Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination

Rezende, Izabela Maurício de; Alves, Pedro Augusto; Arruda, Matheus Soares; Gonçalves, Andreza Parreiras; Oliveira, Gabriela Fernanda Garcia; Pereira, Leonardo Soares; Dutra, Maria Rita Teixeira; Azevedo, Ana Carolina Campi; Valim, Valéria; Tourinho, Renata; Oliveira, Jaquelline Germano de; Calzavara, Carlos Eduardo; Said, Rodrigo Fabiano do Carmo; Kroon, Erna Geessien; Martins Filho, Olindo Assis; Carvalho, Andrea Teixeira de; Drumond, Betânia Paiva

Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination

Detalhes bibliográficos
Autor(a) principal:	Rezende, Izabela Maurício de
Data de Publicação:	2019
Outros Autores:	Alves, Pedro Augusto, Arruda, Matheus Soares, Gonçalves, Andreza Parreiras, Oliveira, Gabriela Fernanda Garcia, Pereira, Leonardo Soares, Dutra, Maria Rita Teixeira, Azevedo, Ana Carolina Campi, Valim, Valéria, Tourinho, Renata, Oliveira, Jaquelline Germano de, Calzavara, Carlos Eduardo, Said, Rodrigo Fabiano do Carmo, Kroon, Erna Geessien, Martins Filho, Olindo Assis, Carvalho, Andrea Teixeira de, Drumond, Betânia Paiva
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/41493
Resumo:	Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil

Metadados do item

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spelling	Rezende, Izabela Maurício deAlves, Pedro AugustoArruda, Matheus SoaresGonçalves, Andreza ParreirasOliveira, Gabriela Fernanda GarciaPereira, Leonardo SoaresDutra, Maria Rita TeixeiraAzevedo, Ana Carolina CampiValim, ValériaTourinho, RenataOliveira, Jaquelline Germano deCalzavara, Carlos EduardoSaid, Rodrigo Fabiano do CarmoKroon, Erna GeessienMartins Filho, Olindo AssisCarvalho, Andrea Teixeira deDrumond, Betânia Paiva2020-06-02T19:55:41Z2020-06-02T19:55:41Z2019REZENDE, Izabela Maurício et al. Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination. Vaccines, v. 7, n. 4, 206, 20192076-393Xhttps://www.arca.fiocruz.br/handle/icict/4149310.3390/vaccines7040206engMDPI AGYellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccinationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil/ Fundação Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, BrazilFundação Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil Ana Carolina Campi AzevedoFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilEmpresa Brasileira de Serviços Hospitalares. Universidade Federal do Espírito Santo. Hospital Universitário Cassiano Antônio Moraes. Vitória, ES, BrazilFundação Oswaldo Cruz. Biomanguinhos. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilSecretaria de Estado de Saúde de Minas Gerais. Belo Horizonte, MG, Brazil/Ministério da Saúde. Secretaria de Vigilância em Saúde Departamento de Vigilância das Doenças Transmissíveis. Brasília, DF, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, BrazilThe yellow fever (YF) vaccine consists of an attenuated virus, and despite its relative safety, some adverse events following YF vaccination have been described. At the end of 2016, Brazil experienced the most massive sylvatic yellow fever outbreak over the last 70 years and an intense campaign of YF vaccination occurred in Minas Gerais state in Southeast Brazil from 2016 to 2018. The present study aimed to develop a genotyping tool and investigate 21 cases of suspected adverse events following YF vaccination. Initial in silico analyses were performed using partial NS5 nucleotide sequences to verify the discriminatory potential between wild-type and vaccine viruses. Samples from patients were screened for the presence of the YFV RNA, using 50UTR as the target, and then used for amplification of partial NS5 gene amplification, sequencing, and phylogenetic analysis. Genotyping indicated that 17 suspected cases were infected by the wild-type yellow fever virus, but four cases remained inconclusive. The genotyping tool was e_cient in distinguishing the vaccine from wild-type virus, and it has the potential to be used for the di_erentiation of all yellow fever virus genotypes.yellow fever virusYFV-17DDadverse eventarbovirusyellow fevervaccinationimmunisationvaccinegenotypingwild-type virusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/41493/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIRR - vaccines-07-00206.pdfIRR - vaccines-07-00206.pdfapplication/pdf1391053https://www.arca.fiocruz.br/bitstream/icict/41493/2/IRR%20-%20vaccines-07-00206.pdf6faf8b0596b6b7c4bf7ad7785991b382MD52TEXTIRR - vaccines-07-00206.pdf.txtIRR - vaccines-07-00206.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination
title	Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination
spellingShingle	Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination Rezende, Izabela Maurício de yellow fever virus YFV-17DD adverse event arbovirus yellow fever vaccination immunisation vaccine genotyping wild-type virus
title_short	Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination
title_full	Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination
title_fullStr	Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination
title_full_unstemmed	Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination
title_sort	Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination
author	Rezende, Izabela Maurício de
author_facet	Rezende, Izabela Maurício de Alves, Pedro Augusto Arruda, Matheus Soares Gonçalves, Andreza Parreiras Oliveira, Gabriela Fernanda Garcia Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Azevedo, Ana Carolina Campi Valim, Valéria Tourinho, Renata Oliveira, Jaquelline Germano de Calzavara, Carlos Eduardo Said, Rodrigo Fabiano do Carmo Kroon, Erna Geessien Martins Filho, Olindo Assis Carvalho, Andrea Teixeira de Drumond, Betânia Paiva
author_role	author
author2	Alves, Pedro Augusto Arruda, Matheus Soares Gonçalves, Andreza Parreiras Oliveira, Gabriela Fernanda Garcia Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Azevedo, Ana Carolina Campi Valim, Valéria Tourinho, Renata Oliveira, Jaquelline Germano de Calzavara, Carlos Eduardo Said, Rodrigo Fabiano do Carmo Kroon, Erna Geessien Martins Filho, Olindo Assis Carvalho, Andrea Teixeira de Drumond, Betânia Paiva
author2_role	author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Rezende, Izabela Maurício de Alves, Pedro Augusto Arruda, Matheus Soares Gonçalves, Andreza Parreiras Oliveira, Gabriela Fernanda Garcia Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Azevedo, Ana Carolina Campi Valim, Valéria Tourinho, Renata Oliveira, Jaquelline Germano de Calzavara, Carlos Eduardo Said, Rodrigo Fabiano do Carmo Kroon, Erna Geessien Martins Filho, Olindo Assis Carvalho, Andrea Teixeira de Drumond, Betânia Paiva
dc.subject.en.pt_BR.fl_str_mv	yellow fever virus YFV-17DD adverse event arbovirus yellow fever vaccination immunisation vaccine genotyping wild-type virus
topic	yellow fever virus YFV-17DD adverse event arbovirus yellow fever vaccination immunisation vaccine genotyping wild-type virus
description	Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil
publishDate	2019
dc.date.issued.fl_str_mv	2019
dc.date.accessioned.fl_str_mv	2020-06-02T19:55:41Z
dc.date.available.fl_str_mv	2020-06-02T19:55:41Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	REZENDE, Izabela Maurício et al. Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination. Vaccines, v. 7, n. 4, 206, 2019
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/41493
dc.identifier.issn.pt_BR.fl_str_mv	2076-393X
dc.identifier.doi.none.fl_str_mv	10.3390/vaccines7040206
identifier_str_mv	REZENDE, Izabela Maurício et al. Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination. Vaccines, v. 7, n. 4, 206, 2019 2076-393X 10.3390/vaccines7040206
url	https://www.arca.fiocruz.br/handle/icict/41493
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	MDPI AG
publisher.none.fl_str_mv	MDPI AG
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/41493/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/41493/2/IRR%20-%20vaccines-07-00206.pdf https://www.arca.fiocruz.br/bitstream/icict/41493/3/IRR%20-%20vaccines-07-00206.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination

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