Is there a place for cellular therapy in depression?

Detalhes bibliográficos
Autor(a) principal: Lima, Pedro Antônio Schmidt do Prado
Data de Publicação: 2021
Outros Autores: Costa-Ferro, Zaquer Suzana Munhoz, Souza, Bruno Solano de Freitas, Cruz, Ivana Beatrice Manica da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49872
Resumo: Conselho Nacional de Desenvolvimento Cientifico - CNPq.
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spelling Lima, Pedro Antônio Schmidt do PradoCosta-Ferro, Zaquer Suzana MunhozSouza, Bruno Solano de FreitasCruz, Ivana Beatrice Manica da2021-11-18T18:11:09Z2021-11-18T18:11:09Z2021LIMA, Pedro Antônio Schmidt do Prado et al. Is there a place for cellular therapy in depression? World Journal of Psychiatry, v. 11, n. 9, p. 553-567, 2021.2220-3206https://www.arca.fiocruz.br/handle/icict/4987210.5498/wjp.v11.i9.553Conselho Nacional de Desenvolvimento Cientifico - CNPq.Pontifical Catholic University of Rio Grande do Sul. Brain Institute of Rio Grande do Sul. Porto Alegre, RS, Brasil.Pontifical Catholic University of Rio Grande do Sul. Brain Institute of Rio Grande do Sul. Porto Alegre, RS, Brasil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia de Tecidos e Imunofarmacologia. Salvador, BA, Brasil.Federal University of Santa Maria. Lab Health Sciences Center. Santa Maria, RS, Brazil.Although efforts have been made to improve the pharmacological treatment of depression, approximately one-third of patients with depression do not respond to conventional therapy using antidepressants. Other potential non-pharmacological therapies have been studied in the last years, including the use of mesenchymal stem cell therapies to treat depression. These therapies are reviewed here since it is clinically relevant to develop innovative therapeutics to treat psychiatric patients. Experimental data corroborate that mesenchymal stem cell therapy could be considered a potential treatment for depression based on its antiinflammatory and neurotrophic properties. However, some clinical trials involving treatment of depression with stem cells are in progress, but with no published results. These studies and other future clinical investigations will be crucial to define how much mesenchymal stem cells can effectively be used in psychiatric clinics as a strategy for supporting depression treatment.engBaishideng Publishing GroupTranstornos de HumorTransplante de células-troncoTransplante de células-tronco mesenquimais;InflamaçãoImunomodulaçãoDepressãoMood disorders;Stem cells transplant;Mesenchymal stem-cells transplant;Inflammation; Immunomodulation; DepressionIs there a place for cellular therapy in depression?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49872/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALLima, Pedro Antonio Schmidt do Prado Is there ....pdfLima, Pedro Antonio Schmidt do Prado Is there ....pdfapplication/pdf1024369https://www.arca.fiocruz.br/bitstream/icict/49872/2/Lima%2c%20Pedro%20Antonio%20Schmidt%20do%20Prado%20Is%20there%20....pdfca2f60f0c75d2cb9ae07e2e38d518119MD52icict/498722023-03-15 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dc.title.pt_BR.fl_str_mv Is there a place for cellular therapy in depression?
title Is there a place for cellular therapy in depression?
spellingShingle Is there a place for cellular therapy in depression?
Lima, Pedro Antônio Schmidt do Prado
Transtornos de Humor
Transplante de células-tronco
Transplante de células-tronco mesenquimais;
Inflamação
Imunomodulação
Depressão
Mood disorders;
Stem cells transplant;
Mesenchymal stem-cells transplant;
Inflammation; Immunomodulation; Depression
title_short Is there a place for cellular therapy in depression?
title_full Is there a place for cellular therapy in depression?
title_fullStr Is there a place for cellular therapy in depression?
title_full_unstemmed Is there a place for cellular therapy in depression?
title_sort Is there a place for cellular therapy in depression?
author Lima, Pedro Antônio Schmidt do Prado
author_facet Lima, Pedro Antônio Schmidt do Prado
Costa-Ferro, Zaquer Suzana Munhoz
Souza, Bruno Solano de Freitas
Cruz, Ivana Beatrice Manica da
author_role author
author2 Costa-Ferro, Zaquer Suzana Munhoz
Souza, Bruno Solano de Freitas
Cruz, Ivana Beatrice Manica da
author2_role author
author
author
dc.contributor.author.fl_str_mv Lima, Pedro Antônio Schmidt do Prado
Costa-Ferro, Zaquer Suzana Munhoz
Souza, Bruno Solano de Freitas
Cruz, Ivana Beatrice Manica da
dc.subject.other.pt_BR.fl_str_mv Transtornos de Humor
Transplante de células-tronco
Transplante de células-tronco mesenquimais;
Inflamação
Imunomodulação
Depressão
topic Transtornos de Humor
Transplante de células-tronco
Transplante de células-tronco mesenquimais;
Inflamação
Imunomodulação
Depressão
Mood disorders;
Stem cells transplant;
Mesenchymal stem-cells transplant;
Inflammation; Immunomodulation; Depression
dc.subject.en.pt_BR.fl_str_mv Mood disorders;
Stem cells transplant;
Mesenchymal stem-cells transplant;
Inflammation; Immunomodulation; Depression
description Conselho Nacional de Desenvolvimento Cientifico - CNPq.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-18T18:11:09Z
dc.date.available.fl_str_mv 2021-11-18T18:11:09Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Pedro Antônio Schmidt do Prado et al. Is there a place for cellular therapy in depression? World Journal of Psychiatry, v. 11, n. 9, p. 553-567, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49872
dc.identifier.issn.pt_BR.fl_str_mv 2220-3206
dc.identifier.doi.none.fl_str_mv 10.5498/wjp.v11.i9.553
identifier_str_mv LIMA, Pedro Antônio Schmidt do Prado et al. Is there a place for cellular therapy in depression? World Journal of Psychiatry, v. 11, n. 9, p. 553-567, 2021.
2220-3206
10.5498/wjp.v11.i9.553
url https://www.arca.fiocruz.br/handle/icict/49872
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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