Neurotransmitters Modulate Intrathymic T-cell Development

Detalhes bibliográficos
Autor(a) principal: Francelin, Carolina
Data de Publicação: 2021
Outros Autores: Veneziani, Luciana Peixoto, Farias, Alessandro dos Santos, Cruz, Daniella Arêas Mendes da, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3389/fcell.2021.668067
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49061
Resumo: Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Microbiologia e Imunologia. Laboratório de Pesquisa Autoimune. Campinas, SP, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / University of Alabama at Birmingham. Department of Ophthalmology and Visual Sciences. Birmingham, AL, USA.
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spelling Francelin, CarolinaVeneziani, Luciana PeixotoFarias, Alessandro dos SantosCruz, Daniella Arêas Mendes daSavino, Wilson2021-09-12T19:32:40Z2021-09-12T19:32:40Z2021FRANCELIN, Carolina et al. Neurotransmitters Modulate Intrathymic T-cell Development. Front. Cell Dev. Biol., v. 9, Article 668067, 7 p, Apr. 2021.2296-634Xhttps://www.arca.fiocruz.br/handle/icict/4906110.3389/fcell.2021.668067engFrontiers MediaNeurotransmissoresTimoCélulas epiteliais teímicasDesenvolvimento de células TTimócitosNeurotransmittersThymusThymic epithelial cellsT-cell developmentThymocytesNeurotransmitters Modulate Intrathymic T-cell Developmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Campinas. Instituto de Biologia. Departamento de Genética, Microbiologia e Imunologia. Laboratório de Pesquisa Autoimune. Campinas, SP, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / University of Alabama at Birmingham. Department of Ophthalmology and Visual Sciences. Birmingham, AL, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Microbiologia e Imunologia. Laboratório de Pesquisa Autoimune. Campinas, SP, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / School of Pharmacy and Biomedical Sciences, University of Central Lancashire. Preston, United Kingdom.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o TImo. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.The existence of a crosstalk between the nervous and immune systems is well established. Neurotransmitters can be produced by immune cells, whereas cytokines can be secreted by cells of nervous tissues. Additionally, cells of both systems express the corresponding receptors. Herein, we discuss the thymus as a paradigm for studies on the neuroimmune network. The thymus is a primary lymphoid organ responsible for the maturation of T lymphocytes. Intrathymic T-cell development is mostly controlled by the thymic microenvironment, formed by thymic epithelial cells (TEC), dendritic cells, macrophages, and fibroblasts. Developing thymocytes and microenvironmental cells can be influenced by exogenous and endogenous stimuli; neurotransmitters are among the endogenous molecules. Norepinephrine is secreted at nerve endings in the thymus, but are also produced by thymic cells, being involved in controlling thymocyte death. Thymocytes and TEC express acetylcholine receptors, but the cognate neurotransmitter seems to be produced and released by lymphoid and microenvironmental cells, not by nerve endings. Evidence indicates that, among others, TECs also produce serotonin and dopamine, as well as somatostatin, substance P, vasoactive intestinal peptide (VIP) and the typical pituitary neurohormones, oxytocin and arg-vasopressin. Although functional data of these molecules in the thymus are scarce, they are likely involved in intrathymic T cell development, as exemplified by somatostatin, which inhibits thymocyte proliferation, differentiation, migration and cytokine production. Overall, intrathymic neuroimmune interactions include various neurotransmitters, most of them of non-neuronal origin, and that should be placed as further physiological players in the general process of T-cell development.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49061/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_DanielaCruz_etal_IOC_2021.pdfWilsonSavino_DanielaCruz_etal_IOC_2021.pdfapplication/pdf971767https://www.arca.fiocruz.br/bitstream/icict/49061/2/WilsonSavino_DanielaCruz_etal_IOC_2021.pdf2458ce3c522a417a83ee05201cd5d36fMD52TEXTWilsonSavino_DanielaCruz_etal_IOC_2021.pdf.txtWilsonSavino_DanielaCruz_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Neurotransmitters Modulate Intrathymic T-cell Development
title Neurotransmitters Modulate Intrathymic T-cell Development
spellingShingle Neurotransmitters Modulate Intrathymic T-cell Development
Francelin, Carolina
Neurotransmissores
Timo
Células epiteliais teímicas
Desenvolvimento de células T
Timócitos
Neurotransmitters
Thymus
Thymic epithelial cells
T-cell development
Thymocytes
title_short Neurotransmitters Modulate Intrathymic T-cell Development
title_full Neurotransmitters Modulate Intrathymic T-cell Development
title_fullStr Neurotransmitters Modulate Intrathymic T-cell Development
title_full_unstemmed Neurotransmitters Modulate Intrathymic T-cell Development
title_sort Neurotransmitters Modulate Intrathymic T-cell Development
author Francelin, Carolina
author_facet Francelin, Carolina
Veneziani, Luciana Peixoto
Farias, Alessandro dos Santos
Cruz, Daniella Arêas Mendes da
Savino, Wilson
author_role author
author2 Veneziani, Luciana Peixoto
Farias, Alessandro dos Santos
Cruz, Daniella Arêas Mendes da
Savino, Wilson
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Francelin, Carolina
Veneziani, Luciana Peixoto
Farias, Alessandro dos Santos
Cruz, Daniella Arêas Mendes da
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Neurotransmissores
Timo
Células epiteliais teímicas
Desenvolvimento de células T
Timócitos
topic Neurotransmissores
Timo
Células epiteliais teímicas
Desenvolvimento de células T
Timócitos
Neurotransmitters
Thymus
Thymic epithelial cells
T-cell development
Thymocytes
dc.subject.en.pt_BR.fl_str_mv Neurotransmitters
Thymus
Thymic epithelial cells
T-cell development
Thymocytes
description Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Microbiologia e Imunologia. Laboratório de Pesquisa Autoimune. Campinas, SP, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil / University of Alabama at Birmingham. Department of Ophthalmology and Visual Sciences. Birmingham, AL, USA.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-12T19:32:40Z
dc.date.available.fl_str_mv 2021-09-12T19:32:40Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FRANCELIN, Carolina et al. Neurotransmitters Modulate Intrathymic T-cell Development. Front. Cell Dev. Biol., v. 9, Article 668067, 7 p, Apr. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49061
dc.identifier.issn.pt_BR.fl_str_mv 2296-634X
dc.identifier.doi.none.fl_str_mv 10.3389/fcell.2021.668067
identifier_str_mv FRANCELIN, Carolina et al. Neurotransmitters Modulate Intrathymic T-cell Development. Front. Cell Dev. Biol., v. 9, Article 668067, 7 p, Apr. 2021.
2296-634X
10.3389/fcell.2021.668067
url https://www.arca.fiocruz.br/handle/icict/49061
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/49061/2/WilsonSavino_DanielaCruz_etal_IOC_2021.pdf
https://www.arca.fiocruz.br/bitstream/icict/49061/3/WilsonSavino_DanielaCruz_etal_IOC_2021.pdf.txt
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