The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains

Detalhes bibliográficos
Autor(a) principal: Van Dooren, Sonia
Data de Publicação: 2004
Outros Autores: Pybus, Oliver G., Salemi, Marco, Liu, Hong-Fei, Goubau, P., Remondegui, Carlo, Talarmin, Antoine, Gotuzzo, Eduardo, Alcantara, Luiz Carlos Júnior, Castro Filho, Bernardo Galvão, Vandamme, Anne-Mieke
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8133
Resumo: Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.
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spelling Van Dooren, SoniaPybus, Oliver G.Salemi, MarcoLiu, Hong-FeiGoubau, P.Remondegui, CarloTalarmin, AntoineGotuzzo, EduardoAlcantara, Luiz Carlos JúniorCastro Filho, Bernardo GalvãoVandamme, Anne-Mieke2014-08-05T16:59:33Z2014-08-05T16:59:33Z2004VAN DOOREN, S. et al. The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains. Molecular Biology and Evolution, v. 21, n. 3, p. 603-611, 2004.0737-4038https://www.arca.fiocruz.br/handle/icict/813310.1093/molbev/msh053engOxford University PressThe low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.University of Oxford. Department of Zoology. Oxford, U.K.Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.Department of Medical Research. Mackay Memorial Hospital. Taipei, Taiwan.Universite´ Catholique de Louvain. Unité de Virologie. Bruxelles, Belgium.Hospital San Roque. San Salvador de Jujuy, Argentina.Institut Pasteur de la Guyane. Laboratoire de Rétrovirologie. Cayenne, French Guiana.Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander Von Humboldt. Lima, Peru.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasil.Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.The evolutionary rate of the human T-cell lymphotropic virus type-1 (HTLV-1) is considered to be very low, in strong contrast to the related human retrovirus HIV. However, current estimates of the HTLV-1 rate rely on the anthropological calibration of phylogenies using assumed dates of human migration events. To obtain an independent rate estimate, we analyzed two variable regions of the HTLV-1 genome (LTR and env) from eight infected families. Remarkable genetic stability was observed, as only two mutations in LTR (756 bp) and three mutations in env (522 bp) occurred within the 16 vertical transmission chains, including one ambiguous position in each region. The evolutionary rate in HTLV-1 was then calculated using a maximum-likelihood approach that used the highest and lowest possible times of HTLV-1 shared ancestry, given the known transmission histories. The rates for the LTR and env regions were 9.58 3 10 8–1.25 3 10 5 and 7.84310 7 –2.33310 5nucleotide substitutions per site per year, respectively. A more precise estimate was obtained for the combined LTR-env data set, which was 7.06310 7–1.38310 5substitutions per site per year. We also note an interesting correlation between the occurrence of mutations in HTLV-1 and the age of the individual infected.HTLV-1Vertical transmissionEvolutionary rateMolecular clockEvolução BiológicaVírus 1 Linfotrópico T Humano/genéticaTransmissão Vertical de Doença InfecciosaAdolescenteAdultoIdosoCriançaPré-EscolarFemininoInfecções por HTLV-I/transmissãoHumanosFunções VerossimilhançaMasculinoMeia-IdadeMutaçãoLinhagemFilogeniaDistribuição de Poissoninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALVan Dooren S The low evolutionary....pdfVan Dooren S The low evolutionary....pdfapplication/pdf419430https://www.arca.fiocruz.br/bitstream/icict/8133/1/Van%20Dooren%20S%20The%20low%20evolutionary....pdf60cf458b0128851a14a4167dbd33fcc9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8133/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTVan Dooren S The low evolutionary....pdf.txtVan Dooren S The low evolutionary....pdf.txtExtracted texttext/plain40058https://www.arca.fiocruz.br/bitstream/icict/8133/3/Van%20Dooren%20S%20The%20low%20evolutionary....pdf.txtf85ef274b20c707bd486ff5c224e908eMD53icict/81332023-03-15 14:34:12.107oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
title The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
spellingShingle The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
Van Dooren, Sonia
HTLV-1
Vertical transmission
Evolutionary rate
Molecular clock
Evolução Biológica
Vírus 1 Linfotrópico T Humano/genética
Transmissão Vertical de Doença Infecciosa
Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Infecções por HTLV-I/transmissão
Humanos
Funções Verossimilhança
Masculino
Meia-Idade
Mutação
Linhagem
Filogenia
Distribuição de Poisson
title_short The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
title_full The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
title_fullStr The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
title_full_unstemmed The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
title_sort The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
author Van Dooren, Sonia
author_facet Van Dooren, Sonia
Pybus, Oliver G.
Salemi, Marco
Liu, Hong-Fei
Goubau, P.
Remondegui, Carlo
Talarmin, Antoine
Gotuzzo, Eduardo
Alcantara, Luiz Carlos Júnior
Castro Filho, Bernardo Galvão
Vandamme, Anne-Mieke
author_role author
author2 Pybus, Oliver G.
Salemi, Marco
Liu, Hong-Fei
Goubau, P.
Remondegui, Carlo
Talarmin, Antoine
Gotuzzo, Eduardo
Alcantara, Luiz Carlos Júnior
Castro Filho, Bernardo Galvão
Vandamme, Anne-Mieke
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Van Dooren, Sonia
Pybus, Oliver G.
Salemi, Marco
Liu, Hong-Fei
Goubau, P.
Remondegui, Carlo
Talarmin, Antoine
Gotuzzo, Eduardo
Alcantara, Luiz Carlos Júnior
Castro Filho, Bernardo Galvão
Vandamme, Anne-Mieke
dc.subject.en.pt_BR.fl_str_mv HTLV-1
Vertical transmission
Evolutionary rate
Molecular clock
topic HTLV-1
Vertical transmission
Evolutionary rate
Molecular clock
Evolução Biológica
Vírus 1 Linfotrópico T Humano/genética
Transmissão Vertical de Doença Infecciosa
Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Infecções por HTLV-I/transmissão
Humanos
Funções Verossimilhança
Masculino
Meia-Idade
Mutação
Linhagem
Filogenia
Distribuição de Poisson
dc.subject.decs.pt_BR.fl_str_mv Evolução Biológica
Vírus 1 Linfotrópico T Humano/genética
Transmissão Vertical de Doença Infecciosa
Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Infecções por HTLV-I/transmissão
Humanos
Funções Verossimilhança
Masculino
Meia-Idade
Mutação
Linhagem
Filogenia
Distribuição de Poisson
description Rega Institute for Medical Research. Katholieke Universiteit Leuven. Leuven, Belgium.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2014-08-05T16:59:33Z
dc.date.available.fl_str_mv 2014-08-05T16:59:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VAN DOOREN, S. et al. The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains. Molecular Biology and Evolution, v. 21, n. 3, p. 603-611, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8133
dc.identifier.issn.none.fl_str_mv 0737-4038
dc.identifier.doi.none.fl_str_mv 10.1093/molbev/msh053
identifier_str_mv VAN DOOREN, S. et al. The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains. Molecular Biology and Evolution, v. 21, n. 3, p. 603-611, 2004.
0737-4038
10.1093/molbev/msh053
url https://www.arca.fiocruz.br/handle/icict/8133
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
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