Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects

Detalhes bibliográficos
Autor(a) principal: Frozza, Rudimar L.
Data de Publicação: 2018
Outros Autores: Lourenco, Mychael V., De Felice, Fernanda G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28479
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
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spelling Frozza, Rudimar L.Lourenco, Mychael V.De Felice, Fernanda G.2018-08-30T17:23:36Z2018-08-30T17:23:36Z2018FROZZA, Rudimar L.; LOURENÇO, Mychael V.; De FELICE, Fernanda G. Challenges for Alzheimer’s Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects. Frontiers in Neuroscience, v.12, Article 37, 13p, Feb. 2018.1662-4548,https://www.arca.fiocruz.br/handle/icict/2847910.3389/fnins.2018.000371662-453XengFrontiers MediaDoença de AlzheimerInflamaçãoTerapiadefeitos de memóriapré-clínicodesequilíbrios metabólicosAlzheimer’s diseaseInflammationmetabolic derangementsmemory defectspreclinicaltherapyChallenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Queen’s University,. Centre for Neuroscience Studies. Department of Biomedical and Molecular Sciences. Kingston, Ontario, Canada.Alzheimer's disease (AD), the most common form of dementia in late life, will become even more prevalent by midcentury, constituting a major global health concern with huge implications for individuals and society. Despite scientific breakthroughs during the past decades that have expanded our knowledge on the cellular and molecular bases of AD, therapies that effectively halt disease progression are still lacking, and focused efforts are needed to address this public health challenge. Because AD is classically recognized as a disease of memory, studies have mainly focused on investigating memory-associated brain defects. However, compelling evidence has indicated that additional brain regions, not classically linked to memory, are also affected in the course of disease. In this review, we outline the current understanding of key pathophysiological mechanisms in AD and their clinical manifestation. We also highlight how considering the complex nature of AD pathogenesis, and exploring repurposed drug approaches can pave the road toward the development of novel therapeutics for AD.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28479/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALrudimar_frozza_etal_IOC_2018.pdfrudimar_frozza_etal_IOC_2018.pdfapplication/pdf758599https://www.arca.fiocruz.br/bitstream/icict/28479/2/rudimar_frozza_etal_IOC_2018.pdf720c7f134b1377b2857a73a92ff7b84fMD52TEXTrudimar_frozza_etal_IOC_2018.pdf.txtrudimar_frozza_etal_IOC_2018.pdf.txtExtracted texttext/plain88580https://www.arca.fiocruz.br/bitstream/icict/28479/3/rudimar_frozza_etal_IOC_2018.pdf.txtb77b644a42f568e4a5883fe5fb18d3fbMD53icict/284792018-08-31 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dc.title.pt_BR.fl_str_mv Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
title Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
spellingShingle Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
Frozza, Rudimar L.
Doença de Alzheimer
Inflamação
Terapia
defeitos de memória
pré-clínico
desequilíbrios metabólicos
Alzheimer’s disease
Inflammation
metabolic derangements
memory defects
preclinical
therapy
title_short Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
title_full Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
title_fullStr Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
title_full_unstemmed Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
title_sort Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
author Frozza, Rudimar L.
author_facet Frozza, Rudimar L.
Lourenco, Mychael V.
De Felice, Fernanda G.
author_role author
author2 Lourenco, Mychael V.
De Felice, Fernanda G.
author2_role author
author
dc.contributor.author.fl_str_mv Frozza, Rudimar L.
Lourenco, Mychael V.
De Felice, Fernanda G.
dc.subject.other.pt_BR.fl_str_mv Doença de Alzheimer
Inflamação
Terapia
defeitos de memória
pré-clínico
desequilíbrios metabólicos
topic Doença de Alzheimer
Inflamação
Terapia
defeitos de memória
pré-clínico
desequilíbrios metabólicos
Alzheimer’s disease
Inflammation
metabolic derangements
memory defects
preclinical
therapy
dc.subject.en.pt_BR.fl_str_mv Alzheimer’s disease
Inflammation
metabolic derangements
memory defects
preclinical
therapy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-30T17:23:36Z
dc.date.available.fl_str_mv 2018-08-30T17:23:36Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FROZZA, Rudimar L.; LOURENÇO, Mychael V.; De FELICE, Fernanda G. Challenges for Alzheimer’s Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects. Frontiers in Neuroscience, v.12, Article 37, 13p, Feb. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28479
dc.identifier.issn.pt_BR.fl_str_mv 1662-4548,
dc.identifier.doi.none.fl_str_mv 10.3389/fnins.2018.00037
dc.identifier.eissn.none.fl_str_mv 1662-453X
identifier_str_mv FROZZA, Rudimar L.; LOURENÇO, Mychael V.; De FELICE, Fernanda G. Challenges for Alzheimer’s Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects. Frontiers in Neuroscience, v.12, Article 37, 13p, Feb. 2018.
1662-4548,
10.3389/fnins.2018.00037
1662-453X
url https://www.arca.fiocruz.br/handle/icict/28479
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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