α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19666 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. |
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D`Almeida, Ana Paula L.Oliveira, Maria T. Pacheco deSouza, Éverton T. deCoutinho, Diego de SáCiambarella, Bianca T.Gomes, Cristiano R.Terroso, ThatianaGuterres, Sílvia S.Pohlmann, Adriana R.Martins, Marco A.Bernardi, Andressa2017-06-29T13:48:42Z2017-06-29T13:48:42Z2017D´ALMEIDA, Ana Paula L. et al. α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International Journal of Nanomedicine, v.12, p.4479-4491, June 2017.1176-9114https://www.arca.fiocruz.br/handle/icict/1966610.2147/IJN.S1307981178-2013engDove Medical PressSíndrome da insuficiência respiratória agudaNanotecnologiaEntrega de drogasInflamação pulmonarEfeitos anti-inflamatóriosA-bisabololacute respiratory distress syndromenanotechnologydrug deliverypulmonary inflammationα-bisabololanti-inflammatory effectsα-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós-Graduação em Ciências Farmacêuticas. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Instituto de Química. Departamento de Química Orgânica. Porto Alegre, RS, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Acute respiratory distress syndrome (ARDS) is a severe clinical condition of respiratory failure due to an intense inflammatory response with different etiologies. Despite all efforts, therapy remains limited, and ARDS is still associated with high mortality and morbidity. Plants can provide a vast source of active natural products for the discovery of new drugs. α-bisabolol (α-bis), a constituent of the essential oil from chamomile, has elicited pharmacological interest. However, the molecule has some limitations to its biological application. This study was conducted to develop a drug delivery system using lipid-core nanocapsules (LNCs) to improve the anti-inflammatory effects of orally administered α-bis. α-bis-loaded LNCs (α-bis-LNCs) were prepared by interfacial deposition of poly(ε-caprolactone) and orally administered in a mouse model of ARDS triggered by an intranasal administration of lipopolysaccharide (LPS). We found that α-bis-LNCs (30, 50, and 100 mg kg−1 ) significantly reduced airway hyperreactivity (AHR), neutrophil infiltration, myeloperoxidase activity, chemokine levels (KC and MIP-2), and tissue lung injury 18 hours after the LPS challenge. By contrast, free α-bis failed to modify AHR and neutrophil accumulation in the bronchoalveolar lavage effluent and lung parenchyma and inhibited elevation in the myeloperoxidase and MIP-2 levels only at the highest dose. Furthermore, only α-bis-LNCs reduced LPS-induced changes in mitogen-activated protein kinase signaling, as observed by a significant reduction in phosphorylation levels of ERK1/2, JNK, and p38 proteins. Taken together, our results clearly show that by using LNCs, α-bis was able to decrease LPS-induced inflammation. These findings may be explained by the robust increase of α-bis concentration in the lung tissue that was achieved by the LNCs. Altogether, these results indicate that α-bis-LNCs should further be investigated as a potential alternative for the treatment of ARDS.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19666/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALanapaula_almeida_etal_IOC_2017.pdfanapaula_almeida_etal_IOC_2017.pdfapplication/pdf4664131https://www.arca.fiocruz.br/bitstream/icict/19666/2/anapaula_almeida_etal_IOC_2017.pdf8400f87cfc78f005412e1be5ed94d36bMD52TEXTanapaula_almeida_etal_IOC_2017.pdf.txtanapaula_almeida_etal_IOC_2017.pdf.txtExtracted texttext/plain65547https://www.arca.fiocruz.br/bitstream/icict/19666/3/anapaula_almeida_etal_IOC_2017.pdf.txt14a0aa232a14fd35394a5a08b241991fMD53icict/196662018-08-15 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| dc.title.pt_BR.fl_str_mv |
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice |
| title |
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice |
| spellingShingle |
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice D`Almeida, Ana Paula L. Síndrome da insuficiência respiratória aguda Nanotecnologia Entrega de drogas Inflamação pulmonar Efeitos anti-inflamatórios A-bisabolol acute respiratory distress syndrome nanotechnology drug delivery pulmonary inflammation α-bisabolol anti-inflammatory effects |
| title_short |
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice |
| title_full |
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice |
| title_fullStr |
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice |
| title_full_unstemmed |
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice |
| title_sort |
α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice |
| author |
D`Almeida, Ana Paula L. |
| author_facet |
D`Almeida, Ana Paula L. Oliveira, Maria T. Pacheco de Souza, Éverton T. de Coutinho, Diego de Sá Ciambarella, Bianca T. Gomes, Cristiano R. Terroso, Thatiana Guterres, Sílvia S. Pohlmann, Adriana R. Martins, Marco A. Bernardi, Andressa |
| author_role |
author |
| author2 |
Oliveira, Maria T. Pacheco de Souza, Éverton T. de Coutinho, Diego de Sá Ciambarella, Bianca T. Gomes, Cristiano R. Terroso, Thatiana Guterres, Sílvia S. Pohlmann, Adriana R. Martins, Marco A. Bernardi, Andressa |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
D`Almeida, Ana Paula L. Oliveira, Maria T. Pacheco de Souza, Éverton T. de Coutinho, Diego de Sá Ciambarella, Bianca T. Gomes, Cristiano R. Terroso, Thatiana Guterres, Sílvia S. Pohlmann, Adriana R. Martins, Marco A. Bernardi, Andressa |
| dc.subject.other.pt_BR.fl_str_mv |
Síndrome da insuficiência respiratória aguda Nanotecnologia Entrega de drogas Inflamação pulmonar Efeitos anti-inflamatórios A-bisabolol |
| topic |
Síndrome da insuficiência respiratória aguda Nanotecnologia Entrega de drogas Inflamação pulmonar Efeitos anti-inflamatórios A-bisabolol acute respiratory distress syndrome nanotechnology drug delivery pulmonary inflammation α-bisabolol anti-inflammatory effects |
| dc.subject.en.pt_BR.fl_str_mv |
acute respiratory distress syndrome nanotechnology drug delivery pulmonary inflammation α-bisabolol anti-inflammatory effects |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. |
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2017 |
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2017-06-29T13:48:42Z |
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2017-06-29T13:48:42Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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D´ALMEIDA, Ana Paula L. et al. α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International Journal of Nanomedicine, v.12, p.4479-4491, June 2017. |
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https://www.arca.fiocruz.br/handle/icict/19666 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1176-9114 |
| dc.identifier.doi.none.fl_str_mv |
10.2147/IJN.S130798 |
| dc.identifier.eissn.none.fl_str_mv |
1178-2013 |
| identifier_str_mv |
D´ALMEIDA, Ana Paula L. et al. α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International Journal of Nanomedicine, v.12, p.4479-4491, June 2017. 1176-9114 10.2147/IJN.S130798 1178-2013 |
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Dove Medical Press |
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Dove Medical Press |
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