Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets

Detalhes bibliográficos
Autor(a) principal: Mattos, Rafael Teixeira de
Data de Publicação: 2016
Outros Autores: Medeiros, Nayara Ingrid de, Menezes, Carlos A., Fares, Rafaelle Christine Gomes, Franco, Eliza P., Dutra, Walderez Ornelas, Santos, Fabrıcio Rios, Oliveira, Rodrigo Correa de, Gomes, Juliana Assis Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23647
Resumo: FAPEMIG/CNPq
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spelling Mattos, Rafael Teixeira deMedeiros, Nayara Ingrid deMenezes, Carlos A.Fares, Rafaelle Christine GomesFranco, Eliza P.Dutra, Walderez OrnelasSantos, Fabrıcio RiosOliveira, Rodrigo Correa deGomes, Juliana Assis Silva2017-12-13T16:49:29Z2017-12-13T16:49:29Z2016MATTOS, Rafael Teixeira de et al. Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets. Plos One, v. 11, n. 12, art. e0168610, 20161932-6203https://www.arca.fiocruz.br/handle/icict/2364710.1371/journal.pone.0168610FAPEMIG/CNPqUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilUniversidade Estadual de Santa Cruz. Departamento de Genetica. Ilheus, BA, Brasil/Servico de Medicina Preventiva da Unimed. Aracaju, SE, BrasilFundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, Brasil/ Instituto Nacional de Ciência e Tecnologia em Doencas Tropicais—INCT-DTUniversidade Federal de Mato Grasso. Departamento de Ciências Basicas da Saude. Faculdade de Medicina. Cuiaba, MT, BrasilFundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/ Instituto Nacional de Ciência e Tecnologia em Doencas Tropicais—INCT-DTUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, BrasilChronic low-grade inflammation is related to the development of comorbidities and poor prognosis in obesity. Monocytes are main sources of cytokines and play a pivotal role in inflammation. We evaluated monocyte frequency, phenotype and cytokine profile of monocyte subsets, to determine their association with the pathogenesis of childhood obesity. Children with obesity were evaluated for biochemical and anthropometric parameters. Monocyte subsets were characterized by flow cytometry, considering cytokine production and activation/recognition molecules. Correlation analysis between clinical parameters and immunological data delineated the monocytes contribution for low-grade inflammation. We observed a higher frequency of non-classical monocytes in the childhood obesity group (CO) than normal-weight group (NW). All subsets displayed higher TLR4 expression in CO, but their recognition and antigen presentation functions seem to be diminished due to lower expression of CD40, CD80/86 and HLA-DR. All subsets showed a lower expression of IL-10 in CO and correlation analyses showed changes in IL-10 expression profile. The lower expression of IL-10 may be decisive for the maintenance of the low-grade inflammation status in CO, especially for alterations in non-classical monocytes profile. These cells may contribute to supporting inflammation and loss of regulation in the immune response of children with obesity.engPublic Library of Scienceobesidade infantilresposta imuneMonocytesChildhood obesityInflammationCytokinesObesityInflammatory diseasesAdiponectinImmune responseChronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/23647/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALChronic Low-Grade Inflammation in Childhood Obesity.pdfChronic Low-Grade Inflammation in Childhood Obesity.pdfapplication/pdf7367809https://www.arca.fiocruz.br/bitstream/icict/23647/2/Chronic%20Low-Grade%20Inflammation%20in%20Childhood%20Obesity.pdf7fe44c78117bdbeba3fb468364e5ffbbMD52TEXTChronic Low-Grade Inflammation in Childhood Obesity.pdf.txtChronic Low-Grade Inflammation in Childhood Obesity.pdf.txtExtracted texttext/plain258https://www.arca.fiocruz.br/bitstream/icict/23647/3/Chronic%20Low-Grade%20Inflammation%20in%20Childhood%20Obesity.pdf.txtd0fc7f15c87adac427c803bd54f93e0fMD53icict/236472019-06-19 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dc.title.pt_BR.fl_str_mv Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
title Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
spellingShingle Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
Mattos, Rafael Teixeira de
obesidade infantil
resposta imune
Monocytes
Childhood obesity
Inflammation
Cytokines
Obesity
Inflammatory diseases
Adiponectin
Immune response
title_short Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
title_full Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
title_fullStr Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
title_full_unstemmed Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
title_sort Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
author Mattos, Rafael Teixeira de
author_facet Mattos, Rafael Teixeira de
Medeiros, Nayara Ingrid de
Menezes, Carlos A.
Fares, Rafaelle Christine Gomes
Franco, Eliza P.
Dutra, Walderez Ornelas
Santos, Fabrıcio Rios
Oliveira, Rodrigo Correa de
Gomes, Juliana Assis Silva
author_role author
author2 Medeiros, Nayara Ingrid de
Menezes, Carlos A.
Fares, Rafaelle Christine Gomes
Franco, Eliza P.
Dutra, Walderez Ornelas
Santos, Fabrıcio Rios
Oliveira, Rodrigo Correa de
Gomes, Juliana Assis Silva
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mattos, Rafael Teixeira de
Medeiros, Nayara Ingrid de
Menezes, Carlos A.
Fares, Rafaelle Christine Gomes
Franco, Eliza P.
Dutra, Walderez Ornelas
Santos, Fabrıcio Rios
Oliveira, Rodrigo Correa de
Gomes, Juliana Assis Silva
dc.subject.other.pt_BR.fl_str_mv obesidade infantil
resposta imune
topic obesidade infantil
resposta imune
Monocytes
Childhood obesity
Inflammation
Cytokines
Obesity
Inflammatory diseases
Adiponectin
Immune response
dc.subject.en.pt_BR.fl_str_mv Monocytes
Childhood obesity
Inflammation
Cytokines
Obesity
Inflammatory diseases
Adiponectin
Immune response
description FAPEMIG/CNPq
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-12-13T16:49:29Z
dc.date.available.fl_str_mv 2017-12-13T16:49:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MATTOS, Rafael Teixeira de et al. Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets. Plos One, v. 11, n. 12, art. e0168610, 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23647
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0168610
identifier_str_mv MATTOS, Rafael Teixeira de et al. Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets. Plos One, v. 11, n. 12, art. e0168610, 2016
1932-6203
10.1371/journal.pone.0168610
url https://www.arca.fiocruz.br/handle/icict/23647
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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