Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35497 |
Resumo: | 2020-09-11 |
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Albuquerque, Raquel Cavalcanti deGranato, AlessandraCastro, Isabela SilvaTorres, Rafael CarvalhoSouza, Flávia SantosLima, Marco AntonioLeite, Ana Claudia Celestino BezerraEspíndola, Otávio de MeloEchevarria-Lima, Juliana2019-09-11T14:21:24Z2019-09-11T14:21:24Z2019ALBUQUERQUE, Raquel Cavalcanti de et al. Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers. Journal of Leukocyte Biology, v. 106, p. 607-618, 2019.0741-5400https://www.arca.fiocruz.br/handle/icict/3549710.1002/JLB.MA1118-467RengWileyPhenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-09-11Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Laboratório de Imunologia Básica e Aplicada. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Laboratório de Imunologia Básica e Aplicada. Rio de Janeiro, RJ, Brasil / Hospital for Sick Children.Program in Genetics and Genome Biology. Toronto, ON, Canada.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Laboratório de Imunologia Básica e Aplicada. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Plataforma de Imuno-Análise. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Laboratório de Imunologia Básica e Aplicada. Rio de Janeiro, RJ, Brasil.Human T-cell lymphotropic virus type-1 (HTLV-1) is the etiologic agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is a chronic inflammatory disease that leads to gradual loss of motor movement as a result of the death of spinal cord cells through immune mediated mechanisms. The risk to develop HAM/TSP disease positively correlates with the magnitude of HTLV-1 proviral load. Gamma-delta T lymphocytes have been recognized as important players in a variety of infectious diseases. Therefore, we have investigated interactions between HTLV-1 infection and γδ T lymphocytes during HAM/TSP. Similar frequencies of total γδ T lymphocytes and their Vγ9δ2+ and Vγ9δ2neg subpopulations were observed in HAM/TSP patients. However, T lymphocytes obtained from HTLV-1 carriers displayed significantly higher rates of spontaneous proliferation and NKp30 expression when compared to cells from uninfected donors. In addition, an important decrease in the frequency of granzyme B+ γδ T lymphocytes (approximately 50%) was observed in HAM/TSP patients. Higher proportion of IFN-γ+ γδ T lymphocytes was found in HTLV-1-infected patients, which positively correlated with the HTLV-1 proviral load in peripheral blood mononuclear cells. Collectively, our data indicates that HTLV-1 infection leads to phenotypic and functional changes in the population of γδ T lymphocyte population, suggesting that HTLV-1 infection modulates functions associated to these cells, which might be involved in controlling the infection or in the development of HTLV-1-associated diseases. T lymphocytesGranzyme BHTLV-1IFN-NKp30info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/35497/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Albuquerque_Raquel_etal_INI_2019.pdfve_Albuquerque_Raquel_etal_INI_2019.pdfapplication/pdf1717959https://www.arca.fiocruz.br/bitstream/icict/35497/2/ve_Albuquerque_Raquel_etal_INI_2019.pdfc90032aeb73534ab0d1ba1b87ce09d74MD52TEXTve_Albuquerque_Raquel_etal_INI_2019.pdf.txtve_Albuquerque_Raquel_etal_INI_2019.pdf.txtExtracted texttext/plain56328https://www.arca.fiocruz.br/bitstream/icict/35497/3/ve_Albuquerque_Raquel_etal_INI_2019.pdf.txt30de91cbc4fc413be0b6654a2f585cc1MD53icict/354972021-03-24 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| dc.title.pt_BR.fl_str_mv |
Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers |
| title |
Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers |
| spellingShingle |
Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers Albuquerque, Raquel Cavalcanti de T lymphocytes Granzyme B HTLV-1 IFN- NKp30 |
| title_short |
Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers |
| title_full |
Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers |
| title_fullStr |
Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers |
| title_full_unstemmed |
Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers |
| title_sort |
Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers |
| author |
Albuquerque, Raquel Cavalcanti de |
| author_facet |
Albuquerque, Raquel Cavalcanti de Granato, Alessandra Castro, Isabela Silva Torres, Rafael Carvalho Souza, Flávia Santos Lima, Marco Antonio Leite, Ana Claudia Celestino Bezerra Espíndola, Otávio de Melo Echevarria-Lima, Juliana |
| author_role |
author |
| author2 |
Granato, Alessandra Castro, Isabela Silva Torres, Rafael Carvalho Souza, Flávia Santos Lima, Marco Antonio Leite, Ana Claudia Celestino Bezerra Espíndola, Otávio de Melo Echevarria-Lima, Juliana |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Albuquerque, Raquel Cavalcanti de Granato, Alessandra Castro, Isabela Silva Torres, Rafael Carvalho Souza, Flávia Santos Lima, Marco Antonio Leite, Ana Claudia Celestino Bezerra Espíndola, Otávio de Melo Echevarria-Lima, Juliana |
| dc.subject.en.pt_BR.fl_str_mv |
T lymphocytes Granzyme B HTLV-1 IFN- NKp30 |
| topic |
T lymphocytes Granzyme B HTLV-1 IFN- NKp30 |
| description |
2020-09-11 |
| publishDate |
2019 |
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2019-09-11T14:21:24Z |
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2019-09-11T14:21:24Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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ALBUQUERQUE, Raquel Cavalcanti de et al. Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers. Journal of Leukocyte Biology, v. 106, p. 607-618, 2019. |
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https://www.arca.fiocruz.br/handle/icict/35497 |
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0741-5400 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/JLB.MA1118-467R |
| identifier_str_mv |
ALBUQUERQUE, Raquel Cavalcanti de et al. Phenotypic and functional changes in gamma delta T lymphocytes from HTLV-1 carriers. Journal of Leukocyte Biology, v. 106, p. 607-618, 2019. 0741-5400 10.1002/JLB.MA1118-467R |
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eng |
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Wiley |
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Wiley |
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