Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31930 |
Resumo: | Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Siqueira, André M.Lacerda, Marcus V. G.Magalhães, Belisa M. L.Mourão, Maria P. G.Melo, Gisely C.Alexandre, Márcia A. A.Alecrim, Maria G. C.Kochar, DhanpatKochar, SanjayKochar, AbhishekNayak, KailashPortillo, Hernando delGuinovart, CaterinaAlonso, PedroBassat, Quique2019-02-28T14:41:09Z2019-02-28T14:41:09Z2015SIQUEIRA, André M. et al. Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India. BMC Medicine, v. 13, n. 57, p. 1-14, 2015.1741-7015https://www.arca.fiocruz.br/handle/icict/3193010.1186/s12916-015-0302-y1741-7015engBMCCharacterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and Indiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas e Maria Deane. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil.Sardar Patel Medical College. Bikaner, Rajasthan, India / PBM Hospital. Bikaner, Rajasthan, India.Sardar Patel Medical College. Bikaner, Rajasthan, India / PBM Hospital. Bikaner, Rajasthan, India.Sardar Patel Medical College. Bikaner, Rajasthan, India / PBM Hospital. Bikaner, Rajasthan, India.Sardar Patel Medical College. Bikaner, Rajasthan, India / PBM Hospital. Bikaner, Rajasthan, India.Universitat de Barcelona. Hospital Clínic. Barcelona, Spain / Barcelona Institute for Global Health. Barcelona, Spain / Institució Catalana de Recerca i Estudis Avançats. Barcelona, Spain.Universitat de Barcelona. Hospital Clínic. Barcelona, Spain / Barcelona Institute for Global Health. Barcelona, Spain / Centro de Investigação em Saúde de Manhiça. Maputo, Mozambique.Universitat de Barcelona. Hospital Clínic. Barcelona, Spain / Barcelona Institute for Global Health. Barcelona, Spain / Centro de Investigação em Saúde de Manhiça. Maputo, Mozambique.Universitat de Barcelona. Hospital Clínic. Barcelona, Spain / Barcelona Institute for Global Health. Barcelona, Spain / Centro de Investigação em Saúde de Manhiça. Maputo, Mozambique.Background: The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complications. Endemic areas exhibit wide variations regarding severe disease frequency. This study, conducted simultaneously in Brazil and India, constitutes, to our knowledge, the first multisite study focused on clinical characterization of P. vivax severe disease. Methods: Patients admitted with P. vivax mono-infection at reference centers in Manaus (Amazon - Brazil) and Bikaner (Rajasthan - India), where P. vivax predominates, were submitted to standard thorough clinical and laboratory evaluations in order to characterize clinical manifestations and identify concurrent co-morbidities. Results: In total, 778 patients (88.0% above 12 years old) were hospitalized at clinical discretion with PCR-confirmed P. vivax mono-infection (316 in Manaus and 462 in Bikaner), of which 197 (25.3%) presented at least one severity criterion as defined by the World Health Organization (2010). Hyperlactatemia, respiratory distress, hypoglycemia, and disseminated intravascular coagulation were more frequent in Manaus. Noteworthy, pregnancy status was associated as a risk factor for severe disease (OR = 2.03; 95% CI = 1.2-3.4; P = 0.007). The overall case fatality rate was 0.3/1,000 cases in Manaus and 6.1/1,000 cases in Bikaner, with all deaths occurring among patients fulfilling at least one severity criterion. Within this subgroup, case fatality rates increased respectively to 7.5% in Manaus and 4.4% in Bikaner. Conclusion: P. vivax-associated severity is not negligible, and although lethality observed for complicated cases was similar, the overall fatality rate was about 20-fold higher in India compared to Brazil, highlighting the variability observed in different settings. Our observations highlight that pregnant women and patients with co-morbidities need special attention when infected by this parasite due to higher risk of complicationsPlasmodium vivaxSevere malariaClinical complicationsIndiaBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31930/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Siqueira_André_etal_INI_2015.pdfve_Siqueira_André_etal_INI_2015.pdfapplication/pdf1727278https://www.arca.fiocruz.br/bitstream/icict/31930/2/ve_Siqueira_Andr%c3%a9_etal_INI_2015.pdfc941398efd2f5b687d72efd99d0266e6MD52TEXTve_Siqueira_André_etal_INI_2015.pdf.txtve_Siqueira_André_etal_INI_2015.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India |
| title |
Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India |
| spellingShingle |
Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India Siqueira, André M. Plasmodium vivax Severe malaria Clinical complications India Brazil |
| title_short |
Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India |
| title_full |
Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India |
| title_fullStr |
Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India |
| title_full_unstemmed |
Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India |
| title_sort |
Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India |
| author |
Siqueira, André M. |
| author_facet |
Siqueira, André M. Lacerda, Marcus V. G. Magalhães, Belisa M. L. Mourão, Maria P. G. Melo, Gisely C. Alexandre, Márcia A. A. Alecrim, Maria G. C. Kochar, Dhanpat Kochar, Sanjay Kochar, Abhishek Nayak, Kailash Portillo, Hernando del Guinovart, Caterina Alonso, Pedro Bassat, Quique |
| author_role |
author |
| author2 |
Lacerda, Marcus V. G. Magalhães, Belisa M. L. Mourão, Maria P. G. Melo, Gisely C. Alexandre, Márcia A. A. Alecrim, Maria G. C. Kochar, Dhanpat Kochar, Sanjay Kochar, Abhishek Nayak, Kailash Portillo, Hernando del Guinovart, Caterina Alonso, Pedro Bassat, Quique |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Siqueira, André M. Lacerda, Marcus V. G. Magalhães, Belisa M. L. Mourão, Maria P. G. Melo, Gisely C. Alexandre, Márcia A. A. Alecrim, Maria G. C. Kochar, Dhanpat Kochar, Sanjay Kochar, Abhishek Nayak, Kailash Portillo, Hernando del Guinovart, Caterina Alonso, Pedro Bassat, Quique |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium vivax Severe malaria Clinical complications India Brazil |
| topic |
Plasmodium vivax Severe malaria Clinical complications India Brazil |
| description |
Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malaria. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2015 |
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2015 |
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2019-02-28T14:41:09Z |
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2019-02-28T14:41:09Z |
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SIQUEIRA, André M. et al. Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India. BMC Medicine, v. 13, n. 57, p. 1-14, 2015. |
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https://www.arca.fiocruz.br/handle/icict/31930 |
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1741-7015 |
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10.1186/s12916-015-0302-y |
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1741-7015 |
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SIQUEIRA, André M. et al. Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India. BMC Medicine, v. 13, n. 57, p. 1-14, 2015. 1741-7015 10.1186/s12916-015-0302-y |
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