Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14252 |
Resumo: | Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil |
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Silva, Thanany Brasil daMenezes, Leociley Rocha AlencarSampaio, Marília Fernanda ChavesMeira, Cássio SantanaGuimarães, Elisalva TeixeiraSoares, Milena Botelho PereiraPrata, Ana Paula do NascimentoNogueira, Paulo Cesar de LimaCosta, Emmanoel Vilaça2016-05-11T16:37:02Z2016-05-11T16:37:02Z2013SILVA, T. B. et al. Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae). Natural Product Communications, v. 8, n. 3, p. 403-406, 2013.1934-578Xhttps://www.arca.fiocruz.br/handle/icict/14252engNatural Product CommunicationsChemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilUniversidade Federal de Sergipe. Departamento de Biologia. São Cristóvão, SE, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, BrasilEssential oils from leaves of Xylopia frutescens (XFMJ) and two specimens of Xylopia laevigata (XLMC and XLSI) were obtained by hydrodistillation using a Clevenger-type apparatus, and analyzed by GC-MS and GC-FID. Sesquiterpenes dominated the essential oils. The main constituents of XFMJ were (E)-caryophyllene (24.8%), bicyclogermacrene (20.8%), germacrene D (17.0%), -elemene (7.9%), and (E)--ocimene (6.8%). XLMC contained significant quantities of germacrene D (18.9%), bicyclogermacrene (18.4%), -elemene (9.5%), -selinene (9.2%), (E)-caryophyllene (8.5%), germacrene B (5.7%) and -muurolene (5.7%), while germacrene D (27.0%), bicyclogermacrene (12.8%), (E)-caryophyllene (8.6%), -muurolene (8.6%), -cadinene (6.8%), and germacrene B (6.0%) were the main components of XLSI. The essential oils had trypanocidal activity against the Y strain of Trypanosoma cruzi, with IC50 values lower than 30 μg.mL-1 and 15 μg.mL-1 against epimastigote and trypomastigote forms of T. cruzi, respectively, and were also able to reduce the percentage in vitro of T. cruzi-infected macrophages and the intracellular number of amastigotes at concentrations that were non-cytotoxic to macrophagesXylopia frutescensXylopia laevigataEssential oilTrypanocidal activityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14252/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva TB Chemical composition....pdfSilva TB Chemical 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| dc.title.pt_BR.fl_str_mv |
Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae) |
| title |
Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae) |
| spellingShingle |
Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae) Silva, Thanany Brasil da Xylopia frutescens Xylopia laevigata Essential oil Trypanocidal activity |
| title_short |
Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae) |
| title_full |
Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae) |
| title_fullStr |
Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae) |
| title_full_unstemmed |
Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae) |
| title_sort |
Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae) |
| author |
Silva, Thanany Brasil da |
| author_facet |
Silva, Thanany Brasil da Menezes, Leociley Rocha Alencar Sampaio, Marília Fernanda Chaves Meira, Cássio Santana Guimarães, Elisalva Teixeira Soares, Milena Botelho Pereira Prata, Ana Paula do Nascimento Nogueira, Paulo Cesar de Lima Costa, Emmanoel Vilaça |
| author_role |
author |
| author2 |
Menezes, Leociley Rocha Alencar Sampaio, Marília Fernanda Chaves Meira, Cássio Santana Guimarães, Elisalva Teixeira Soares, Milena Botelho Pereira Prata, Ana Paula do Nascimento Nogueira, Paulo Cesar de Lima Costa, Emmanoel Vilaça |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Thanany Brasil da Menezes, Leociley Rocha Alencar Sampaio, Marília Fernanda Chaves Meira, Cássio Santana Guimarães, Elisalva Teixeira Soares, Milena Botelho Pereira Prata, Ana Paula do Nascimento Nogueira, Paulo Cesar de Lima Costa, Emmanoel Vilaça |
| dc.subject.en.pt_BR.fl_str_mv |
Xylopia frutescens Xylopia laevigata Essential oil Trypanocidal activity |
| topic |
Xylopia frutescens Xylopia laevigata Essential oil Trypanocidal activity |
| description |
Universidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, Brasil |
| publishDate |
2013 |
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2013 |
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2016-05-11T16:37:02Z |
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2016-05-11T16:37:02Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SILVA, T. B. et al. Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae). Natural Product Communications, v. 8, n. 3, p. 403-406, 2013. |
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https://www.arca.fiocruz.br/handle/icict/14252 |
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1934-578X |
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SILVA, T. B. et al. Chemical Composition and Anti-Trypanosoma cruzi Activity of cruzi Activity of Essential Oils Obtained from Leaves of Xylopia frutescens and X. laevigata (Annonaceae). Natural Product Communications, v. 8, n. 3, p. 403-406, 2013. 1934-578X |
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Natural Product Communications |
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Natural Product Communications |
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