Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance

Detalhes bibliográficos
Autor(a) principal: Bressan, Clarisse da Silveira
Data de Publicação: 2023
Outros Autores: Teixeira, Maria de Lourdes Benamor, Gouvêa, Maria Isabel Fragoso da Silveira, Pina-Costa, Anielle de, Santos, Heloísa Ferreira Pinto, Calvet, Guilherme Amaral, Lupi, Otilia, Siqueira, Andre Machado, Valls-de-Souza, Rogério, Valim, Clarissa, Brasil, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pntd.0011232
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58828
Resumo: Dr PB is supported by Carlos Chagas Foundation for the Advancement of Science of the State of Rio de Janeiro (FAPERJ), https://www.faperj.br/, grant numbers [E-26/200.935/2022] and [E-26/211.565/2019]; by DECIT, www.saude.gov. br/sctie/decit, grant number 25000.072811/2016-19; and by CNPQ, https://www.gov.br/cnpq/pt-br, grant number 311562/2021-3. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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spelling Bressan, Clarisse da SilveiraTeixeira, Maria de Lourdes BenamorGouvêa, Maria Isabel Fragoso da SilveiraPina-Costa, Anielle deSantos, Heloísa Ferreira PintoCalvet, Guilherme AmaralLupi, OtiliaSiqueira, Andre MachadoValls-de-Souza, RogérioValim, ClarissaBrasil, Patrícia2023-05-31T01:21:51Z2023-05-31T01:21:51Z2023BRESSAN, Clarisse da Silveira et al. Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance. PLoS Neglected Tropical Diseases, v. 17, n. 4, p. 1-13, Apr. 2023.1935-2727https://www.arca.fiocruz.br/handle/icict/5882810.1371/journal.pntd.00112321935-2735Dr PB is supported by Carlos Chagas Foundation for the Advancement of Science of the State of Rio de Janeiro (FAPERJ), https://www.faperj.br/, grant numbers [E-26/200.935/2022] and [E-26/211.565/2019]; by DECIT, www.saude.gov. br/sctie/decit, grant number 25000.072811/2016-19; and by CNPQ, https://www.gov.br/cnpq/pt-br, grant number 311562/2021-3. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Acute Febrile Illnesses Service. Rio de Janeiro, Rio de Janeiro, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Laboratory of Epidemiology Research and Social Determinants of Health. Rio de Janeiro, Rio de Janeiro, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Laboratory of Epidemiology Research and Social Determinants of Health. Rio de Janeiro, Rio de Janeiro, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Acute Febrile Illnesses Service. Rio de Janeiro, Rio de Janeiro, Brazil / Universidade Federal Fluminense. Niterói, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Acute Febrile Illnesses Service. Rio de Janeiro, Rio de Janeiro, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Acute Febrile Illnesses Service. Rio de Janeiro, Rio de Janeiro, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Acute Febrile Illnesses Service. Rio de Janeiro, Rio de Janeiro, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Acute Febrile Illnesses Service. Rio de Janeiro, Rio de Janeiro, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Acute Febrile Illnesses Service. Rio de Janeiro, Rio de Janeiro, Brazil.Boston University School of Public Health. Department of Global Health. Boston, Massachusetts, USA.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. Acute Febrile Illnesses Service. Rio de Janeiro, Rio de Janeiro, Brazil.Introduction: Acute febrile illnesses (AFI) are a frequent chief complaint in outpatients. Because the capacity to investigate the causative pathogen of AFIs is limited in low- and middle-income countries, patient management may be suboptimal. Understanding the distribution of causes of AFI can improve patient outcomes. This study aims to describe the most common etiologies diagnosed over a 16-years period in a national reference center for tropical diseases in a large urban center in Rio de Janeiro, Brazil. Methods: From August 2004-December 2019, 3591 patients > 12 years old, with AFI and/or rash were eligible. Complementary exams for etiological investigation were requested using syndromic classification as a decision guide. Results. Among the 3591 patients included, endemic arboviruses such as chikungunya (21%), dengue (15%) and zika (6%) were the most common laboratory-confirmed diagnosis, together with travel-related malaria (11%). Clinical presumptive diagnosis lacked sensitivity for emerging diseases such as zika (31%). Rickettsia disease and leptospirosis were rarely investigated and an infrequent finding when based purely on clinical features. Respiratory symptoms increased the odds for the diagnostic remaining inconclusive. Conclusions: Numerous patients did not have a conclusive etiologic diagnosis. Since syndromic classification used for standardization of etiological investigation and presumptive clinical diagnosis had moderate accuracy, it is necessary to incorporate new diagnostic technologies to improve diagnostic accuracy and surveillance capacity.engPublic Library of ScienceChallenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAcute febrile illnesses (AFI)Etiologies diagnosedTropical diseasesPatientsEtiologic diagnosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Clarisse_Bressan_etal_INI_2023.pdfve_Clarisse_Bressan_etal_INI_2023.pdfapplication/pdf1442196https://www.arca.fiocruz.br/bitstream/icict/58828/2/ve_Clarisse_Bressan_etal_INI_2023.pdf6661b61d05a98d5785759cc030c8a7dfMD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
title Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
spellingShingle Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
Bressan, Clarisse da Silveira
Acute febrile illnesses (AFI)
Etiologies diagnosed
Tropical diseases
Patients
Etiologic diagnosis
title_short Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
title_full Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
title_fullStr Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
title_full_unstemmed Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
title_sort Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance
author Bressan, Clarisse da Silveira
author_facet Bressan, Clarisse da Silveira
Teixeira, Maria de Lourdes Benamor
Gouvêa, Maria Isabel Fragoso da Silveira
Pina-Costa, Anielle de
Santos, Heloísa Ferreira Pinto
Calvet, Guilherme Amaral
Lupi, Otilia
Siqueira, Andre Machado
Valls-de-Souza, Rogério
Valim, Clarissa
Brasil, Patrícia
author_role author
author2 Teixeira, Maria de Lourdes Benamor
Gouvêa, Maria Isabel Fragoso da Silveira
Pina-Costa, Anielle de
Santos, Heloísa Ferreira Pinto
Calvet, Guilherme Amaral
Lupi, Otilia
Siqueira, Andre Machado
Valls-de-Souza, Rogério
Valim, Clarissa
Brasil, Patrícia
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bressan, Clarisse da Silveira
Teixeira, Maria de Lourdes Benamor
Gouvêa, Maria Isabel Fragoso da Silveira
Pina-Costa, Anielle de
Santos, Heloísa Ferreira Pinto
Calvet, Guilherme Amaral
Lupi, Otilia
Siqueira, Andre Machado
Valls-de-Souza, Rogério
Valim, Clarissa
Brasil, Patrícia
dc.subject.en.en_US.fl_str_mv Acute febrile illnesses (AFI)
Etiologies diagnosed
Tropical diseases
Patients
Etiologic diagnosis
topic Acute febrile illnesses (AFI)
Etiologies diagnosed
Tropical diseases
Patients
Etiologic diagnosis
description Dr PB is supported by Carlos Chagas Foundation for the Advancement of Science of the State of Rio de Janeiro (FAPERJ), https://www.faperj.br/, grant numbers [E-26/200.935/2022] and [E-26/211.565/2019]; by DECIT, www.saude.gov. br/sctie/decit, grant number 25000.072811/2016-19; and by CNPQ, https://www.gov.br/cnpq/pt-br, grant number 311562/2021-3. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-31T01:21:51Z
dc.date.available.fl_str_mv 2023-05-31T01:21:51Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRESSAN, Clarisse da Silveira et al. Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance. PLoS Neglected Tropical Diseases, v. 17, n. 4, p. 1-13, Apr. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58828
dc.identifier.issn.en_US.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0011232
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv BRESSAN, Clarisse da Silveira et al. Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance. PLoS Neglected Tropical Diseases, v. 17, n. 4, p. 1-13, Apr. 2023.
1935-2727
10.1371/journal.pntd.0011232
1935-2735
url https://www.arca.fiocruz.br/handle/icict/58828
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58828/2/ve_Clarisse_Bressan_etal_INI_2023.pdf
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