Neutrophils in leprosy

Schmitz, Veronica; Tavares, Isabella Forasteiro; Pignataro, Patricia; Machado, Alice de Miranda; Pacheco, Fabiana dos Santos; Santos, Jéssica Brandão dos; Silva, Camila Oliveira da; Sarno, Euzenir Nunes

Neutrophils in leprosy

Detalhes bibliográficos
Autor(a) principal:	Schmitz, Veronica
Data de Publicação:	2019
Outros Autores:	Tavares, Isabella Forasteiro, Pignataro, Patricia, Machado, Alice de Miranda, Pacheco, Fabiana dos Santos, Santos, Jéssica Brandão dos, Silva, Camila Oliveira da, Sarno, Euzenir Nunes
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/34034
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.

Metadados do item

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spelling	Schmitz, VeronicaTavares, Isabella ForasteiroPignataro, PatriciaMachado, Alice de MirandaPacheco, Fabiana dos SantosSantos, Jéssica Brandão dosSilva, Camila Oliveira daSarno, Euzenir Nunes2019-07-12T17:30:33Z2019-07-12T17:30:33Z2019SCHMITZ, Veronica et al. Neutrophils in Leprosy. Frontiers in Immunology, v. 10, p. 1-10, Mar. 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/3403410.3389/fimmu.2019.00495engFrontiers MediaHanseníaseMycobacterium lepraeInflamaçãoNeutrófilosEritema nodoso hansênicoLeprosyMycobacterium lepraeErythema nodosum leprosumInflammationNeutrophilsNeutrophils in leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.LeprosyisaninfectiousdiseasecausedbytheintracellularbacillusMycobacteriumleprae that mainly affects the skin and peripheral nerves. One of the most intriguing aspects of leprosy is the diversity of its clinical forms. Paucibacillary patients are characterized as having less than ﬁve skin lesions and rare bacilli while the lesions in multibacillary patients are disseminated with voluminous bacilli. The chronic course of leprosy is often interrupted by acute episodes of an inﬂammatory immunological response classiﬁed as either reversal reaction or erythema nodosum leprosum (ENL). Although ENL is considered a neutrophilic immune-complex mediated condition, little is known about the direct role of neutrophils in ENL and leprosy disease overall. Recent studies have shown a renewed interest in neutrophilic biology. One of the most interesting recent discoveries was that the neutrophilic population is not homogeneous. Neutrophilic polarization leads to divergent phenotypes (e.g., a pro- and antitumor proﬁle) that are dynamic subpopulations with distinct phenotypical and functional abilities. Moreover, there is emerging evidence indicating that neutrophils expressing CD64 favor systemic inﬂammation during ENL. In the present review, neutrophilic involvement in leprosy is discussed with a particular focus on ENL and the potential of neutrophils as clinical biomarkers and therapeutic targets.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34034/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEuzenirNSarno_IsabelaTavares_etal_IOC_2019.pdfEuzenirNSarno_IsabelaTavares_etal_IOC_2019.pdfapplication/pdf6274646https://www.arca.fiocruz.br/bitstream/icict/34034/2/EuzenirNSarno_IsabelaTavares_etal_IOC_2019.pdf96dca7989777c0bb3e19632004332a98MD52TEXTEuzenirNSarno_IsabelaTavares_etal_IOC_2019.pdf.txtEuzenirNSarno_IsabelaTavares_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Neutrophils in leprosy
title	Neutrophils in leprosy
spellingShingle	Neutrophils in leprosy Schmitz, Veronica Hanseníase Mycobacterium leprae Inflamação Neutrófilos Eritema nodoso hansênico Leprosy Mycobacterium leprae Erythema nodosum leprosum Inflammation Neutrophils
title_short	Neutrophils in leprosy
title_full	Neutrophils in leprosy
title_fullStr	Neutrophils in leprosy
title_full_unstemmed	Neutrophils in leprosy
title_sort	Neutrophils in leprosy
author	Schmitz, Veronica
author_facet	Schmitz, Veronica Tavares, Isabella Forasteiro Pignataro, Patricia Machado, Alice de Miranda Pacheco, Fabiana dos Santos Santos, Jéssica Brandão dos Silva, Camila Oliveira da Sarno, Euzenir Nunes
author_role	author
author2	Tavares, Isabella Forasteiro Pignataro, Patricia Machado, Alice de Miranda Pacheco, Fabiana dos Santos Santos, Jéssica Brandão dos Silva, Camila Oliveira da Sarno, Euzenir Nunes
author2_role	author author author author author author author
dc.contributor.author.fl_str_mv	Schmitz, Veronica Tavares, Isabella Forasteiro Pignataro, Patricia Machado, Alice de Miranda Pacheco, Fabiana dos Santos Santos, Jéssica Brandão dos Silva, Camila Oliveira da Sarno, Euzenir Nunes
dc.subject.other.pt_BR.fl_str_mv	Hanseníase Mycobacterium leprae Inflamação Neutrófilos Eritema nodoso hansênico
topic	Hanseníase Mycobacterium leprae Inflamação Neutrófilos Eritema nodoso hansênico Leprosy Mycobacterium leprae Erythema nodosum leprosum Inflammation Neutrophils
dc.subject.en.pt_BR.fl_str_mv	Leprosy Mycobacterium leprae Erythema nodosum leprosum Inflammation Neutrophils
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
publishDate	2019
dc.date.accessioned.fl_str_mv	2019-07-12T17:30:33Z
dc.date.available.fl_str_mv	2019-07-12T17:30:33Z
dc.date.issued.fl_str_mv	2019
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SCHMITZ, Veronica et al. Neutrophils in Leprosy. Frontiers in Immunology, v. 10, p. 1-10, Mar. 2019.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/34034
dc.identifier.issn.pt_BR.fl_str_mv	1664-3224
dc.identifier.doi.none.fl_str_mv	10.3389/fimmu.2019.00495
identifier_str_mv	SCHMITZ, Veronica et al. Neutrophils in Leprosy. Frontiers in Immunology, v. 10, p. 1-10, Mar. 2019. 1664-3224 10.3389/fimmu.2019.00495
url	https://www.arca.fiocruz.br/handle/icict/34034
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Frontiers Media
publisher.none.fl_str_mv	Frontiers Media
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Neutrophils in leprosy

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