Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines

Detalhes bibliográficos
Autor(a) principal: Ratcliffe, Norman
Data de Publicação: 2014
Outros Autores: Azambuja, Patrícia, Mello, Cícero Brasileiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10201
Resumo: Universidade Federal Fluminense. Departamento de Biologia Geral. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil / Swansea University. College of Science. Department of Biosciences. Swansea, UK.
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spelling Ratcliffe, NormanAzambuja, PatríciaMello, Cícero Brasileiro2015-05-04T17:07:29Z2015-05-04T17:07:29Z2014RATCLIFFE, Norman; AZAMBUJA, Patricia; MELLO, Cícero Brasileiro. Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines. Evidence-Based Complementary and Alternative Medicine, v.2014, Article ID 904958, 21p, 2014.1741-427Xhttps://www.arca.fiocruz.br/handle/icict/1020110.1155/2014/904958engHindawi Publishing CorporationInsetosNatural ProductsInsectFolk MedicineRecent Advances in Developing Insect Natural Products as Potential Modern Day Medicinesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Departamento de Biologia Geral. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil / Swansea University. College of Science. Department of Biosciences. Swansea, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Biologia Geral. Laboratório de Biologia de Insetos. Niterói, RJ, Brasilin their lives. This overview briefly describes significant recent advances in developing insect natural products as potential new medicinal drugs. This is an exciting and rapidly expanding new field since insects are hugely variable and have utilised an enormous range of natural products to survive environmental perturbations for 100s of millions of years. There is thus a treasure chest of untapped resources waiting to be discovered. Insects products, such as silk and honey, have already been utilised for thousands of years, and extracts of insects have been produced for use in Folk Medicine around the world, but only with the development of modern molecular and biochemical techniques has it become feasible to manipulate and bioengineer insect natural products into modern medicines. Utilising knowledge gleaned from Insect Folk Medicines, this review describes modern research into bioengineering honey and venom from bees, silk, cantharidin, antimicrobial peptides, and maggot secretions and anticoagulants from blood-sucking insects into medicines. Problems and solutions encountered in these endeavours are described and indicate that the future is bright for new insect derived pharmaceuticals treatments and medicines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10201/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALpatricia_azambujaetal_IOC_2014.pdfapplication/pdf3274697https://www.arca.fiocruz.br/bitstream/icict/10201/2/patricia_azambujaetal_IOC_2014.pdf70deb7fb9c36c848e6f56a00cac6c5feMD52TEXTpatricia_azambujaetal_IOC_2014.pdf.txtpatricia_azambujaetal_IOC_2014.pdf.txtExtracted texttext/plain118585https://www.arca.fiocruz.br/bitstream/icict/10201/3/patricia_azambujaetal_IOC_2014.pdf.txt43c9d4ee12c777d075fd25ed18f4fdf0MD53icict/102012022-06-24 13:10:42.18oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
title Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
spellingShingle Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
Ratcliffe, Norman
Insetos
Natural Products
Insect
Folk Medicine
title_short Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
title_full Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
title_fullStr Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
title_full_unstemmed Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
title_sort Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines
author Ratcliffe, Norman
author_facet Ratcliffe, Norman
Azambuja, Patrícia
Mello, Cícero Brasileiro
author_role author
author2 Azambuja, Patrícia
Mello, Cícero Brasileiro
author2_role author
author
dc.contributor.author.fl_str_mv Ratcliffe, Norman
Azambuja, Patrícia
Mello, Cícero Brasileiro
dc.subject.other.pt_BR.fl_str_mv Insetos
topic Insetos
Natural Products
Insect
Folk Medicine
dc.subject.en.pt_BR.fl_str_mv Natural Products
Insect
Folk Medicine
description Universidade Federal Fluminense. Departamento de Biologia Geral. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil / Swansea University. College of Science. Department of Biosciences. Swansea, UK.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-04T17:07:29Z
dc.date.available.fl_str_mv 2015-05-04T17:07:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RATCLIFFE, Norman; AZAMBUJA, Patricia; MELLO, Cícero Brasileiro. Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines. Evidence-Based Complementary and Alternative Medicine, v.2014, Article ID 904958, 21p, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10201
dc.identifier.issn.pt_BR.fl_str_mv 1741-427X
dc.identifier.doi.pt_BR.fl_str_mv 10.1155/2014/904958
identifier_str_mv RATCLIFFE, Norman; AZAMBUJA, Patricia; MELLO, Cícero Brasileiro. Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines. Evidence-Based Complementary and Alternative Medicine, v.2014, Article ID 904958, 21p, 2014.
1741-427X
10.1155/2014/904958
url https://www.arca.fiocruz.br/handle/icict/10201
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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