Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.

Detalhes bibliográficos
Autor(a) principal: Sudharshan, Sridharan
Data de Publicação: 2020
Outros Autores: Nair, Nivedita, Curi, Andre, Banker, Alay, Kempen, John H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43894
Resumo: Medical Research Foundation. Department of Uveitis. Chennai, Tamil Nadu, India.
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spelling Sudharshan, SridharanNair, NiveditaCuri, AndreBanker, AlayKempen, John H.2020-10-08T21:50:54Z2020-10-08T21:50:54Z2020SUDHARSHAN, Sridharan et al. Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update. Indian Journal of Ophthalmology, v. 68, n. 9, p. 1787-1798, 2020.0301-4738https://www.arca.fiocruz.br/handle/icict/4389410.4103/ijo.IJO_1248_20engWolters KlumerHuman immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMedical Research Foundation. Department of Uveitis. Chennai, Tamil Nadu, India.Medical Research Foundation. Department of Uveitis. Chennai, Tamil Nadu, India.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Banker's Retina Clinic and Laser Centre. Ahmedabad, Gujarat, India.Massachusetts Eye and Ear and Harvard Medical School. Department of Ophthalmology. Boston, Massachusetts, USA / Schepens Eye Research Institute. Boston, Massachusetts, USA / MyungSung Christian Medical Center (MCM) General Hospital and MyungSung Medical College. MCM Eye Unit. Addis Ababa, Ethiopia.Intraocular inflammation in patients with human immunodeficiency virus (HIV) infection is commonly due to infectious uveitis. Ocular lesions due to opportunistic infections (OI) are the most common and have been described extensively in the pre highly active antiretroviral therapy (HAART) era. Many eye lesions were classified as acquired immunodeficiency syndrome (AIDS) defining illnesses. HAART-associated improvement in immunity of the individual has changed the pattern of incidence of these hitherto reported known lesions leading to a marked reduction in the occurrence of ocular OI. Newer ocular lesions and newer ocular manifestations of known agents have been noted. Immune recovery uveitis (IRU), the new menace, which occurs as part of immune recovery inflammatory syndrome (IRIS) in the eye, can present with significant ocular inflammation and can pose a diagnostic and therapeutic challenge. Balancing the treatment of inflammation with the risk of reactivation of OI is a task by itself. Ocular involvement in the HAART era can be due to the adverse effects of some systemic drugs used in the management of HIV/AIDS. Drug-associated retinal toxicity and other ocular side effects are being increasingly reported. In this review, we discuss the ocular manifestations in HIV patients and its varied presentations following the introduction of HAART, drug-associated lesions, and the current treatment guidelines.AIDSCMV retinitisHAARTHIVIRUDrug-induced uveitisHerpes zosterIntraocular inflammationOcular TBOcular opportunistic infectionsOcular syphilisOcular toxoplasmosisRetinopathyUveitisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/43894/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALsridharan_sudharshan_et_all.pdfapplication/pdf1437376https://www.arca.fiocruz.br/bitstream/icict/43894/2/sridharan_sudharshan_et_all.pdf426bc28da2d96b23384a6d5b5e96aa5fMD52icict/438942020-10-09 10:11:46.171oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-10-09T13:11:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
title Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
spellingShingle Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
Sudharshan, Sridharan
AIDS
CMV retinitis
HAART
HIV
IRU
Drug-induced uveitis
Herpes zoster
Intraocular inflammation
Ocular TB
Ocular opportunistic infections
Ocular syphilis
Ocular toxoplasmosis
Retinopathy
Uveitis
title_short Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
title_full Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
title_fullStr Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
title_full_unstemmed Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
title_sort Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update.
author Sudharshan, Sridharan
author_facet Sudharshan, Sridharan
Nair, Nivedita
Curi, Andre
Banker, Alay
Kempen, John H.
author_role author
author2 Nair, Nivedita
Curi, Andre
Banker, Alay
Kempen, John H.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sudharshan, Sridharan
Nair, Nivedita
Curi, Andre
Banker, Alay
Kempen, John H.
dc.subject.en.pt_BR.fl_str_mv AIDS
CMV retinitis
HAART
HIV
IRU
Drug-induced uveitis
Herpes zoster
Intraocular inflammation
Ocular TB
Ocular opportunistic infections
Ocular syphilis
Ocular toxoplasmosis
Retinopathy
Uveitis
topic AIDS
CMV retinitis
HAART
HIV
IRU
Drug-induced uveitis
Herpes zoster
Intraocular inflammation
Ocular TB
Ocular opportunistic infections
Ocular syphilis
Ocular toxoplasmosis
Retinopathy
Uveitis
description Medical Research Foundation. Department of Uveitis. Chennai, Tamil Nadu, India.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-08T21:50:54Z
dc.date.available.fl_str_mv 2020-10-08T21:50:54Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SUDHARSHAN, Sridharan et al. Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update. Indian Journal of Ophthalmology, v. 68, n. 9, p. 1787-1798, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43894
dc.identifier.issn.pt_BR.fl_str_mv 0301-4738
dc.identifier.doi.none.fl_str_mv 10.4103/ijo.IJO_1248_20
identifier_str_mv SUDHARSHAN, Sridharan et al. Human immunodeficiency virus and intraocular inflammation in the era of highly active anti retroviral therapy - An update. Indian Journal of Ophthalmology, v. 68, n. 9, p. 1787-1798, 2020.
0301-4738
10.4103/ijo.IJO_1248_20
url https://www.arca.fiocruz.br/handle/icict/43894
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wolters Klumer
publisher.none.fl_str_mv Wolters Klumer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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