The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8133 |
Resumo: | Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium. |
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Van Dooren, SoniaPybus, Oliver G.Salemi, MarcoLiu, Hong-FeiGoubau, P.Remondegui, CarloTalarmin, AntoineGotuzzo, EduardoAlcantara, Luiz Carlos JúniorCastro Filho, Bernardo GalvãoVandamme, Anne-Mieke2014-08-05T16:59:33Z2014-08-05T16:59:33Z2004VAN DOOREN, S. et al. The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains. Molecular Biology and Evolution, v. 21, n. 3, p. 603-611, 2004.0737-4038https://www.arca.fiocruz.br/handle/icict/813310.1093/molbev/msh053engOxford University PressThe low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.University of Oxford. Department of Zoology. Oxford, U.K.Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.Department of Medical Research. Mackay Memorial Hospital. Taipei, Taiwan.Universite´ Catholique de Louvain. Unité de Virologie. Bruxelles, Belgium.Hospital San Roque. San Salvador de Jujuy, Argentina.Institut Pasteur de la Guyane. Laboratoire de Rétrovirologie. Cayenne, French Guiana.Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander Von Humboldt. Lima, Peru.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasil.Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.The evolutionary rate of the human T-cell lymphotropic virus type-1 (HTLV-1) is considered to be very low, in strong contrast to the related human retrovirus HIV. However, current estimates of the HTLV-1 rate rely on the anthropological calibration of phylogenies using assumed dates of human migration events. To obtain an independent rate estimate, we analyzed two variable regions of the HTLV-1 genome (LTR and env) from eight infected families. Remarkable genetic stability was observed, as only two mutations in LTR (756 bp) and three mutations in env (522 bp) occurred within the 16 vertical transmission chains, including one ambiguous position in each region. The evolutionary rate in HTLV-1 was then calculated using a maximum-likelihood approach that used the highest and lowest possible times of HTLV-1 shared ancestry, given the known transmission histories. The rates for the LTR and env regions were 9.58 3 10 8–1.25 3 10 5 and 7.84310 7 –2.33310 5nucleotide substitutions per site per year, respectively. A more precise estimate was obtained for the combined LTR-env data set, which was 7.06310 7–1.38310 5substitutions per site per year. We also note an interesting correlation between the occurrence of mutations in HTLV-1 and the age of the individual infected.HTLV-1Vertical transmissionEvolutionary rateMolecular clockEvolução BiológicaVírus 1 Linfotrópico T Humano/genéticaTransmissão Vertical de Doença InfecciosaAdolescenteAdultoIdosoCriançaPré-EscolarFemininoInfecções por HTLV-I/transmissãoHumanosFunções VerossimilhançaMasculinoMeia-IdadeMutaçãoLinhagemFilogeniaDistribuição de Poissoninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALVan Dooren S The low evolutionary....pdfVan Dooren S The low evolutionary....pdfapplication/pdf419430https://www.arca.fiocruz.br/bitstream/icict/8133/1/Van%20Dooren%20S%20The%20low%20evolutionary....pdf60cf458b0128851a14a4167dbd33fcc9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8133/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTVan Dooren S The low evolutionary....pdf.txtVan Dooren S The low evolutionary....pdf.txtExtracted texttext/plain40058https://www.arca.fiocruz.br/bitstream/icict/8133/3/Van%20Dooren%20S%20The%20low%20evolutionary....pdf.txtf85ef274b20c707bd486ff5c224e908eMD53icict/81332023-03-15 14:34:12.107oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains |
| title |
The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains |
| spellingShingle |
The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains Van Dooren, Sonia HTLV-1 Vertical transmission Evolutionary rate Molecular clock Evolução Biológica Vírus 1 Linfotrópico T Humano/genética Transmissão Vertical de Doença Infecciosa Adolescente Adulto Idoso Criança Pré-Escolar Feminino Infecções por HTLV-I/transmissão Humanos Funções Verossimilhança Masculino Meia-Idade Mutação Linhagem Filogenia Distribuição de Poisson |
| title_short |
The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains |
| title_full |
The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains |
| title_fullStr |
The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains |
| title_full_unstemmed |
The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains |
| title_sort |
The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains |
| author |
Van Dooren, Sonia |
| author_facet |
Van Dooren, Sonia Pybus, Oliver G. Salemi, Marco Liu, Hong-Fei Goubau, P. Remondegui, Carlo Talarmin, Antoine Gotuzzo, Eduardo Alcantara, Luiz Carlos Júnior Castro Filho, Bernardo Galvão Vandamme, Anne-Mieke |
| author_role |
author |
| author2 |
Pybus, Oliver G. Salemi, Marco Liu, Hong-Fei Goubau, P. Remondegui, Carlo Talarmin, Antoine Gotuzzo, Eduardo Alcantara, Luiz Carlos Júnior Castro Filho, Bernardo Galvão Vandamme, Anne-Mieke |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Van Dooren, Sonia Pybus, Oliver G. Salemi, Marco Liu, Hong-Fei Goubau, P. Remondegui, Carlo Talarmin, Antoine Gotuzzo, Eduardo Alcantara, Luiz Carlos Júnior Castro Filho, Bernardo Galvão Vandamme, Anne-Mieke |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1 Vertical transmission Evolutionary rate Molecular clock |
| topic |
HTLV-1 Vertical transmission Evolutionary rate Molecular clock Evolução Biológica Vírus 1 Linfotrópico T Humano/genética Transmissão Vertical de Doença Infecciosa Adolescente Adulto Idoso Criança Pré-Escolar Feminino Infecções por HTLV-I/transmissão Humanos Funções Verossimilhança Masculino Meia-Idade Mutação Linhagem Filogenia Distribuição de Poisson |
| dc.subject.decs.pt_BR.fl_str_mv |
Evolução Biológica Vírus 1 Linfotrópico T Humano/genética Transmissão Vertical de Doença Infecciosa Adolescente Adulto Idoso Criança Pré-Escolar Feminino Infecções por HTLV-I/transmissão Humanos Funções Verossimilhança Masculino Meia-Idade Mutação Linhagem Filogenia Distribuição de Poisson |
| description |
Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium. |
| publishDate |
2004 |
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2004 |
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2014-08-05T16:59:33Z |
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2014-08-05T16:59:33Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
VAN DOOREN, S. et al. The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains. Molecular Biology and Evolution, v. 21, n. 3, p. 603-611, 2004. |
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https://www.arca.fiocruz.br/handle/icict/8133 |
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0737-4038 |
| dc.identifier.doi.none.fl_str_mv |
10.1093/molbev/msh053 |
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VAN DOOREN, S. et al. The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains. Molecular Biology and Evolution, v. 21, n. 3, p. 603-611, 2004. 0737-4038 10.1093/molbev/msh053 |
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Oxford University Press |
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Oxford University Press |
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