Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case

Detalhes bibliográficos
Autor(a) principal: Nassar, Elza da S.
Data de Publicação: 1995
Outros Autores: Chamelet, Esther L. B., Coimbra, Terezinha L. M., Souza, Luiza T. M. de, Suzuki, Akemi, Ferreira, Ivani B., Silva, Marcos V. da, Rocco, Iray M., Rosa, Amélia P. A. Travassos da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/29286
Resumo: The authors report the clinical, laboratorial and epidemiological aspects of a human case of jungle yellow fever. The patient suffered from fever, chills, sweating, headaches, backaches, myalgia, epigastric pains, nausea, vomiting, diarrhea and prostration. He was unvaccinated and had been working in areas where cases of jungle yellow fever had been confirmed. Investigations concerning the yellow fever virus were performed. Blood samples were collected on several days in the course of the illness. Three of these samples (those obtained on days 5,7 and 10) were inoculated into suckling mice in attempt to isolate virus and to titrate the viremia level. Serological surveys were carried out by using the IgM Antibodies Capture Enzyme Linked Immunosorbent Assay (MAC-ELISA), Complement Fixation (CF), Hemagglulinalion Inhibition (HI) and Neutralization (N) tests. The yellow fever virus, recovered from the two first samples and the virus titration, showed high level of viremia. After that, specific antibodies appeared in all samples. The interval between the end of the viremia and the appearance of the antibodies was associated with the worsening of clinical symptoms, including bleeding of the mucous membrane. One must be aware of the risk of having a urban epidemics in areas where Aedes aegypti is found in high infestation indexes.
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spelling Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case Febre amarela silvestre: estudo clínico e laboratorial, enfatizando a viremia, de um caso humano ArbovirusJungle yellow feverViremiaClinical and laboratorial diagnosis The authors report the clinical, laboratorial and epidemiological aspects of a human case of jungle yellow fever. The patient suffered from fever, chills, sweating, headaches, backaches, myalgia, epigastric pains, nausea, vomiting, diarrhea and prostration. He was unvaccinated and had been working in areas where cases of jungle yellow fever had been confirmed. Investigations concerning the yellow fever virus were performed. Blood samples were collected on several days in the course of the illness. Three of these samples (those obtained on days 5,7 and 10) were inoculated into suckling mice in attempt to isolate virus and to titrate the viremia level. Serological surveys were carried out by using the IgM Antibodies Capture Enzyme Linked Immunosorbent Assay (MAC-ELISA), Complement Fixation (CF), Hemagglulinalion Inhibition (HI) and Neutralization (N) tests. The yellow fever virus, recovered from the two first samples and the virus titration, showed high level of viremia. After that, specific antibodies appeared in all samples. The interval between the end of the viremia and the appearance of the antibodies was associated with the worsening of clinical symptoms, including bleeding of the mucous membrane. One must be aware of the risk of having a urban epidemics in areas where Aedes aegypti is found in high infestation indexes. Os autores estudaram um caso humano de febre amarela silvestre, sob os aspectos clínico, laboratorial e epidemiológico. O paciente apresentava febre (39ºC), calafrios, sudorese, cefaléia, dor lombar, mialgia, dor abdominal em epigástrio, náuseas, vômitos, diarréia e prostração. Relatava permanência em área onde foram constatados casos de febre amarela silvestre e não havia histórico de vacinação anterior. Frente às suspeitas que levaram à investigação do vírus da febre amarela, foram colhidas várias amostras de sangue no curso da doença. As amostras do 5º, 7º e 10º dias foram submetidas a provas de isolamento e quantificação do vírus, o que possibilitou o estudo da viremia. Empregando-se os testes de MAC-ELISA (detecção de IgM), Fixação de Complemento (FC), Inibição de Hemaglutinação (IH) e teste de Neutralização (N), foi observada a resposta imune para anticorpos específicos nas amostras do 7º ao 26º dias. Os resultados mostraram que no 5º e 7º dias havia persistência da fase virêmica, com títulos elevados. Ao término desta fase, com o aparecimento de anticorpos específicos, foi observado um agravamento do quadro clínico, com sangramento de mucosas. Os autores alertam para a possibilidade de ocorrerem epidemias urbanas em áreas com alta infestação de Aedes aegypti. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1995-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29286Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 4 (1995); 337-341 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 4 (1995); 337-341 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 4 (1995); 337-341 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29286/31143Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessNassar, Elza da S.Chamelet, Esther L. B.Coimbra, Terezinha L. M.Souza, Luiza T. M. deSuzuki, AkemiFerreira, Ivani B.Silva, Marcos V. daRocco, Iray M.Rosa, Amélia P. A. Travassos da2012-07-02T01:40:33Zoai:revistas.usp.br:article/29286Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:02.091764Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
Febre amarela silvestre: estudo clínico e laboratorial, enfatizando a viremia, de um caso humano
title Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
spellingShingle Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
Nassar, Elza da S.
Arbovirus
Jungle yellow fever
Viremia
Clinical and laboratorial diagnosis
title_short Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
title_full Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
title_fullStr Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
title_full_unstemmed Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
title_sort Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
author Nassar, Elza da S.
author_facet Nassar, Elza da S.
Chamelet, Esther L. B.
Coimbra, Terezinha L. M.
Souza, Luiza T. M. de
Suzuki, Akemi
Ferreira, Ivani B.
Silva, Marcos V. da
Rocco, Iray M.
Rosa, Amélia P. A. Travassos da
author_role author
author2 Chamelet, Esther L. B.
Coimbra, Terezinha L. M.
Souza, Luiza T. M. de
Suzuki, Akemi
Ferreira, Ivani B.
Silva, Marcos V. da
Rocco, Iray M.
Rosa, Amélia P. A. Travassos da
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nassar, Elza da S.
Chamelet, Esther L. B.
Coimbra, Terezinha L. M.
Souza, Luiza T. M. de
Suzuki, Akemi
Ferreira, Ivani B.
Silva, Marcos V. da
Rocco, Iray M.
Rosa, Amélia P. A. Travassos da
dc.subject.por.fl_str_mv Arbovirus
Jungle yellow fever
Viremia
Clinical and laboratorial diagnosis
topic Arbovirus
Jungle yellow fever
Viremia
Clinical and laboratorial diagnosis
description The authors report the clinical, laboratorial and epidemiological aspects of a human case of jungle yellow fever. The patient suffered from fever, chills, sweating, headaches, backaches, myalgia, epigastric pains, nausea, vomiting, diarrhea and prostration. He was unvaccinated and had been working in areas where cases of jungle yellow fever had been confirmed. Investigations concerning the yellow fever virus were performed. Blood samples were collected on several days in the course of the illness. Three of these samples (those obtained on days 5,7 and 10) were inoculated into suckling mice in attempt to isolate virus and to titrate the viremia level. Serological surveys were carried out by using the IgM Antibodies Capture Enzyme Linked Immunosorbent Assay (MAC-ELISA), Complement Fixation (CF), Hemagglulinalion Inhibition (HI) and Neutralization (N) tests. The yellow fever virus, recovered from the two first samples and the virus titration, showed high level of viremia. After that, specific antibodies appeared in all samples. The interval between the end of the viremia and the appearance of the antibodies was associated with the worsening of clinical symptoms, including bleeding of the mucous membrane. One must be aware of the risk of having a urban epidemics in areas where Aedes aegypti is found in high infestation indexes.
publishDate 1995
dc.date.none.fl_str_mv 1995-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/29286
url https://www.revistas.usp.br/rimtsp/article/view/29286
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/29286/31143
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 4 (1995); 337-341
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 4 (1995); 337-341
Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 4 (1995); 337-341
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
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instname_str Instituto de Medicina Tropical (IMT)
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reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
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