Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9586 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil. |
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Azevedo, Ana Carolina CampiEstevam, Paula de AlmeidaReis, Jordana Grazziela Alves Coelho dosMagalhães, Vanessa PeruhypeRezende, Gabriela VillelaQuaresma, Patrícia FláviaMaia, Maria de Lourdes SousaFarias, Roberto Henrique GuedesCamacho, Luiz Antonio BastosGaller, RicardoYamamura, Anna Maya YoshidaAlmeida, Luiz Fernando CarvalhoLima, Sheila Maria BarbosaNogueira, Rita Maria RibeiroSá, Gloria Regina SilvaHokama, Darcy AkemiCarvalho, Ricardo deFreire, Ricardo Aguiar VillanovaPereira Filho, EdsonLeal, Maria da Luz FernandesHomma, AkiraCarvalho, Andréa TeixeiraMartins, Reinaldo de MenezesMartins Filho, Olindo Assis2015-03-02T19:12:15Z2015-03-02T19:12:15Z2014AZEVEDO, Ana Carolina Campi et al. Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline. BMC Infectious Diseases, v. 14, p. 1-12, 2014.471-2334https://www.arca.fiocruz.br/handle/icict/958610.1186/1471-2334-14-391engBioMed CentralSubdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timelineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro,RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil.Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil.Background: The live attenuated 17DD Yellow Fever vaccine is one of the most successful prophylactic interventions for controlling disease expansion ever designed and utilized in larger scale. However, increase on worldwide vaccine demands and manufacturing restrictions urge for more detailed dose sparing studies. The establishment of complementary biomarkers in addition to PRNT and Viremia could support a secure decision-making regarding the use of 17DD YF vaccine subdoses. The present work aimed at comparing the serum chemokine and cytokine kinetics triggered by five subdoses of 17DD YF Vaccine. Methods: Neutralizing antibody titers, viremia, cytokines and chemokines were tested on blood samples obtained from eligible primary vaccinees. Results and discussion: The results demonstrated that a fifty-fold lower dose of 17DD-YF vaccine (587 IU) is able to trigger similar immunogenicity, as evidenced by significant titers of anti-YF PRNT. However, only subdoses as low as 3,013 IU elicit viremia kinetics with an early peak at five days after primary vaccination equivalent to the current dose (27,476 IU), while other subdoses show a distinct, lower in magnitude and later peak at day 6 post-vaccination. Although the subdose of 587 IU is able to trigger equivalent kinetics of IL-8/CXCL-8 and MCP-1/CCL-2, only the subdose of 3,013 IU is able to trigger similar kinetics of MIG/CXCL-9, pro-inflammatory (TNF, IFN-γ and IL-2) and modulatory cytokines (IL-5 and IL-10). Conclusions: The analysis of serum biomarkers IFN-γ and IL-10, in association to PRNT and viremia, support the recommendation of use of a ten-fold lower subdose (3,013 IU) of 17DD-YF vaccine.Yellow feverVaccineDose–responseViremiaCytokinesCkemokinesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9586/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_133.pdf2014_133.pdfapplication/pdf1767507https://www.arca.fiocruz.br/bitstream/icict/9586/2/2014_133.pdf7391488fb6c7b01f4d8694e5da140f58MD52TEXT2014_133.pdf.txt2014_133.pdf.txtExtracted texttext/plain43051https://www.arca.fiocruz.br/bitstream/icict/9586/3/2014_133.pdf.txtd73d5fee29dd9b209422c43a6dd27cf4MD53icict/95862023-09-14 16:02:24.29oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T19:02:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline |
| title |
Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline |
| spellingShingle |
Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline Azevedo, Ana Carolina Campi Yellow fever Vaccine Dose–response Viremia Cytokines Ckemokines |
| title_short |
Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline |
| title_full |
Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline |
| title_fullStr |
Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline |
| title_full_unstemmed |
Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline |
| title_sort |
Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline |
| author |
Azevedo, Ana Carolina Campi |
| author_facet |
Azevedo, Ana Carolina Campi Estevam, Paula de Almeida Reis, Jordana Grazziela Alves Coelho dos Magalhães, Vanessa Peruhype Rezende, Gabriela Villela Quaresma, Patrícia Flávia Maia, Maria de Lourdes Sousa Farias, Roberto Henrique Guedes Camacho, Luiz Antonio Bastos Galler, Ricardo Yamamura, Anna Maya Yoshida Almeida, Luiz Fernando Carvalho Lima, Sheila Maria Barbosa Nogueira, Rita Maria Ribeiro Sá, Gloria Regina Silva Hokama, Darcy Akemi Carvalho, Ricardo de Freire, Ricardo Aguiar Villanova Pereira Filho, Edson Leal, Maria da Luz Fernandes Homma, Akira Carvalho, Andréa Teixeira Martins, Reinaldo de Menezes Martins Filho, Olindo Assis |
| author_role |
author |
| author2 |
Estevam, Paula de Almeida Reis, Jordana Grazziela Alves Coelho dos Magalhães, Vanessa Peruhype Rezende, Gabriela Villela Quaresma, Patrícia Flávia Maia, Maria de Lourdes Sousa Farias, Roberto Henrique Guedes Camacho, Luiz Antonio Bastos Galler, Ricardo Yamamura, Anna Maya Yoshida Almeida, Luiz Fernando Carvalho Lima, Sheila Maria Barbosa Nogueira, Rita Maria Ribeiro Sá, Gloria Regina Silva Hokama, Darcy Akemi Carvalho, Ricardo de Freire, Ricardo Aguiar Villanova Pereira Filho, Edson Leal, Maria da Luz Fernandes Homma, Akira Carvalho, Andréa Teixeira Martins, Reinaldo de Menezes Martins Filho, Olindo Assis |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Azevedo, Ana Carolina Campi Estevam, Paula de Almeida Reis, Jordana Grazziela Alves Coelho dos Magalhães, Vanessa Peruhype Rezende, Gabriela Villela Quaresma, Patrícia Flávia Maia, Maria de Lourdes Sousa Farias, Roberto Henrique Guedes Camacho, Luiz Antonio Bastos Galler, Ricardo Yamamura, Anna Maya Yoshida Almeida, Luiz Fernando Carvalho Lima, Sheila Maria Barbosa Nogueira, Rita Maria Ribeiro Sá, Gloria Regina Silva Hokama, Darcy Akemi Carvalho, Ricardo de Freire, Ricardo Aguiar Villanova Pereira Filho, Edson Leal, Maria da Luz Fernandes Homma, Akira Carvalho, Andréa Teixeira Martins, Reinaldo de Menezes Martins Filho, Olindo Assis |
| dc.subject.en.pt_BR.fl_str_mv |
Yellow fever Vaccine Dose–response Viremia Cytokines Ckemokines |
| topic |
Yellow fever Vaccine Dose–response Viremia Cytokines Ckemokines |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, Minas Gerais, Brasil. |
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2014 |
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2014 |
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2015-03-02T19:12:15Z |
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2015-03-02T19:12:15Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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AZEVEDO, Ana Carolina Campi et al. Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline. BMC Infectious Diseases, v. 14, p. 1-12, 2014. |
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https://www.arca.fiocruz.br/handle/icict/9586 |
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471-2334 |
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10.1186/1471-2334-14-391 |
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AZEVEDO, Ana Carolina Campi et al. Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline. BMC Infectious Diseases, v. 14, p. 1-12, 2014. 471-2334 10.1186/1471-2334-14-391 |
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BioMed Central |
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BioMed Central |
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