Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?

Detalhes bibliográficos
Autor(a) principal: Lannes-Vieira, Joseli
Data de Publicação: 2003
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33640
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunudade e Imuno-Regulação. Rio de Janeiro, RJ, Brasil.
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spelling Lannes-Vieira, Joseli2019-06-24T17:05:32Z2019-06-24T17:05:32Z2003LANNES-VIEIRA, Joseli. Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 3, p.299-304, Apr. 2003.0074-0276https://www.arca.fiocruz.br/handle/icict/3364010.1590/S0074-027620030003000021678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Trypanosoma cruziQumiocinasTerapiaInflamaçãoMoléculas de adesãoTrypanosoma cruziTherapyAdhesion moleculesInflammationChemokinesTrypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunudade e Imuno-Regulação. Rio de Janeiro, RJ, Brasil.In Chagas disease, during the acute phase, the establishment of inflammatory processes is crucial for Trypanosoma cruzi control in target tissues and for the establishment of host/parasite equilibrium. However, in about 30% of the patients, inflammation becomes progressive, resulting in chronic disease, mainly characterized by myocarditis. Although several hypothesis have been raised to explain the pathogenesis of chagasic myocardiopathy, including the persistence of the parasite and/or participation of autoimmune processes, the molecular mechanisms underlying the establishment of the inflammatory process leading to parasitism control but also contributing to the maintenance of T. cruzi-elicited chronic myocarditis remain unsolved. Trying to shed light on these questions, we have for several years been working with murine models for Chagas disease that reproduce the acute self-resolving meningoencephalitis, the encephalitis resulting of reactivation described in immunodeficient individuals, and several aspects of the acute and chronic myocarditis. In the present review, our results are summarized and discussed under the light of the current literature. Furthermore, rational therapeutic intervention strategies based on integrin-mediated adhesion and chemokine receptor-driven recruitment of leukocytes are proposed to control T. cruzi-elicited unbalanced inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33640/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseliLannesVieira_IOC_2003.pdfJoseliLannesVieira_IOC_2003.pdfapplication/pdf680208https://www.arca.fiocruz.br/bitstream/icict/33640/2/JoseliLannesVieira_IOC_2003.pdf1f3f9a66a8b4b2946e2a17a63326af0fMD52TEXTJoseliLannesVieira_IOC_2003.pdf.txtJoseliLannesVieira_IOC_2003.pdf.txtExtracted texttext/plain29265https://www.arca.fiocruz.br/bitstream/icict/33640/3/JoseliLannesVieira_IOC_2003.pdf.txt5f50092e899088b2406848d9558ec66bMD53icict/336402019-06-25 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dc.title.pt_BR.fl_str_mv Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
title Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
spellingShingle Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
Lannes-Vieira, Joseli
Trypanosoma cruzi
Qumiocinas
Terapia
Inflamação
Moléculas de adesão
Trypanosoma cruzi
Therapy
Adhesion molecules
Inflammation
Chemokines
title_short Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
title_full Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
title_fullStr Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
title_full_unstemmed Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
title_sort Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
author Lannes-Vieira, Joseli
author_facet Lannes-Vieira, Joseli
author_role author
dc.contributor.author.fl_str_mv Lannes-Vieira, Joseli
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Qumiocinas
Terapia
Inflamação
Moléculas de adesão
topic Trypanosoma cruzi
Qumiocinas
Terapia
Inflamação
Moléculas de adesão
Trypanosoma cruzi
Therapy
Adhesion molecules
Inflammation
Chemokines
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Therapy
Adhesion molecules
Inflammation
Chemokines
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunudade e Imuno-Regulação. Rio de Janeiro, RJ, Brasil.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2019-06-24T17:05:32Z
dc.date.available.fl_str_mv 2019-06-24T17:05:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LANNES-VIEIRA, Joseli. Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 3, p.299-304, Apr. 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33640
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762003000300002
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv LANNES-VIEIRA, Joseli. Trypanosoma cruzi-elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 98, n. 3, p.299-304, Apr. 2003.
0074-0276
10.1590/S0074-02762003000300002
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33640
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/33640/3/JoseliLannesVieira_IOC_2003.pdf.txt
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