Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23647 |
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Mattos, Rafael Teixeira deMedeiros, Nayara Ingrid deMenezes, Carlos A.Fares, Rafaelle Christine GomesFranco, Eliza P.Dutra, Walderez OrnelasSantos, Fabrıcio RiosOliveira, Rodrigo Correa deGomes, Juliana Assis Silva2017-12-13T16:49:29Z2017-12-13T16:49:29Z2016MATTOS, Rafael Teixeira de et al. Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets. Plos One, v. 11, n. 12, art. e0168610, 20161932-6203https://www.arca.fiocruz.br/handle/icict/2364710.1371/journal.pone.0168610FAPEMIG/CNPqUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilUniversidade Estadual de Santa Cruz. Departamento de Genetica. Ilheus, BA, Brasil/Servico de Medicina Preventiva da Unimed. Aracaju, SE, BrasilFundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, Brasil/ Instituto Nacional de Ciência e Tecnologia em Doencas Tropicais—INCT-DTUniversidade Federal de Mato Grasso. Departamento de Ciências Basicas da Saude. Faculdade de Medicina. Cuiaba, MT, BrasilFundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/ Instituto Nacional de Ciência e Tecnologia em Doencas Tropicais—INCT-DTUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morfologia. Laboratorio de Biologia das Interacões Celulares. Belo Horizonte, MG, BrasilChronic low-grade inflammation is related to the development of comorbidities and poor prognosis in obesity. Monocytes are main sources of cytokines and play a pivotal role in inflammation. We evaluated monocyte frequency, phenotype and cytokine profile of monocyte subsets, to determine their association with the pathogenesis of childhood obesity. Children with obesity were evaluated for biochemical and anthropometric parameters. Monocyte subsets were characterized by flow cytometry, considering cytokine production and activation/recognition molecules. Correlation analysis between clinical parameters and immunological data delineated the monocytes contribution for low-grade inflammation. We observed a higher frequency of non-classical monocytes in the childhood obesity group (CO) than normal-weight group (NW). All subsets displayed higher TLR4 expression in CO, but their recognition and antigen presentation functions seem to be diminished due to lower expression of CD40, CD80/86 and HLA-DR. All subsets showed a lower expression of IL-10 in CO and correlation analyses showed changes in IL-10 expression profile. The lower expression of IL-10 may be decisive for the maintenance of the low-grade inflammation status in CO, especially for alterations in non-classical monocytes profile. These cells may contribute to supporting inflammation and loss of regulation in the immune response of children with obesity.engPublic Library of Scienceobesidade infantilresposta imuneMonocytesChildhood obesityInflammationCytokinesObesityInflammatory diseasesAdiponectinImmune responseChronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/23647/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALChronic Low-Grade Inflammation in Childhood Obesity.pdfChronic Low-Grade Inflammation in Childhood Obesity.pdfapplication/pdf7367809https://www.arca.fiocruz.br/bitstream/icict/23647/2/Chronic%20Low-Grade%20Inflammation%20in%20Childhood%20Obesity.pdf7fe44c78117bdbeba3fb468364e5ffbbMD52TEXTChronic Low-Grade Inflammation in Childhood Obesity.pdf.txtChronic Low-Grade Inflammation in Childhood Obesity.pdf.txtExtracted texttext/plain258https://www.arca.fiocruz.br/bitstream/icict/23647/3/Chronic%20Low-Grade%20Inflammation%20in%20Childhood%20Obesity.pdf.txtd0fc7f15c87adac427c803bd54f93e0fMD53icict/236472019-06-19 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dc.title.pt_BR.fl_str_mv |
Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets |
title |
Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets |
spellingShingle |
Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets Mattos, Rafael Teixeira de obesidade infantil resposta imune Monocytes Childhood obesity Inflammation Cytokines Obesity Inflammatory diseases Adiponectin Immune response |
title_short |
Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets |
title_full |
Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets |
title_fullStr |
Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets |
title_full_unstemmed |
Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets |
title_sort |
Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets |
author |
Mattos, Rafael Teixeira de |
author_facet |
Mattos, Rafael Teixeira de Medeiros, Nayara Ingrid de Menezes, Carlos A. Fares, Rafaelle Christine Gomes Franco, Eliza P. Dutra, Walderez Ornelas Santos, Fabrıcio Rios Oliveira, Rodrigo Correa de Gomes, Juliana Assis Silva |
author_role |
author |
author2 |
Medeiros, Nayara Ingrid de Menezes, Carlos A. Fares, Rafaelle Christine Gomes Franco, Eliza P. Dutra, Walderez Ornelas Santos, Fabrıcio Rios Oliveira, Rodrigo Correa de Gomes, Juliana Assis Silva |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mattos, Rafael Teixeira de Medeiros, Nayara Ingrid de Menezes, Carlos A. Fares, Rafaelle Christine Gomes Franco, Eliza P. Dutra, Walderez Ornelas Santos, Fabrıcio Rios Oliveira, Rodrigo Correa de Gomes, Juliana Assis Silva |
dc.subject.other.pt_BR.fl_str_mv |
obesidade infantil resposta imune |
topic |
obesidade infantil resposta imune Monocytes Childhood obesity Inflammation Cytokines Obesity Inflammatory diseases Adiponectin Immune response |
dc.subject.en.pt_BR.fl_str_mv |
Monocytes Childhood obesity Inflammation Cytokines Obesity Inflammatory diseases Adiponectin Immune response |
description |
FAPEMIG/CNPq |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-12-13T16:49:29Z |
dc.date.available.fl_str_mv |
2017-12-13T16:49:29Z |
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info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MATTOS, Rafael Teixeira de et al. Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets. Plos One, v. 11, n. 12, art. e0168610, 2016 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/23647 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0168610 |
identifier_str_mv |
MATTOS, Rafael Teixeira de et al. Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets. Plos One, v. 11, n. 12, art. e0168610, 2016 1932-6203 10.1371/journal.pone.0168610 |
url |
https://www.arca.fiocruz.br/handle/icict/23647 |
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eng |
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eng |
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Public Library of Science |
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Public Library of Science |
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