Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects

Detalhes bibliográficos
Autor(a) principal: Almeida, Fausto
Data de Publicação: 2017
Outros Autores: Wolf, Julie M, da Silva, Thiago Aparecido, DeLeon-Rodriguez, Carlos M, Rezende, Caroline Patini, Pessoni, André Moreira, Fernandes, Fabrício Freitas, Silva-Rocha, Rafael, Martinez, Roberto, Rodrigues, Marcio Lourenço, Roque-Barreira, Maria Cristina, Casadevall, Arturo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27670
Resumo: University of Sao Paulo. Ribeirao Preto Medical School. Department of Biochemistry and Immunology. Ribeirao Preto, SP, Brasil.
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spelling Almeida, FaustoWolf, Julie Mda Silva, Thiago AparecidoDeLeon-Rodriguez, Carlos MRezende, Caroline PatiniPessoni, André MoreiraFernandes, Fabrício FreitasSilva-Rocha, RafaelMartinez, RobertoRodrigues, Marcio LourençoRoque-Barreira, Maria CristinaCasadevall, Arturo2018-07-26T13:39:30Z2018-07-26T13:39:30Z2017ALMEIDA, F. et al. Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects. Nature Communications, v. 8, p. 1968, 2017.2041-1723https://www.arca.fiocruz.br/handle/icict/2767010.1038/s41467-017-02126-7engNaturegalectinacriptococcoseGalectin-3 impacts Cryptococcus neoformans infection through direct antifungal effectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Sao Paulo. Ribeirao Preto Medical School. Department of Biochemistry and Immunology. Ribeirao Preto, SP, Brasil.Yeshiva University. Albert Einstein College of Medicine. Department of Microbiology and Immunology. New York, NY, EUA.University of Sao Paulo. Ribeirao Preto Medical School. Department of Cellular and Molecular Biology. Ribeirao Preto, SP, Brasil.Yeshiva University. Albert Einstein College of Medicine. Department of Microbiology and Immunology. New York, NY, EUA.University of Sao Paulo. Ribeirao Preto Medical School. Department of Biochemistry and Immunology. Ribeirao Preto, SP, Brasil.University of Sao Paulo. Ribeirao Preto Medical School. Department of Biochemistry and Immunology. Ribeirao Preto, SP, Brasil.University of Sao Paulo. Ribeirao Preto Medical School. Department of Cellular and Molecular Biology. Ribeirao Preto, SP, Brasil.University of Sao Paulo. Ribeirao Preto Medical School. Department of Cellular and Molecular Biology. Ribeirao Preto, SP, Brasil.University of Sao Paulo. Ribeirao Preto Medical School . Department of Internal Medicine. Ribeirao Preto, SP, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Rio de Janeiro, RJ, Brasil.University of Sao Paulo. Ribeirao Preto Medical School. Department of Cellular and Molecular Biology. Ribeirao Preto, SP, Brasil.Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology. Baltimore, MD, EUA.Cryptococcus neoformans is an encapsulated fungal pathogen that causes cryptococcosis, which is a major opportunistic infection in immunosuppressed individuals. Mammalian β-galactoside-binding protein Galectin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during microbial infections including some fungal diseases. Here we show that this protein plays a role also in C. neoformans infection. We find augmented Gal-3 serum levels in human and experimental infections, as well as in spleen, lung, and brain tissues of infected mice. Gal-3-deficient mice are more susceptible to cryptococcosis than WT animals, as demonstrated by the higher fungal burden and lower animal survival. In vitro experiments show that Gal-3 inhibits fungal growth and exerts a direct lytic effect on C. neoformans extracellular vesicles (EVs). Our results indicate a direct role for Gal-3 in antifungal immunity whereby this molecule affects the outcome of C. neoformans infection by inhibiting fungal growth and reducing EV stability, which in turn could benefit the host.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83101https://www.arca.fiocruz.br/bitstream/icict/27670/1/license.txt425ef259bcb460998407fbfed7c102d0MD51ORIGINALve_Marcio_Rodrigues_etal_CDTS_2017.pdfve_Marcio_Rodrigues_etal_CDTS_2017.pdfapplication/pdf1845707https://www.arca.fiocruz.br/bitstream/icict/27670/2/ve_Marcio_Rodrigues_etal_CDTS_2017.pdf9091e575909e76e0907054b59ce75780MD52TEXTve_Marcio_Rodrigues_etal_CDTS_2017.pdf.txtve_Marcio_Rodrigues_etal_CDTS_2017.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
title Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
spellingShingle Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Fausto
galectina
criptococcose
title_short Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
title_full Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
title_fullStr Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
title_full_unstemmed Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
title_sort Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
author Almeida, Fausto
author_facet Almeida, Fausto
Wolf, Julie M
da Silva, Thiago Aparecido
DeLeon-Rodriguez, Carlos M
Rezende, Caroline Patini
Pessoni, André Moreira
Fernandes, Fabrício Freitas
Silva-Rocha, Rafael
Martinez, Roberto
Rodrigues, Marcio Lourenço
Roque-Barreira, Maria Cristina
Casadevall, Arturo
author_role author
author2 Wolf, Julie M
da Silva, Thiago Aparecido
DeLeon-Rodriguez, Carlos M
Rezende, Caroline Patini
Pessoni, André Moreira
Fernandes, Fabrício Freitas
Silva-Rocha, Rafael
Martinez, Roberto
Rodrigues, Marcio Lourenço
Roque-Barreira, Maria Cristina
Casadevall, Arturo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Fausto
Wolf, Julie M
da Silva, Thiago Aparecido
DeLeon-Rodriguez, Carlos M
Rezende, Caroline Patini
Pessoni, André Moreira
Fernandes, Fabrício Freitas
Silva-Rocha, Rafael
Martinez, Roberto
Rodrigues, Marcio Lourenço
Roque-Barreira, Maria Cristina
Casadevall, Arturo
dc.subject.other.pt_BR.fl_str_mv galectina
criptococcose
topic galectina
criptococcose
description University of Sao Paulo. Ribeirao Preto Medical School. Department of Biochemistry and Immunology. Ribeirao Preto, SP, Brasil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-07-26T13:39:30Z
dc.date.available.fl_str_mv 2018-07-26T13:39:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, F. et al. Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects. Nature Communications, v. 8, p. 1968, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27670
dc.identifier.issn.pt_BR.fl_str_mv 2041-1723
dc.identifier.doi.none.fl_str_mv 10.1038/s41467-017-02126-7
identifier_str_mv ALMEIDA, F. et al. Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects. Nature Communications, v. 8, p. 1968, 2017.
2041-1723
10.1038/s41467-017-02126-7
url https://www.arca.fiocruz.br/handle/icict/27670
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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