Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16512 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. |
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Schmitz, VeronicaPrata, Rhana Berto da SilvaBarbosa, Mayara Garcia de MattosMendes, Mayara AbudBrandão, Sheila SantosAmadeu, Thaís PortoRodrigues, Luciana SilvaFerreira, HelenCosta, Fabrício da Mota RamalhoSantos, Jessica Brandão dosPacheco, Fabiana dos SantosMachado, Alice de MirandaNery, José Augusto da CostaHacker, Mariana de AndreaSales, Anna MariaPinheiro, Roberta OlmoSarno, Euzenir Nunes2016-12-13T11:16:42Z2016-12-13T11:16:42Z2016SCHMITZ, Veronica; et al. Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum. PLoS Negl Trop Dis, v.10, n.8, e0004955, 18p, Aug. 2016.1935-2727https://www.arca.fiocruz.br/handle/icict/1651210.1371/journal.pntd.00049551935-2735engPublic Library of ScienceEritema nodoso LeprosumHanseníaseEstado inflamatório sistêmicoReceptores de IgGNeutrófilosErythema Nodosum Leprosum (ENL)LeprosySystemic Inflammatory StatusCD64NeutrophilsExpression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Erythema Nodosum Leprosum (ENL) is an immune reaction in leprosy that aggravates the patient´s clinical condition. ENL presents systemic symptoms of an acute infectious syndrome with high leukocytosis and intense malaise clinically similar to sepsis. The treatment of ENL patients requires immunosuppression and thus needs to be early and efficient to prevent both disabilities and permanent nerve damage. Some patients experience multiple episodes of ENL and prolonged use of immunosuppressive drugs may lead to serious adverse effects. Thalidomide treatment is extremely effective at ameliorating ENL symptoms. Several mechanisms have been proposed to explain the efficacy of thalidomide in ENL, including the inhibition of TNF production. Given its teratogenicity, thalidomide is prohibitive for women of childbearing age. A rational search for molecular targets during ENL episodes is essential to better understand the disease mechanisms involved, which may also lead to the discovery of new drugs and diagnostic tests. Previous studies have demonstrated that IFN-γ and GM-CSF, involved in the induction of CD64 expression, increase during ENL. The aim of the present study was to investigate CD64 expression during ENL and whether thalidomide treatment modulated its expression. Leprosy patients were allocated to one of five groups: (1) Lepromatous leprosy, (2) Borderline leprosy, (3) Reversal reaction, (4) ENL, and (5) ENL 7 days after thalidomide treatment. The present study demonstrated that CD64 mRNA and protein were expressed in ENL lesions and that thalidomide treatment reduced CD64 expression and neutrophil infiltrates-a hallmark of ENL. We also showed that ENL blood neutrophils exclusively expressed CD64 on the cell surface and that thalidomide diminished overall expression. Patient classification based on clinical symptoms found that severe ENL presented high levels of neutrophil CD64. Collectively, these data revealed that ENL neutrophils express CD64, presumably contributing to the immunopathogenesis of the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16512/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALrhana_prata_etal_IOC_2016.pdfrhana_prata_etal_IOC_2016.pdfapplication/pdf9876996https://www.arca.fiocruz.br/bitstream/icict/16512/2/rhana_prata_etal_IOC_2016.pdf8da2d12607fbdb020d79874481199773MD52TEXTrhana_prata_etal_IOC_2016.pdf.txtrhana_prata_etal_IOC_2016.pdf.txtExtracted texttext/plain62283https://www.arca.fiocruz.br/bitstream/icict/16512/3/rhana_prata_etal_IOC_2016.pdf.txtbcf5304ad00f33cf3348e786ac4542afMD53icict/165122022-06-24 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| dc.title.pt_BR.fl_str_mv |
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum |
| title |
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum |
| spellingShingle |
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum Schmitz, Veronica Eritema nodoso Leprosum Hanseníase Estado inflamatório sistêmico Receptores de IgG Neutrófilos Erythema Nodosum Leprosum (ENL) Leprosy Systemic Inflammatory Status CD64 Neutrophils |
| title_short |
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum |
| title_full |
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum |
| title_fullStr |
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum |
| title_full_unstemmed |
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum |
| title_sort |
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum |
| author |
Schmitz, Veronica |
| author_facet |
Schmitz, Veronica Prata, Rhana Berto da Silva Barbosa, Mayara Garcia de Mattos Mendes, Mayara Abud Brandão, Sheila Santos Amadeu, Thaís Porto Rodrigues, Luciana Silva Ferreira, Helen Costa, Fabrício da Mota Ramalho Santos, Jessica Brandão dos Pacheco, Fabiana dos Santos Machado, Alice de Miranda Nery, José Augusto da Costa Hacker, Mariana de Andrea Sales, Anna Maria Pinheiro, Roberta Olmo Sarno, Euzenir Nunes |
| author_role |
author |
| author2 |
Prata, Rhana Berto da Silva Barbosa, Mayara Garcia de Mattos Mendes, Mayara Abud Brandão, Sheila Santos Amadeu, Thaís Porto Rodrigues, Luciana Silva Ferreira, Helen Costa, Fabrício da Mota Ramalho Santos, Jessica Brandão dos Pacheco, Fabiana dos Santos Machado, Alice de Miranda Nery, José Augusto da Costa Hacker, Mariana de Andrea Sales, Anna Maria Pinheiro, Roberta Olmo Sarno, Euzenir Nunes |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Schmitz, Veronica Prata, Rhana Berto da Silva Barbosa, Mayara Garcia de Mattos Mendes, Mayara Abud Brandão, Sheila Santos Amadeu, Thaís Porto Rodrigues, Luciana Silva Ferreira, Helen Costa, Fabrício da Mota Ramalho Santos, Jessica Brandão dos Pacheco, Fabiana dos Santos Machado, Alice de Miranda Nery, José Augusto da Costa Hacker, Mariana de Andrea Sales, Anna Maria Pinheiro, Roberta Olmo Sarno, Euzenir Nunes |
| dc.subject.other.pt_BR.fl_str_mv |
Eritema nodoso Leprosum Hanseníase Estado inflamatório sistêmico Receptores de IgG Neutrófilos |
| topic |
Eritema nodoso Leprosum Hanseníase Estado inflamatório sistêmico Receptores de IgG Neutrófilos Erythema Nodosum Leprosum (ENL) Leprosy Systemic Inflammatory Status CD64 Neutrophils |
| dc.subject.en.pt_BR.fl_str_mv |
Erythema Nodosum Leprosum (ENL) Leprosy Systemic Inflammatory Status CD64 Neutrophils |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. |
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2016 |
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2016-12-13T11:16:42Z |
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2016-12-13T11:16:42Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SCHMITZ, Veronica; et al. Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum. PLoS Negl Trop Dis, v.10, n.8, e0004955, 18p, Aug. 2016. |
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1935-2727 |
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10.1371/journal.pntd.0004955 |
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1935-2735 |
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SCHMITZ, Veronica; et al. Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum. PLoS Negl Trop Dis, v.10, n.8, e0004955, 18p, Aug. 2016. 1935-2727 10.1371/journal.pntd.0004955 1935-2735 |
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