Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.

Detalhes bibliográficos
Autor(a) principal: Lins, Liliane
Data de Publicação: 2012
Outros Autores: Carvalho, Victor José Uchoa de, Rego, Filipe Ferreira de Almeida, Azevedo, Rochele, Kashima, Simone G, Gallazzi, Viviana Nilla Olavarria, Xavier, Marcia Tosta, Castro Filho, Bernardo Galvão, Alcantara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8076
Resumo: Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Salvador, BA, Brasil
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spelling Lins, LilianeCarvalho, Victor José Uchoa deRego, Filipe Ferreira de AlmeidaAzevedo, RocheleKashima, Simone GGallazzi, Viviana Nilla OlavarriaXavier, Marcia TostaCastro Filho, Bernardo GalvãoAlcantara, Luiz Carlos Júnior2014-07-24T17:49:45Z2014-07-24T17:49:45Z2012LINS, L. et al. Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva. Journal of Medical Virology, v. 84, n. 9, p. 1428-1436, 2012.1096-9071https://www.arca.fiocruz.br/handle/icict/807610.1002/jmv.23327engWiley Online LibraryOral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBahiana School of Medicine and Public Health. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Salvador, BA, BrasilBahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilBahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilNational Institute of Science and Technology in Stem Cells and Cell Theraphy University of São Paulo. USP School of Medicine. Ribeirao Preto, SP, BrasilNational Institute of Science and Technology in Stem Cells and Cell Theraphy University of São Paulo. USP School of Medicine. Ribeirao Preto, SP, BrasilBahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilBahiana School of Medicine and Public Health. Salvador, BA, BrasilBahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilBahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilHuman T-lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and has also been implicated in several disorders, including periodontal disease. The proviral load is an important biological marker for understanding HTLV-1 pathogenesis and elucidating whether or not the virus is related to the clinical manifestation of the disease. This study describes the oral health profile of HTLV-1 carriers and HAM/TSP patients in order to investigate the association between the proviral load in saliva and the severity of the periodontal disease and to examine virus intra-host variations from peripheral blood mononuclear cells and saliva cells. It is a cross-sectional analytical study of 90 individuals carried out from November 2006 to May 2008. Of the patients, 60 were HTLV-1 positive and 30 were negative. Individuals from the HTLV-1 positive and negative groups had similar mean age and social-economic status. Data were analyzed using two available statistical software packages, STATA 8.0 and SPSS 11.0 to conduct frequency analysis. Differences of P < 0.05 were considered statistically significant. HTLV-1 patients had poorer oral health status when compared to seronegative individuals. A weak positive correlation between blood and saliva proviral loads was observed. The mean values of proviral load in blood and saliva in patients with HAM/TSP was greater than those in HTLV-1 carriers. The HTLV-1 molecular analysis from PBMC and saliva specimens suggests that HTLV-1 in saliva is due to lymphocyte infiltration from peripheral blood. A direct relationship between the proviral load in saliva and oral manifestations was observed.Oral healthSalivaHTLV-1Portador Sadio/virologiaVírus 1 Linfotrópico T Humano/genéticaParaparesia Espástica Tropical/virologiaProvirus/genéticaSaliva/virologiaCarga ViralAdolescenteAdultoEstudos TransversaisDNA Viral/genéticaDieta CariogênicaFemininoHumanosLeucócitos Mononucleares/virologiaMasculinoMeia-IdadeDoenças Periodontais/virologiaSalivaçãoAnálise de Sequência de DNAAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLins Liliane Oral health profile....pdfLins Liliane Oral health profile....pdfapplication/pdf123808https://www.arca.fiocruz.br/bitstream/icict/8076/1/Lins%20Liliane%20Oral%20health%20profile....pdf5d13c0001a41d53221a8388c058dea62MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8076/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTLins Liliane Oral health profile....pdf.txtLins Liliane Oral health profile....pdf.txtExtracted texttext/plain41126https://www.arca.fiocruz.br/bitstream/icict/8076/3/Lins%20Liliane%20Oral%20health%20profile....pdf.txt0a2b00013fddfc7661e21a46022489dfMD53icict/80762023-03-15 14:33:17.833oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.
title Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.
spellingShingle Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.
Lins, Liliane
Oral health
Saliva
HTLV-1
Portador Sadio/virologia
Vírus 1 Linfotrópico T Humano/genética
Paraparesia Espástica Tropical/virologia
Provirus/genética
Saliva/virologia
Carga Viral
Adolescente
Adulto
Estudos Transversais
DNA Viral/genética
Dieta Cariogênica
Feminino
Humanos
Leucócitos Mononucleares/virologia
Masculino
Meia-Idade
Doenças Periodontais/virologia
Salivação
Análise de Sequência de DNA
Adulto Jovem
title_short Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.
title_full Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.
title_fullStr Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.
title_full_unstemmed Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.
title_sort Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva.
author Lins, Liliane
author_facet Lins, Liliane
Carvalho, Victor José Uchoa de
Rego, Filipe Ferreira de Almeida
Azevedo, Rochele
Kashima, Simone G
Gallazzi, Viviana Nilla Olavarria
Xavier, Marcia Tosta
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
author_role author
author2 Carvalho, Victor José Uchoa de
Rego, Filipe Ferreira de Almeida
Azevedo, Rochele
Kashima, Simone G
Gallazzi, Viviana Nilla Olavarria
Xavier, Marcia Tosta
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lins, Liliane
Carvalho, Victor José Uchoa de
Rego, Filipe Ferreira de Almeida
Azevedo, Rochele
Kashima, Simone G
Gallazzi, Viviana Nilla Olavarria
Xavier, Marcia Tosta
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
dc.subject.en.pt_BR.fl_str_mv Oral health
Saliva
HTLV-1
topic Oral health
Saliva
HTLV-1
Portador Sadio/virologia
Vírus 1 Linfotrópico T Humano/genética
Paraparesia Espástica Tropical/virologia
Provirus/genética
Saliva/virologia
Carga Viral
Adolescente
Adulto
Estudos Transversais
DNA Viral/genética
Dieta Cariogênica
Feminino
Humanos
Leucócitos Mononucleares/virologia
Masculino
Meia-Idade
Doenças Periodontais/virologia
Salivação
Análise de Sequência de DNA
Adulto Jovem
dc.subject.decs.pt_BR.fl_str_mv Portador Sadio/virologia
Vírus 1 Linfotrópico T Humano/genética
Paraparesia Espástica Tropical/virologia
Provirus/genética
Saliva/virologia
Carga Viral
Adolescente
Adulto
Estudos Transversais
DNA Viral/genética
Dieta Cariogênica
Feminino
Humanos
Leucócitos Mononucleares/virologia
Masculino
Meia-Idade
Doenças Periodontais/virologia
Salivação
Análise de Sequência de DNA
Adulto Jovem
description Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Salvador, BA, Brasil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-24T17:49:45Z
dc.date.available.fl_str_mv 2014-07-24T17:49:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LINS, L. et al. Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva. Journal of Medical Virology, v. 84, n. 9, p. 1428-1436, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8076
dc.identifier.issn.none.fl_str_mv 1096-9071
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.23327
identifier_str_mv LINS, L. et al. Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva. Journal of Medical Virology, v. 84, n. 9, p. 1428-1436, 2012.
1096-9071
10.1002/jmv.23327
url https://www.arca.fiocruz.br/handle/icict/8076
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Online Library
publisher.none.fl_str_mv Wiley Online Library
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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