Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli
| Autor(a) principal: | |
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| Data de Publicação: | 2015 |
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| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9850 |
Resumo: | Universidade Federal de Santa Catarina. Florianopolis, SC, Brazil |
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Stoco, Patrícia HermesWagner, GlauberTalavera-Lopez, CarlosGerber, AlexandraZaha, ArnaldoThompson, Claudia ElizabethBartholomeu, Daniella CastanheiraLuckemeyer, Debora DenardinBahia, DianaLoreto, ElgionPrestes, Elisa BeatrizLima, Fabio MitsuoRodrigues Luiz, GabrielaVallejo, Gustavo AdolfoSilveira Filho, Jose Franco daSchenkman, SergioMonteiro, Karina MarianteTyler, Kevin MorrisAlmeida, Luiz Gonzaga Paula deOrtiz, Mauro FreitasChiurillo, Miguel AngelMoraes, Milene Hoehr deCunha, Oberdan de LimaMendonça Neto, RondonSilva, RosaneTeixeira, Santuza Maria RibeiroMurta, Silvane Maria FonsecaSincero, Thais Cristine MarquesMendes, Tiago Antonio de OliveiraUrmenyi, Turan PeterSilva, Viviane GrazielleRocha, Wanderson Duarte DaAndersson, BjornRomanha, Alvaro JoseSteindel, MarioVasconcelos, Ana Tereza Ribeiro deGrisard, Edmundo Carlos2015-03-27T12:45:23Z2015-03-27T12:45:23Z2015STOCO, Patrıcia Hermes et al. Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli. PLoS Negl Trop Dis, v. 8, n. 9, p. e3176.1553-7366https://www.arca.fiocruz.br/handle/icict/9850Public Library of ScienceengPublic Library of ScienceGenome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeliinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Santa Catarina. Florianopolis, SC, BrazilUniversidade Federal de Santa Catarina. Florianopolis, SC, Brazil/Universidade do Oeste de Santa Catarina. Joaçaba, SC, BrazilKarolinska Institutet. Science for Life Laboratory. Department of Cell and Molecular Biology. Stockholm, SwedenLaboratorio Nacional de Computação Cientıfica. Petropolis, Rio de Janeiro, BrazilUniversidade Federal do Rio Grande do Sul. Porto Alegre, RG, BrazilLaboratorio Nacional de Computação Cientıfica. Petropolis, Rio de Janeiro, BrazilUniversidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversidade Federal de Santa Catarina. Florianopolis, SC, BrazilUniversidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, BrazilUniversidade Federal de Santa Maria. Santa Maria, RG, BrazilUniversidade Federal de Santa Catarina. Florianopolis, SC, BrazilUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, BrazilUniversidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversidad del Tolima. Ibague, ColombiaUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, BrazilUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, BrazilUniversidade Federal do Rio Grande do Sul. Porto Alegre, RG, BrazilUniversidad Centroccidental Lisandro Alvarado. Barquisimeto, VenezuelaLaboratorio Nacional de Computação Cientıfica. Petropolis, Rio de Janeiro, BrazilUniversidade Federal do Rio Grande do Sul. Porto Alegre, RG, BrazilUniversidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brazil/ Universidad Centroccidental Lisandro Alvarado. Barquisimeto, VenezuelaUniversidade Federal de Santa Catarina. Florianopolis, SC, BrazilLaboratorio Nacional de Computação Cientıfica. Petropolis, RJ, BrazilUniversidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, BrazilUniversidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Santa Catarina. Florianopolis, SC, BrazilUniversidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, BrazilUniversidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversidade Federal do Parana. Curitiba, PR, BrazilKarolinska Institutet. Science for Life Laboratory. Department of Cell and Molecular Biology. Stockholm, SwedenUniversidade Federal de Santa Catarina. Florianopolis, SC, BrazilUniversidade Federal de Santa Catarina. Florianopolis, SC, BrazilKarolinska Institutet. Science for Life Laboratory. Department of Cell and Molecular Biology. Stockholm, SwedenUniversidade Federal de Santa Catarina. Florianopolis, SC, BrazilBACKGROUND:Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T. rangeli genome to provide new tools for elucidating the distinct and intriguing biology of this species and the key pathways related to interaction with its arthropod and mammalian hosts. METHODOLOGY/PRINCIPAL FINDINGS:The T. rangeli haploid genome is ∼ 24 Mb in length, and is the smallest and least repetitive trypanosomatid genome sequenced thus far. This parasite genome has shorter subtelomeric sequences compared to those of T. cruzi and T. brucei; displays intraspecific karyotype variability and lacks minichromosomes. Of the predicted 7,613 protein coding sequences, functional annotations could be determined for 2,415, while 5,043 are hypothetical proteins, some with evidence of protein expression. 7,101 genes (93%) are shared with other trypanosomatids that infect humans. An ortholog of the dcl2 gene involved in the T. brucei RNAi pathway was found in T. rangeli, but the RNAi machinery is non-functional since the other genes in this pathway are pseudogenized. T. rangeli is highly susceptible to oxidative stress, a phenotype that may be explained by a smaller number of anti-oxidant defense enzymes and heat-shock proteins. CONCLUSIONS/SIGNIFICANCE: Phylogenetic comparison of nuclear and mitochondrial genes indicates that T. rangeli and T. cruzi are equidistant from T. brucei. In addition to revealing new aspects of trypanosome co-evolution within the vertebrate and invertebrate hosts, comparative genomic analysis with pathogenic trypanosomatids provides valuable new information that can be further explored with the aim of developing better diagnostic tools and/or therapeutic targets.Trypanosoma rangeliChagas diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9850/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINAL2014_177.pdf2014_177.pdfapplication/pdf3180424https://www.arca.fiocruz.br/bitstream/icict/9850/2/2014_177.pdf7769f99cd7cb83158ea45af845da3d4cMD52TEXT2014_177.pdf.txt2014_177.pdf.txtExtracted texttext/plain104658https://www.arca.fiocruz.br/bitstream/icict/9850/3/2014_177.pdf.txt8d9a37dc9ee38533355bda57b0378756MD53icict/98502019-06-19 10:13:16.932oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:13:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli |
| title |
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli |
| spellingShingle |
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli Stoco, Patrícia Hermes Trypanosoma rangeli Chagas disease |
| title_short |
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli |
| title_full |
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli |
| title_fullStr |
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli |
| title_full_unstemmed |
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli |
| title_sort |
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli |
| author |
Stoco, Patrícia Hermes |
| author_facet |
Stoco, Patrícia Hermes Wagner, Glauber Talavera-Lopez, Carlos Gerber, Alexandra Zaha, Arnaldo Thompson, Claudia Elizabeth Bartholomeu, Daniella Castanheira Luckemeyer, Debora Denardin Bahia, Diana Loreto, Elgion Prestes, Elisa Beatriz Lima, Fabio Mitsuo Rodrigues Luiz, Gabriela Vallejo, Gustavo Adolfo Silveira Filho, Jose Franco da Schenkman, Sergio Monteiro, Karina Mariante Tyler, Kevin Morris Almeida, Luiz Gonzaga Paula de Ortiz, Mauro Freitas Chiurillo, Miguel Angel Moraes, Milene Hoehr de Cunha, Oberdan de Lima Mendonça Neto, Rondon Silva, Rosane Teixeira, Santuza Maria Ribeiro Murta, Silvane Maria Fonseca Sincero, Thais Cristine Marques Mendes, Tiago Antonio de Oliveira Urmenyi, Turan Peter Silva, Viviane Grazielle Rocha, Wanderson Duarte Da Andersson, Bjorn Romanha, Alvaro Jose Steindel, Mario Vasconcelos, Ana Tereza Ribeiro de Grisard, Edmundo Carlos |
| author_role |
author |
| author2 |
Wagner, Glauber Talavera-Lopez, Carlos Gerber, Alexandra Zaha, Arnaldo Thompson, Claudia Elizabeth Bartholomeu, Daniella Castanheira Luckemeyer, Debora Denardin Bahia, Diana Loreto, Elgion Prestes, Elisa Beatriz Lima, Fabio Mitsuo Rodrigues Luiz, Gabriela Vallejo, Gustavo Adolfo Silveira Filho, Jose Franco da Schenkman, Sergio Monteiro, Karina Mariante Tyler, Kevin Morris Almeida, Luiz Gonzaga Paula de Ortiz, Mauro Freitas Chiurillo, Miguel Angel Moraes, Milene Hoehr de Cunha, Oberdan de Lima Mendonça Neto, Rondon Silva, Rosane Teixeira, Santuza Maria Ribeiro Murta, Silvane Maria Fonseca Sincero, Thais Cristine Marques Mendes, Tiago Antonio de Oliveira Urmenyi, Turan Peter Silva, Viviane Grazielle Rocha, Wanderson Duarte Da Andersson, Bjorn Romanha, Alvaro Jose Steindel, Mario Vasconcelos, Ana Tereza Ribeiro de Grisard, Edmundo Carlos |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
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Stoco, Patrícia Hermes Wagner, Glauber Talavera-Lopez, Carlos Gerber, Alexandra Zaha, Arnaldo Thompson, Claudia Elizabeth Bartholomeu, Daniella Castanheira Luckemeyer, Debora Denardin Bahia, Diana Loreto, Elgion Prestes, Elisa Beatriz Lima, Fabio Mitsuo Rodrigues Luiz, Gabriela Vallejo, Gustavo Adolfo Silveira Filho, Jose Franco da Schenkman, Sergio Monteiro, Karina Mariante Tyler, Kevin Morris Almeida, Luiz Gonzaga Paula de Ortiz, Mauro Freitas Chiurillo, Miguel Angel Moraes, Milene Hoehr de Cunha, Oberdan de Lima Mendonça Neto, Rondon Silva, Rosane Teixeira, Santuza Maria Ribeiro Murta, Silvane Maria Fonseca Sincero, Thais Cristine Marques Mendes, Tiago Antonio de Oliveira Urmenyi, Turan Peter Silva, Viviane Grazielle Rocha, Wanderson Duarte Da Andersson, Bjorn Romanha, Alvaro Jose Steindel, Mario Vasconcelos, Ana Tereza Ribeiro de Grisard, Edmundo Carlos |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma rangeli Chagas disease |
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Trypanosoma rangeli Chagas disease |
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Universidade Federal de Santa Catarina. Florianopolis, SC, Brazil |
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2015 |
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2015 |
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STOCO, Patrıcia Hermes et al. Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli. PLoS Negl Trop Dis, v. 8, n. 9, p. e3176. |
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1553-7366 |
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Public Library of Science |
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STOCO, Patrıcia Hermes et al. Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli. PLoS Negl Trop Dis, v. 8, n. 9, p. e3176. 1553-7366 Public Library of Science |
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