretory organelles |
| title_full |
Eosinophil granules function extracellularly as receptor-mediated secretory organelles |
| title_fullStr |
Eosinophil granules function extracellularly as receptor-mediated secretory organelles |
| title_full_unstemmed |
Eosinophil granules function extracellularly as receptor-mediated secretory organelles |
| title_sort |
Eosinophil granules function extracellularly as receptor-mediated secretory organelles |
| author |
Neves, Josiane S. |
| author_facet |
Neves, Josiane S. Perez, Sandra A. C. Spencer, Lisa A. Melo, Rossana C. N. Reynolds, Lauren Ghiran, Ionita Mahmudi-Azerer, Salahaddin Odemuyiwa, Solomon O. Dvorak, Ann M. Moqbel, Redwan Weller, Peter F. |
| author_role |
author |
| author2 |
Perez, Sandra A. C. Spencer, Lisa A. Melo, Rossana C. N. Reynolds, Lauren Ghiran, Ionita Mahmudi-Azerer, Salahaddin Odemuyiwa, Solomon O. Dvorak, Ann M. Moqbel, Redwan Weller, Peter F. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Neves, Josiane S. Perez, Sandra A. C. Spencer, Lisa A. Melo, Rossana C. N. Reynolds, Lauren Ghiran, Ionita Mahmudi-Azerer, Salahaddin Odemuyiwa, Solomon O. Dvorak, Ann M. Moqbel, Redwan Weller, Peter F. |
| dc.subject.other.pt_BR.fl_str_mv |
Alergia IFN-y Eotaxina |
| topic |
Alergia IFN-y Eotaxina Allergy Specific Eotaxin IFN-y |
| dc.subject.en.pt_BR.fl_str_mv |
Allergy Specific Eotaxin IFN-y |
| description |
Harvard Medical School. Department of Medicine. Boston, MA, USA. |
| publishDate |
2008 |
| dc.date.issued.fl_str_mv |
2008 |
| dc.date.accessioned.fl_str_mv |
2020-02-11T14:34:17Z |
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2020-02-11T14:34:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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NEVES, Josiane S. et al. Eosinophil granules function extracellularly as receptor-mediated secretory organelles . PNAS, v. 105, n. 47, p. 18478-18483, Nov. 2008. |
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https://www.arca.fiocruz.br/handle/icict/39853 |
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0027-8424 |
| dc.identifier.doi.none.fl_str_mv |
10.1073 pnas.0804547105 |
| dc.identifier.eissn.none.fl_str_mv |
1091-6490 |
| identifier_str_mv |
NEVES, Josiane S. et al. Eosinophil granules function extracellularly as receptor-mediated secretory organelles . PNAS, v. 105, n. 47, p. 18478-18483, Nov. 2008. 0027-8424 10.1073 pnas.0804547105 1091-6490 |
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National Academy of Sciences |
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National Academy of Sciences |
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