Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10631 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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Sánchez-Arcila, Juan CamiloSilva, Daiana de Souza Perce daVasconcelos, Mariana Pinheiro AlvesSilva, Rodrigo Nunes Rodrigues daPereira, Virginia AraujoAprígio, Cesarino Junior LimaLima, Cleoni Alves MendesFonseca, Bruna de Paula Fonseca eBank, Dalma MariaLima Junior, Josué da CostaFerreira, Joseli Oliveira2015-06-01T19:34:27Z2015-06-01T19:34:27Z2014SÀNCHEZ-ARCILA, Juan Camilo et al. Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil. Mediators of Inflamation, v.2014, Article ID857245, 12p, 2014.1466-1861https://www.arca.fiocruz.br/handle/icict/1063110.1155/2014/857245engHindawi Publishing CorporationParasitosMaláriaRegião AmazônicaMalariaAmazon regionIntestinal parasitesIntestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ, Brasil.Instituto de Infectologia Emílio Ribas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Agência de Vigilância em Saúde da Secretaria de Estado da Saúde (AGEVISA). Porto Velho, RO, Brasil.Universidade Federal de Rondônia. Centro Interdepartamental de Biologia Experimental e Biotecnologia. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Diagnóstica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.In Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore the interaction between malaria and other parasites. Therefore, the present study evaluates changes in cytokine, chemokine, C-reactive protein, and nitric oxide (NO) concentrations in 264 individuals, comparing plasma frominfected individualswith concurrentmalaria and intestinal parasites to individualswith eithermalaria infection alone and uninfected. In the studied population 24% of the individuals were infected with Plasmodium and 18%coinfected with intestinal parasites. Protozoan parasites comprised the bulk of the intestinal parasites infections and subjects infected with intestinal parasites were more likely to have malaria. The use of principal component analysis and cluster analysis associated increased levels of IL-6, TNF-, IL-10, and CRPand lowlevels of IL-17Apredominantlywith individuals with malaria alone and coinfected individuals. In contrast, lowlevels of almost all inflammatory mediatorswere associated predominantlywith individuals uninfectedwhile increased levels of IL-17Awere associated predominantly with individuals with intestinal parasites only. In conclusion, our data suggest that, in our population, the infection with intestinal parasites (mainly protozoan) does not modify the pattern of cytokine production in individuals infected with P. falciparum and P. vivaxinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10631/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALjuan_arcilaetal_IOC_2014.pdfapplication/pdf1663827https://www.arca.fiocruz.br/bitstream/icict/10631/2/juan_arcilaetal_IOC_2014.pdf38e99a74f44db72db66a4e439c42f531MD52TEXTjuan_arcilaetal_IOC_2014.pdf.txtjuan_arcilaetal_IOC_2014.pdf.txtExtracted texttext/plain59611https://www.arca.fiocruz.br/bitstream/icict/10631/3/juan_arcilaetal_IOC_2014.pdf.txt54c8e9b40033a24dee660f8d183295d6MD53icict/106312022-06-24 13:10:48.592oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title |
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| spellingShingle |
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil Sánchez-Arcila, Juan Camilo Parasitos Malária Região Amazônica Malaria Amazon region Intestinal parasites |
| title_short |
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_full |
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_fullStr |
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_full_unstemmed |
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| title_sort |
Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil |
| author |
Sánchez-Arcila, Juan Camilo |
| author_facet |
Sánchez-Arcila, Juan Camilo Silva, Daiana de Souza Perce da Vasconcelos, Mariana Pinheiro Alves Silva, Rodrigo Nunes Rodrigues da Pereira, Virginia Araujo Aprígio, Cesarino Junior Lima Lima, Cleoni Alves Mendes Fonseca, Bruna de Paula Fonseca e Bank, Dalma Maria Lima Junior, Josué da Costa Ferreira, Joseli Oliveira |
| author_role |
author |
| author2 |
Silva, Daiana de Souza Perce da Vasconcelos, Mariana Pinheiro Alves Silva, Rodrigo Nunes Rodrigues da Pereira, Virginia Araujo Aprígio, Cesarino Junior Lima Lima, Cleoni Alves Mendes Fonseca, Bruna de Paula Fonseca e Bank, Dalma Maria Lima Junior, Josué da Costa Ferreira, Joseli Oliveira |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sánchez-Arcila, Juan Camilo Silva, Daiana de Souza Perce da Vasconcelos, Mariana Pinheiro Alves Silva, Rodrigo Nunes Rodrigues da Pereira, Virginia Araujo Aprígio, Cesarino Junior Lima Lima, Cleoni Alves Mendes Fonseca, Bruna de Paula Fonseca e Bank, Dalma Maria Lima Junior, Josué da Costa Ferreira, Joseli Oliveira |
| dc.subject.other.pt_BR.fl_str_mv |
Parasitos Malária Região Amazônica |
| topic |
Parasitos Malária Região Amazônica Malaria Amazon region Intestinal parasites |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Amazon region Intestinal parasites |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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2014 |
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2014 |
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2015-06-01T19:34:27Z |
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2015-06-01T19:34:27Z |
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info:eu-repo/semantics/article |
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SÀNCHEZ-ARCILA, Juan Camilo et al. Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil. Mediators of Inflamation, v.2014, Article ID857245, 12p, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10631 |
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1466-1861 |
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10.1155/2014/857245 |
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SÀNCHEZ-ARCILA, Juan Camilo et al. Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil. Mediators of Inflamation, v.2014, Article ID857245, 12p, 2014. 1466-1861 10.1155/2014/857245 |
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