Contribution of inflammasome genetics in Plasmodium vivax malaria.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16140 http://dx.doi.org/10.1016/j.meegid.2016.02.038 |
Resumo: | 2021-01-01 |
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Santos, Marina Lima SilvaReis, Edione CristinaBricher, Pamela NithziSousa, Taís Nóbrega deBrito, Cristiana Ferreira Alves deLacerda, Marcus Vinicius Guimaraes deFontes, Cor Jesus FernandesCarvalho, Luzia Helena dePontillo, Alessandra2016-10-06T18:43:22Z2016-10-06T18:43:22Z2016SANTOS, Marina Lima Silva et al. Contribution of inflammasome genetics in Plasmodium vivax malaria. Infect Genet Evol., v. 40, p. 162-6, 2016.1567-1348https://www.arca.fiocruz.br/handle/icict/16140http://dx.doi.org/10.1016/j.meegid.2016.02.038engElsevier B.V.P. vivaxMalariaInflammasomeNLRP1NLRP3IL1BIL18P. vivaxContribution of inflammasome genetics in Plasmodium vivax malaria.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-01-01Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. Laboratório de Imunogenética. São Paulo, SP, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. Laboratório de Imunogenética. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto de Pesquisas Leônidas and Maria Deane. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, BrasilUniversidade Federal de Mato Grosso. Hospital Julio Muller. Cuiabá, MT, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. Laboratório de Imunogenética. São Paulo, SP, BrasilRecent reports showed that, in mice, symptomatic Plasmodium infection triggers NLRP3/NLRP12-dependent inflammasome formation and caspase-1 activation in monocytes. In humans, few works demonstrated that inflammasome is activated in malaria. As Plasmodium vivax is a potent inducer of inflammatory response we hypothesised that inflammasome genetics might affect P. vivax malaria clinical presentation. For this purpose, selected SNPs in inflammasome genes were analysed among patients with symptomatic P. vivax malaria. 157 Brazilian Amazon patients with P. vivax malaria were genotyped for 10 single nucleotide polymorphisms (SNPs) in inflammasome genes NLRP1, NLRP3, AIM2, CARD8, IL1B, IL18 and MEFV. Effect of SNPs on hematologic and clinical parameters was analysed by multivariate analysis. Our data suggested an important role of NLRP1 inflammasome receptor in shaping the clinical presentation of P. vivax malaria, in termof presence of fever, anaemia and thrombocytopenia. Moreover IL1B rs1143634 resultedsignificantly associated to patients' parasitaemia, while IL18 rs5744256 plays a protective role against the development of anaemia. Polymorphisms in inflammasome genes could affect one or other aspects of malaria pathogenesis. Moreover, these data reveal novel aspects of P. vivax/host interaction that involved NLRP1-inflammasome.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16140/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Santos_Marina_Contribution_CPqRR_2016.pdfve_Santos_Marina_Contribution_CPqRR_2016.pdfapplication/pdf433097https://www.arca.fiocruz.br/bitstream/icict/16140/2/ve_Santos_Marina_Contribution_CPqRR_2016.pdf66afa81acb8cb5bd540acfe6a3eb4b3eMD52TEXTve_Santos_Marina_Contribution_CPqRR_2016.pdf.txtve_Santos_Marina_Contribution_CPqRR_2016.pdf.txtExtracted texttext/plain30946https://www.arca.fiocruz.br/bitstream/icict/16140/3/ve_Santos_Marina_Contribution_CPqRR_2016.pdf.txtb805c3bd9e3072449b6f9da60e9ebfc2MD53icict/161402021-03-24 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| dc.title.pt_BR.fl_str_mv |
Contribution of inflammasome genetics in Plasmodium vivax malaria. |
| title |
Contribution of inflammasome genetics in Plasmodium vivax malaria. |
| spellingShingle |
Contribution of inflammasome genetics in Plasmodium vivax malaria. Santos, Marina Lima Silva P. vivax Malaria Inflammasome NLRP1 NLRP3 IL1B IL18 P. vivax |
| title_short |
Contribution of inflammasome genetics in Plasmodium vivax malaria. |
| title_full |
Contribution of inflammasome genetics in Plasmodium vivax malaria. |
| title_fullStr |
Contribution of inflammasome genetics in Plasmodium vivax malaria. |
| title_full_unstemmed |
Contribution of inflammasome genetics in Plasmodium vivax malaria. |
| title_sort |
Contribution of inflammasome genetics in Plasmodium vivax malaria. |
| author |
Santos, Marina Lima Silva |
| author_facet |
Santos, Marina Lima Silva Reis, Edione Cristina Bricher, Pamela Nithzi Sousa, Taís Nóbrega de Brito, Cristiana Ferreira Alves de Lacerda, Marcus Vinicius Guimaraes de Fontes, Cor Jesus Fernandes Carvalho, Luzia Helena de Pontillo, Alessandra |
| author_role |
author |
| author2 |
Reis, Edione Cristina Bricher, Pamela Nithzi Sousa, Taís Nóbrega de Brito, Cristiana Ferreira Alves de Lacerda, Marcus Vinicius Guimaraes de Fontes, Cor Jesus Fernandes Carvalho, Luzia Helena de Pontillo, Alessandra |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Marina Lima Silva Reis, Edione Cristina Bricher, Pamela Nithzi Sousa, Taís Nóbrega de Brito, Cristiana Ferreira Alves de Lacerda, Marcus Vinicius Guimaraes de Fontes, Cor Jesus Fernandes Carvalho, Luzia Helena de Pontillo, Alessandra |
| dc.subject.other.pt_BR.fl_str_mv |
P. vivax Malaria |
| topic |
P. vivax Malaria Inflammasome NLRP1 NLRP3 IL1B IL18 P. vivax |
| dc.subject.en.pt_BR.fl_str_mv |
Inflammasome NLRP1 NLRP3 IL1B IL18 P. vivax |
| description |
2021-01-01 |
| publishDate |
2016 |
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2016-10-06T18:43:22Z |
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2016-10-06T18:43:22Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SANTOS, Marina Lima Silva et al. Contribution of inflammasome genetics in Plasmodium vivax malaria. Infect Genet Evol., v. 40, p. 162-6, 2016. |
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https://www.arca.fiocruz.br/handle/icict/16140 |
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1567-1348 |
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http://dx.doi.org/10.1016/j.meegid.2016.02.038 |
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SANTOS, Marina Lima Silva et al. Contribution of inflammasome genetics in Plasmodium vivax malaria. Infect Genet Evol., v. 40, p. 162-6, 2016. 1567-1348 |
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https://www.arca.fiocruz.br/handle/icict/16140 http://dx.doi.org/10.1016/j.meegid.2016.02.038 |
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Elsevier B.V. |
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Elsevier B.V. |
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