Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/29286 |
Resumo: | The authors report the clinical, laboratorial and epidemiological aspects of a human case of jungle yellow fever. The patient suffered from fever, chills, sweating, headaches, backaches, myalgia, epigastric pains, nausea, vomiting, diarrhea and prostration. He was unvaccinated and had been working in areas where cases of jungle yellow fever had been confirmed. Investigations concerning the yellow fever virus were performed. Blood samples were collected on several days in the course of the illness. Three of these samples (those obtained on days 5,7 and 10) were inoculated into suckling mice in attempt to isolate virus and to titrate the viremia level. Serological surveys were carried out by using the IgM Antibodies Capture Enzyme Linked Immunosorbent Assay (MAC-ELISA), Complement Fixation (CF), Hemagglulinalion Inhibition (HI) and Neutralization (N) tests. The yellow fever virus, recovered from the two first samples and the virus titration, showed high level of viremia. After that, specific antibodies appeared in all samples. The interval between the end of the viremia and the appearance of the antibodies was associated with the worsening of clinical symptoms, including bleeding of the mucous membrane. One must be aware of the risk of having a urban epidemics in areas where Aedes aegypti is found in high infestation indexes. |
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Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case Febre amarela silvestre: estudo clínico e laboratorial, enfatizando a viremia, de um caso humano ArbovirusJungle yellow feverViremiaClinical and laboratorial diagnosis The authors report the clinical, laboratorial and epidemiological aspects of a human case of jungle yellow fever. The patient suffered from fever, chills, sweating, headaches, backaches, myalgia, epigastric pains, nausea, vomiting, diarrhea and prostration. He was unvaccinated and had been working in areas where cases of jungle yellow fever had been confirmed. Investigations concerning the yellow fever virus were performed. Blood samples were collected on several days in the course of the illness. Three of these samples (those obtained on days 5,7 and 10) were inoculated into suckling mice in attempt to isolate virus and to titrate the viremia level. Serological surveys were carried out by using the IgM Antibodies Capture Enzyme Linked Immunosorbent Assay (MAC-ELISA), Complement Fixation (CF), Hemagglulinalion Inhibition (HI) and Neutralization (N) tests. The yellow fever virus, recovered from the two first samples and the virus titration, showed high level of viremia. After that, specific antibodies appeared in all samples. The interval between the end of the viremia and the appearance of the antibodies was associated with the worsening of clinical symptoms, including bleeding of the mucous membrane. One must be aware of the risk of having a urban epidemics in areas where Aedes aegypti is found in high infestation indexes. Os autores estudaram um caso humano de febre amarela silvestre, sob os aspectos clínico, laboratorial e epidemiológico. O paciente apresentava febre (39ºC), calafrios, sudorese, cefaléia, dor lombar, mialgia, dor abdominal em epigástrio, náuseas, vômitos, diarréia e prostração. Relatava permanência em área onde foram constatados casos de febre amarela silvestre e não havia histórico de vacinação anterior. Frente às suspeitas que levaram à investigação do vírus da febre amarela, foram colhidas várias amostras de sangue no curso da doença. As amostras do 5º, 7º e 10º dias foram submetidas a provas de isolamento e quantificação do vírus, o que possibilitou o estudo da viremia. Empregando-se os testes de MAC-ELISA (detecção de IgM), Fixação de Complemento (FC), Inibição de Hemaglutinação (IH) e teste de Neutralização (N), foi observada a resposta imune para anticorpos específicos nas amostras do 7º ao 26º dias. Os resultados mostraram que no 5º e 7º dias havia persistência da fase virêmica, com títulos elevados. Ao término desta fase, com o aparecimento de anticorpos específicos, foi observado um agravamento do quadro clínico, com sangramento de mucosas. Os autores alertam para a possibilidade de ocorrerem epidemias urbanas em áreas com alta infestação de Aedes aegypti. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1995-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29286Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 4 (1995); 337-341 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 4 (1995); 337-341 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 4 (1995); 337-341 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29286/31143Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessNassar, Elza da S.Chamelet, Esther L. B.Coimbra, Terezinha L. M.Souza, Luiza T. M. deSuzuki, AkemiFerreira, Ivani B.Silva, Marcos V. daRocco, Iray M.Rosa, Amélia P. A. Travassos da2012-07-02T01:40:33Zoai:revistas.usp.br:article/29286Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:02.091764Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case Febre amarela silvestre: estudo clínico e laboratorial, enfatizando a viremia, de um caso humano |
title |
Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case |
spellingShingle |
Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case Nassar, Elza da S. Arbovirus Jungle yellow fever Viremia Clinical and laboratorial diagnosis |
title_short |
Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case |
title_full |
Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case |
title_fullStr |
Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case |
title_full_unstemmed |
Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case |
title_sort |
Jungle yellow fever: clinical and laboratorial sudies emphasizing viremia on a human case |
author |
Nassar, Elza da S. |
author_facet |
Nassar, Elza da S. Chamelet, Esther L. B. Coimbra, Terezinha L. M. Souza, Luiza T. M. de Suzuki, Akemi Ferreira, Ivani B. Silva, Marcos V. da Rocco, Iray M. Rosa, Amélia P. A. Travassos da |
author_role |
author |
author2 |
Chamelet, Esther L. B. Coimbra, Terezinha L. M. Souza, Luiza T. M. de Suzuki, Akemi Ferreira, Ivani B. Silva, Marcos V. da Rocco, Iray M. Rosa, Amélia P. A. Travassos da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nassar, Elza da S. Chamelet, Esther L. B. Coimbra, Terezinha L. M. Souza, Luiza T. M. de Suzuki, Akemi Ferreira, Ivani B. Silva, Marcos V. da Rocco, Iray M. Rosa, Amélia P. A. Travassos da |
dc.subject.por.fl_str_mv |
Arbovirus Jungle yellow fever Viremia Clinical and laboratorial diagnosis |
topic |
Arbovirus Jungle yellow fever Viremia Clinical and laboratorial diagnosis |
description |
The authors report the clinical, laboratorial and epidemiological aspects of a human case of jungle yellow fever. The patient suffered from fever, chills, sweating, headaches, backaches, myalgia, epigastric pains, nausea, vomiting, diarrhea and prostration. He was unvaccinated and had been working in areas where cases of jungle yellow fever had been confirmed. Investigations concerning the yellow fever virus were performed. Blood samples were collected on several days in the course of the illness. Three of these samples (those obtained on days 5,7 and 10) were inoculated into suckling mice in attempt to isolate virus and to titrate the viremia level. Serological surveys were carried out by using the IgM Antibodies Capture Enzyme Linked Immunosorbent Assay (MAC-ELISA), Complement Fixation (CF), Hemagglulinalion Inhibition (HI) and Neutralization (N) tests. The yellow fever virus, recovered from the two first samples and the virus titration, showed high level of viremia. After that, specific antibodies appeared in all samples. The interval between the end of the viremia and the appearance of the antibodies was associated with the worsening of clinical symptoms, including bleeding of the mucous membrane. One must be aware of the risk of having a urban epidemics in areas where Aedes aegypti is found in high infestation indexes. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29286 |
url |
https://www.revistas.usp.br/rimtsp/article/view/29286 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29286/31143 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 4 (1995); 337-341 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 4 (1995); 337-341 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 4 (1995); 337-341 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951641628540928 |