Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.

Detalhes bibliográficos
Autor(a) principal: Filgueiras, Priscilla Soares
Data de Publicação: 2023
Outros Autores: Corsini, Camila Amormino, Almeida, Nathalie Bonatti Franco, Pedrosa, Maria Luysa Camargos, Miranda, Daniel Alvim Pena de, Gomes, Sarah Vieira Contin, Assis, Jéssica Vieira de, Silva, Raphael Antônio, Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de, Lourenço, Adelina Junia, Bicalho, Cecilia Maria Florencio, Vilela, Raquel Virginia Rocha, Jeremias, Wander de Jesus, Fernandes, Gabriel da Rocha, Queiroz, Rafaella Fortini Grenfell e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59189
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil.
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spelling Filgueiras, Priscilla SoaresCorsini, Camila AmorminoAlmeida, Nathalie Bonatti FrancoPedrosa, Maria Luysa CamargosMiranda, Daniel Alvim Pena deGomes, Sarah Vieira ContinAssis, Jéssica Vieira deSilva, Raphael AntônioMedeiros, Maria Izabella Vieira de Assis Rocha Carvalho deLourenço, Adelina JuniaBicalho, Cecilia Maria FlorencioVilela, Raquel Virginia RochaJeremias, Wander de JesusFernandes, Gabriel da RochaQueiroz, Rafaella Fortini Grenfell e2023-06-27T14:09:53Z2023-06-27T14:09:53Z2023FILGUEIRAS, Priscilla Soares et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Rev Soc Bras Med Trop, v. 56, p. e01672022-e01672022, 2023. doi:.org/10.1590/0037-8682-0167-2022.1678-9849https://www.arca.fiocruz.br/handle/icict/59189engSociedade Brasileira De Medicina TropicalRapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade da Geórgia. Faculdade de Medicina Veterinária. Departamento de Doenças Infecciosas. Athens, GA, Estados Unidos da América.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães. Hospital da Baleia. Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães. Hospital da Baleia. Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães. Hospital da Baleia. Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães, Hospital da Baleia, Belo Horizonte, MG, Brasil.Fundação Benjamin Guimarães. Hospital da Baleia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Ouro Preto. Departamento de Farmácia. Ouro Preto, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Informática de Biossistemas. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil/Universidade da Geórgia. Faculdade de Medicina Veterinária. Departamento de Doenças Infecciosas. Athens, GA, Estados Unidos da AméricaBackground: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigendetecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control.COVID-19SARS-CoV-2Rapid testAntigen testSelf-testinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59189/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRapid antigen test as a tool for the identification.pdfRapid antigen test as a tool for the identification.pdfapplication/pdf437960https://www.arca.fiocruz.br/bitstream/icict/59189/2/Rapid%20antigen%20test%20as%20a%20tool%20for%20the%20identification.pdfc47027b3f42893f620ef9f885358333bMD52icict/591892023-06-27 11:09:54.327oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-27T14:09:54Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
spellingShingle Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
Filgueiras, Priscilla Soares
COVID-19
SARS-CoV-2
Rapid test
Antigen test
Self-test
title_short Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title_full Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title_fullStr Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title_full_unstemmed Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title_sort Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
author Filgueiras, Priscilla Soares
author_facet Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Almeida, Nathalie Bonatti Franco
Pedrosa, Maria Luysa Camargos
Miranda, Daniel Alvim Pena de
Gomes, Sarah Vieira Contin
Assis, Jéssica Vieira de
Silva, Raphael Antônio
Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de
Lourenço, Adelina Junia
Bicalho, Cecilia Maria Florencio
Vilela, Raquel Virginia Rocha
Jeremias, Wander de Jesus
Fernandes, Gabriel da Rocha
Queiroz, Rafaella Fortini Grenfell e
author_role author
author2 Corsini, Camila Amormino
Almeida, Nathalie Bonatti Franco
Pedrosa, Maria Luysa Camargos
Miranda, Daniel Alvim Pena de
Gomes, Sarah Vieira Contin
Assis, Jéssica Vieira de
Silva, Raphael Antônio
Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de
Lourenço, Adelina Junia
Bicalho, Cecilia Maria Florencio
Vilela, Raquel Virginia Rocha
Jeremias, Wander de Jesus
Fernandes, Gabriel da Rocha
Queiroz, Rafaella Fortini Grenfell e
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Almeida, Nathalie Bonatti Franco
Pedrosa, Maria Luysa Camargos
Miranda, Daniel Alvim Pena de
Gomes, Sarah Vieira Contin
Assis, Jéssica Vieira de
Silva, Raphael Antônio
Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de
Lourenço, Adelina Junia
Bicalho, Cecilia Maria Florencio
Vilela, Raquel Virginia Rocha
Jeremias, Wander de Jesus
Fernandes, Gabriel da Rocha
Queiroz, Rafaella Fortini Grenfell e
dc.subject.en.en_US.fl_str_mv COVID-19
SARS-CoV-2
Rapid test
Antigen test
Self-test
topic COVID-19
SARS-CoV-2
Rapid test
Antigen test
Self-test
description Fundação Oswaldo Cruz. Instituto René Rachou. Diagnóstico e Terapia de Doenças Infecciosas e Câncer. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Patologia. Belo Horizonte, MG, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-27T14:09:53Z
dc.date.available.fl_str_mv 2023-06-27T14:09:53Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv FILGUEIRAS, Priscilla Soares et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Rev Soc Bras Med Trop, v. 56, p. e01672022-e01672022, 2023. doi:.org/10.1590/0037-8682-0167-2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59189
dc.identifier.issn.en_US.fl_str_mv 1678-9849
identifier_str_mv FILGUEIRAS, Priscilla Soares et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Rev Soc Bras Med Trop, v. 56, p. e01672022-e01672022, 2023. doi:.org/10.1590/0037-8682-0167-2022.
1678-9849
url https://www.arca.fiocruz.br/handle/icict/59189
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira De Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira De Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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