Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis

Detalhes bibliográficos
Autor(a) principal: Miranda, Luisa Helena Monteiro de
Data de Publicação: 2018
Outros Autores: Meli, Marina, Silva, Fátima Conceição, Novacco, Marilisa, Menezes, Rodrigo Caldas, Pereira, Sandro Antonio, Sugiarto, Sarah, Reis, Érica Guerino dos, Gremião, Isabella Dib Ferreira, Hofmann-Lehmann, Regina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31683
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / University of Zurich. Vetsuisse Faculty. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland.
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spelling Miranda, Luisa Helena Monteiro deMeli, MarinaSilva, Fátima ConceiçãoNovacco, MarilisaMenezes, Rodrigo CaldasPereira, Sandro AntonioSugiarto, SarahReis, Érica Guerino dosGremião, Isabella Dib FerreiraHofmann-Lehmann, Regina2019-02-15T16:14:14Z2019-02-15T16:14:14Z2018MIRANDA, Luisa Helena Monteiro de et al. Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis. Plos One, v. 13, n. 11, p. 1-16, Nov. 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/3168310.1371/journal.pone.0207644engPublic Library of ScienceEsporotricoseCo-infecçãoParâmetros imunológicosGatosRetrovírus felinoCo-infectionFeline retrovirusImmunological parametersSporotrichosisCatsCo-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / University of Zurich. Vetsuisse Faculty. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland.University of Zurich. Vetsuisse Faculty. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.University of Zurich. Vetsuisse Faculty. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Zurich. Vetsuisse Faculty. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Zurich. Vetsuisse Faculty. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland.Feline sporotrichosis due to Sporothrix brasiliensis is frequently severe and often correlated to zoonotic transmission. Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) cause immunodeficiency in cats; no association has been identified with critical cases of sporotrichosis. Moreover, the cytokine profile in Sporothrix-infected cats and a potential impact of retrovirus co-infections on their immunity is unknown. This study assessed immunological parameters in cats with sporotrichosis with and without FIV or FeLV co-infection. FeLV infection was detected by antigen ELISA and by provirus PCR. FIV infection was investigated through ELISA and Western blot. Cytokine transcription (IFN-γ, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-α) was quantified using RT-qPCR and lymphocyte subpopulations (CD4, CD8, CD5 and CD21) were assessed by flow cytometry. Thirty cats with sporotrichosis were recruited to the study, including three FIV-positive and five FeLV-positive (progressive infection) cats. One cat with regressive FeLV infection was excluded from statistics. In comparison to retrovirus-negative cats, FIV-positive cats and FeLV-positive cats had higher IL-10 levels, FeLV-positive cats had lower IL-4 levels and FIV-positive cats had lower IL-12 levels and a lower CD4+/CD8+ ratio. Remarkably, all cats with poor general condition were FeLV (progressive infection) or FIV-positive, but the retrovirus status was not associated with the sporotrichosis treatment length or outcome. The immunological changes and the more severe clinical presentation observed in cats with retrovirus co-infections encourage future prospective studies that address the impact of these changes on prognostic determinants of feline sporotrichosis and the development of new therapy strategies that control disease spread.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31683/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfatimaconceição_silva_etal_IOC_2018.pdffatimaconceição_silva_etal_IOC_2018.pdfapplication/pdf866903https://www.arca.fiocruz.br/bitstream/icict/31683/2/fatimaconcei%c3%a7%c3%a3o_silva_etal_IOC_2018.pdf096339948b8f53e5de6069ffe76bd719MD52TEXTfatimaconceição_silva_etal_IOC_2018.pdf.txtfatimaconceição_silva_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
title Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
spellingShingle Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
Miranda, Luisa Helena Monteiro de
Esporotricose
Co-infecção
Parâmetros imunológicos
Gatos
Retrovírus felino
Co-infection
Feline retrovirus
Immunological parameters
Sporotrichosis
Cats
title_short Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
title_full Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
title_fullStr Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
title_full_unstemmed Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
title_sort Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis
author Miranda, Luisa Helena Monteiro de
author_facet Miranda, Luisa Helena Monteiro de
Meli, Marina
Silva, Fátima Conceição
Novacco, Marilisa
Menezes, Rodrigo Caldas
Pereira, Sandro Antonio
Sugiarto, Sarah
Reis, Érica Guerino dos
Gremião, Isabella Dib Ferreira
Hofmann-Lehmann, Regina
author_role author
author2 Meli, Marina
Silva, Fátima Conceição
Novacco, Marilisa
Menezes, Rodrigo Caldas
Pereira, Sandro Antonio
Sugiarto, Sarah
Reis, Érica Guerino dos
Gremião, Isabella Dib Ferreira
Hofmann-Lehmann, Regina
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Miranda, Luisa Helena Monteiro de
Meli, Marina
Silva, Fátima Conceição
Novacco, Marilisa
Menezes, Rodrigo Caldas
Pereira, Sandro Antonio
Sugiarto, Sarah
Reis, Érica Guerino dos
Gremião, Isabella Dib Ferreira
Hofmann-Lehmann, Regina
dc.subject.other.pt_BR.fl_str_mv Esporotricose
Co-infecção
Parâmetros imunológicos
Gatos
Retrovírus felino
topic Esporotricose
Co-infecção
Parâmetros imunológicos
Gatos
Retrovírus felino
Co-infection
Feline retrovirus
Immunological parameters
Sporotrichosis
Cats
dc.subject.en.pt_BR.fl_str_mv Co-infection
Feline retrovirus
Immunological parameters
Sporotrichosis
Cats
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / University of Zurich. Vetsuisse Faculty. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-15T16:14:14Z
dc.date.available.fl_str_mv 2019-02-15T16:14:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIRANDA, Luisa Helena Monteiro de et al. Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis. Plos One, v. 13, n. 11, p. 1-16, Nov. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31683
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0207644
identifier_str_mv MIRANDA, Luisa Helena Monteiro de et al. Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis. Plos One, v. 13, n. 11, p. 1-16, Nov. 2018.
1932-6203
10.1371/journal.pone.0207644
url https://www.arca.fiocruz.br/handle/icict/31683
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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