Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40174 |
Resumo: | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil. |
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Amaral, Ana Claudia FernandesGomes, Luciana A.Silva, Jefferson Rocha de AndradeFerreira, José Luiz PintoRamos, Aline de SouzaRosa, Maria do Socorro S.Vermelho, Alane B.Rodrigues, Igor A.2020-03-02T19:35:28Z2020-03-02T19:35:28Z2014AMARAL, Ana Claudia F. et al. Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity. BioMed Research International, p. 1-9, 2014.2314-6141https://www.arca.fiocruz.br/handle/icict/4017410.1155/2014/694934engLiposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Amazonas. Departamento de Química. Laboratório de Cromatografia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Produtos Naturais e Alimentos. Rio de Janeiro, RJ, Brasil.Promastigote forms of Leishmania amazonensis were treated with different concentrations of two fractions of Curcuma longa cortex rich in turmerones and their respective liposomal formulations in order to evaluate growth inhibition and the minimal inhibitory concentration (MIC). In addition, cellular alterations of treated promastigotes were investigated under transmission and scanning electron microscopies. LipoRHIC and LipoRHIWC presented lower MIC, 5.5 and 12.5 g/mL, when compared to nonencapsulated fractions (125 and 250 g/mL), respectively, and to ar-turmerone (50 g/mL). Parasite growth inhibition was demonstrated to be dose-dependent. Important morphological changes as rounded body and presence of several roles on plasmatic membrane could be seen on L. amazonensis promastigotes after treatment with subinhibitory concentration (2.75 g/mL) of the most active LipoRHIC. In that sense, the hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation (LipoRHIC) could represent good strategy for the development of new antileishmanial agent.Liposomal FormulationTurmerone-Rich Hexane FractionsCurcumaAntileishmanial Activityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83093https://www.arca.fiocruz.br/bitstream/icict/40174/1/license.txt34529d73b0c3f33b39c969c511d590fbMD51ORIGINAL694934.pdf694934.pdfapplication/pdf2616316https://www.arca.fiocruz.br/bitstream/icict/40174/2/694934.pdf198937aee2773de187ac8afcb0aeceb7MD52TEXT694934.pdf.txt694934.pdf.txtExtracted texttext/plain37709https://www.arca.fiocruz.br/bitstream/icict/40174/3/694934.pdf.txt5ea24c7c800090d1cd71634e3ecab297MD53icict/401742021-06-01 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| dc.title.pt_BR.fl_str_mv |
Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity |
| title |
Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity |
| spellingShingle |
Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity Amaral, Ana Claudia Fernandes Liposomal Formulation Turmerone-Rich Hexane Fractions Curcuma Antileishmanial Activity |
| title_short |
Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity |
| title_full |
Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity |
| title_fullStr |
Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity |
| title_full_unstemmed |
Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity |
| title_sort |
Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity |
| author |
Amaral, Ana Claudia Fernandes |
| author_facet |
Amaral, Ana Claudia Fernandes Gomes, Luciana A. Silva, Jefferson Rocha de Andrade Ferreira, José Luiz Pinto Ramos, Aline de Souza Rosa, Maria do Socorro S. Vermelho, Alane B. Rodrigues, Igor A. |
| author_role |
author |
| author2 |
Gomes, Luciana A. Silva, Jefferson Rocha de Andrade Ferreira, José Luiz Pinto Ramos, Aline de Souza Rosa, Maria do Socorro S. Vermelho, Alane B. Rodrigues, Igor A. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Amaral, Ana Claudia Fernandes Gomes, Luciana A. Silva, Jefferson Rocha de Andrade Ferreira, José Luiz Pinto Ramos, Aline de Souza Rosa, Maria do Socorro S. Vermelho, Alane B. Rodrigues, Igor A. |
| dc.subject.en.pt_BR.fl_str_mv |
Liposomal Formulation Turmerone-Rich Hexane Fractions Curcuma Antileishmanial Activity |
| topic |
Liposomal Formulation Turmerone-Rich Hexane Fractions Curcuma Antileishmanial Activity |
| description |
Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Departamento de Produtos Naturais. Laboratório de Plantas Medicinais e Derivados. Rio de Janeiro, RJ, Brasil. |
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2014 |
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2014 |
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2020-03-02T19:35:28Z |
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2020-03-02T19:35:28Z |
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AMARAL, Ana Claudia F. et al. Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity. BioMed Research International, p. 1-9, 2014. |
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https://www.arca.fiocruz.br/handle/icict/40174 |
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2314-6141 |
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10.1155/2014/694934 |
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AMARAL, Ana Claudia F. et al. Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity. BioMed Research International, p. 1-9, 2014. 2314-6141 10.1155/2014/694934 |
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