Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8079 |
Resumo: | Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. IBOPC. Salvador, BA, Brasil. |
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Vargens, Cristina Castro LimaGrassi, Maria Fernanda RiosBoa-Sorte, Ney Cristian AmaralPinheiro, Regina Helena RathsamGallazzi, Viviana Nilla OlavarriaKruschewsky, Ramon de AlmeidaCastro Filho, Bernardo Galvão2014-07-25T17:19:42Z2014-07-25T17:19:42Z2011VARGENS, C. C. L. et al. Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load. Journal of Clinical Virology, v. 52, n. 3, p. 177-180, 2011.1873-5967https://www.arca.fiocruz.br/handle/icict/807910.1016/j.jcv.2011.07.016engElsevierKeratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral loadinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Brasileiro de Oftalmologia e Prevenção da Cegueira. IBOPC. Salvador, BA, Brasil.Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil.Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil.Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. IBOPC. Salvador, BA, Brasil / Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil.Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde .Pública. Salvador, BA, BrasilInstituto Brasileiro de Oftalmologia e Prevenção da Cegueira. IBOPC. Salvador, BA, Brasil.Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.BACKGROUND: A high HTLV-1 proviral load is found in HTLV-1-associated diseases, mainly HAM/TSP. However, the association between proviral load and keratoconjunctivitis sicca (KCS) has not been well established. AIM: To verify the association between KCS and HTLV-1 proviral load. STUDY DESIGN: 104 HTLV-1 infected patients (51 asymptomatic and 52 with HAM/TSP) from the HTLV reference center in Salvador, Brazil were followed from June 2008 to May 2010. Evaluation of tear secretion was performed by BUT (break-up time), Rose Bengal and Schirmer I tests. The diagnosis of KCS was based upon the presence of symptoms and when at least two of three tests were positive. HTLV-1 proviral load was determined using real-time PCR. RESULTS: The prevalence of KCS was 44.2%. KCS was more frequent among HAM/TSP patients (p = 0.022). Patients with KCS had higher proviral load (mean 134,672 ± 150,393copies/10(6) PBMC) than patients without the disease (mean 66,880 ± 109,525copies/10(6) PBMC) (p = 0.001). HTLV-1 proviral load>100,000copies/10(6) PBMC increased significantly the risk of developing KCS (OR = 4.05 and 95% CI = 1.40-11.76). After age>45 years and HAM/TSP status were excluded in stepway reward analysis, the variables PVL>100,000 (OR = 4.77 and 95% CI = 1.83-12.44) still remained statistically significant. CONCLUSION: HTLV-1 proviral loads are higher in patients with KCS and may represent a relevant biological marker of disease.HTLV-1Ocular lesionsKeratoconjuntivitis siccaProviral loadInfecções por HTLV-I/virologiaVírus 1 Linfotrópico T Humano/fisiologiaCeratoconjuntivite Seca/virologiaProvirus/fisiologiaCarga ViralAdolescenteAdultoIdosoIdoso de 80 Anos ou maisMarcadores BiológicosBrasilCriançaDNA Viral/análiseFemininoInfecções por HTLV-I/diagnósticoVírus 1 Linfotrópico T Humano/genéticaHumanosCeratoconjuntivite Seca/diagnósticoMasculinoMeia-IdadeParaparesia Espástica Tropical/diagnósticoParaparesia Espástica Tropical/virologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALVargens CLV Keratoconjunctivitis sicca....pdfVargens CLV Keratoconjunctivitis sicca....pdfapplication/pdf198431https://www.arca.fiocruz.br/bitstream/icict/8079/1/Vargens%20CLV%20Keratoconjunctivitis%20sicca....pdffccb0e7cfe2c79a57fee556ace0172efMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8079/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTVargens CLV Keratoconjunctivitis sicca....pdf.txtVargens CLV Keratoconjunctivitis sicca....pdf.txtExtracted texttext/plain26520https://www.arca.fiocruz.br/bitstream/icict/8079/3/Vargens%20CLV%20Keratoconjunctivitis%20sicca....pdf.txt7f58463916f72eb28e02dc7a793bf086MD53icict/80792023-03-15 14:33:17.589oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load |
| title |
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load |
| spellingShingle |
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load Vargens, Cristina Castro Lima HTLV-1 Ocular lesions Keratoconjuntivitis sicca Proviral load Infecções por HTLV-I/virologia Vírus 1 Linfotrópico T Humano/fisiologia Ceratoconjuntivite Seca/virologia Provirus/fisiologia Carga Viral Adolescente Adulto Idoso Idoso de 80 Anos ou mais Marcadores Biológicos Brasil Criança DNA Viral/análise Feminino Infecções por HTLV-I/diagnóstico Vírus 1 Linfotrópico T Humano/genética Humanos Ceratoconjuntivite Seca/diagnóstico Masculino Meia-Idade Paraparesia Espástica Tropical/diagnóstico Paraparesia Espástica Tropical/virologia |
| title_short |
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load |
| title_full |
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load |
| title_fullStr |
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load |
| title_full_unstemmed |
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load |
| title_sort |
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load |
| author |
Vargens, Cristina Castro Lima |
| author_facet |
Vargens, Cristina Castro Lima Grassi, Maria Fernanda Rios Boa-Sorte, Ney Cristian Amaral Pinheiro, Regina Helena Rathsam Gallazzi, Viviana Nilla Olavarria Kruschewsky, Ramon de Almeida Castro Filho, Bernardo Galvão |
| author_role |
author |
| author2 |
Grassi, Maria Fernanda Rios Boa-Sorte, Ney Cristian Amaral Pinheiro, Regina Helena Rathsam Gallazzi, Viviana Nilla Olavarria Kruschewsky, Ramon de Almeida Castro Filho, Bernardo Galvão |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Vargens, Cristina Castro Lima Grassi, Maria Fernanda Rios Boa-Sorte, Ney Cristian Amaral Pinheiro, Regina Helena Rathsam Gallazzi, Viviana Nilla Olavarria Kruschewsky, Ramon de Almeida Castro Filho, Bernardo Galvão |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1 Ocular lesions Keratoconjuntivitis sicca Proviral load |
| topic |
HTLV-1 Ocular lesions Keratoconjuntivitis sicca Proviral load Infecções por HTLV-I/virologia Vírus 1 Linfotrópico T Humano/fisiologia Ceratoconjuntivite Seca/virologia Provirus/fisiologia Carga Viral Adolescente Adulto Idoso Idoso de 80 Anos ou mais Marcadores Biológicos Brasil Criança DNA Viral/análise Feminino Infecções por HTLV-I/diagnóstico Vírus 1 Linfotrópico T Humano/genética Humanos Ceratoconjuntivite Seca/diagnóstico Masculino Meia-Idade Paraparesia Espástica Tropical/diagnóstico Paraparesia Espástica Tropical/virologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Infecções por HTLV-I/virologia Vírus 1 Linfotrópico T Humano/fisiologia Ceratoconjuntivite Seca/virologia Provirus/fisiologia Carga Viral Adolescente Adulto Idoso Idoso de 80 Anos ou mais Marcadores Biológicos Brasil Criança DNA Viral/análise Feminino Infecções por HTLV-I/diagnóstico Vírus 1 Linfotrópico T Humano/genética Humanos Ceratoconjuntivite Seca/diagnóstico Masculino Meia-Idade Paraparesia Espástica Tropical/diagnóstico Paraparesia Espástica Tropical/virologia |
| description |
Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. IBOPC. Salvador, BA, Brasil. |
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2011 |
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2011 |
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2014-07-25T17:19:42Z |
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2014-07-25T17:19:42Z |
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info:eu-repo/semantics/article |
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VARGENS, C. C. L. et al. Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load. Journal of Clinical Virology, v. 52, n. 3, p. 177-180, 2011. |
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https://www.arca.fiocruz.br/handle/icict/8079 |
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1873-5967 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.jcv.2011.07.016 |
| identifier_str_mv |
VARGENS, C. C. L. et al. Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load. Journal of Clinical Virology, v. 52, n. 3, p. 177-180, 2011. 1873-5967 10.1016/j.jcv.2011.07.016 |
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Elsevier |
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Elsevier |
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