Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.

Detalhes bibliográficos
Autor(a) principal: Filgueiras, Priscilla Soares
Data de Publicação: 2023
Outros Autores: Corsini, Camila Amormino, Almeida, Nathalie Bonatti Franco, Pedrosa, Maria Luysa Camargos, Miranda, Daniel Alvim Pena de, Gomes, Sarah Vieira Contin, Assis, Jéssica Vieira de, Silva, Raphael Antônio, Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de, Lourenço, Adelina Junia, Bicalho, Cecilia Maria Florencio, Vilela, Raquel Virgínia Rocha, Jeremias, Wander de Jesus, Fernandes, Gabriel da Rocha, Grenfell, Rafaella Fortini Queiroz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/jspui/handle/123456789/17628
https://doi.org/10.1590/0037-8682-0167-2022
Resumo: Background: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen- detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control.
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spelling Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.Covid-19Rapid testSelf-testBackground: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen- detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control.2023-10-20T19:23:13Z2023-10-20T19:23:13Z2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfFILGUEIRAS, P. S. et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Revista da Sociedade Brasileira de Medicina Tropical, v. 56, artigo e0167, 2023. Disponível em: <https://www.scielo.br/j/rsbmt/a/TyFVt3tgWVdztfdrRXKyykG/>. Acesso em: 01 ago. 2023.1678-9849http://www.repositorio.ufop.br/jspui/handle/123456789/17628https://doi.org/10.1590/0037-8682-0167-2022This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.info:eu-repo/semantics/openAccessFilgueiras, Priscilla SoaresCorsini, Camila AmorminoAlmeida, Nathalie Bonatti FrancoPedrosa, Maria Luysa CamargosMiranda, Daniel Alvim Pena deGomes, Sarah Vieira ContinAssis, Jéssica Vieira deSilva, Raphael AntônioMedeiros, Maria Izabella Vieira de Assis Rocha Carvalho deLourenço, Adelina JuniaBicalho, Cecilia Maria FlorencioVilela, Raquel Virgínia RochaJeremias, Wander de JesusFernandes, Gabriel da RochaGrenfell, Rafaella Fortini Queirozengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2023-10-20T19:23:22Zoai:repositorio.ufop.br:123456789/17628Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332023-10-20T19:23:22Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
spellingShingle Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
Filgueiras, Priscilla Soares
Covid-19
Rapid test
Self-test
title_short Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title_full Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title_fullStr Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title_full_unstemmed Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
title_sort Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
author Filgueiras, Priscilla Soares
author_facet Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Almeida, Nathalie Bonatti Franco
Pedrosa, Maria Luysa Camargos
Miranda, Daniel Alvim Pena de
Gomes, Sarah Vieira Contin
Assis, Jéssica Vieira de
Silva, Raphael Antônio
Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de
Lourenço, Adelina Junia
Bicalho, Cecilia Maria Florencio
Vilela, Raquel Virgínia Rocha
Jeremias, Wander de Jesus
Fernandes, Gabriel da Rocha
Grenfell, Rafaella Fortini Queiroz
author_role author
author2 Corsini, Camila Amormino
Almeida, Nathalie Bonatti Franco
Pedrosa, Maria Luysa Camargos
Miranda, Daniel Alvim Pena de
Gomes, Sarah Vieira Contin
Assis, Jéssica Vieira de
Silva, Raphael Antônio
Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de
Lourenço, Adelina Junia
Bicalho, Cecilia Maria Florencio
Vilela, Raquel Virgínia Rocha
Jeremias, Wander de Jesus
Fernandes, Gabriel da Rocha
Grenfell, Rafaella Fortini Queiroz
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Almeida, Nathalie Bonatti Franco
Pedrosa, Maria Luysa Camargos
Miranda, Daniel Alvim Pena de
Gomes, Sarah Vieira Contin
Assis, Jéssica Vieira de
Silva, Raphael Antônio
Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de
Lourenço, Adelina Junia
Bicalho, Cecilia Maria Florencio
Vilela, Raquel Virgínia Rocha
Jeremias, Wander de Jesus
Fernandes, Gabriel da Rocha
Grenfell, Rafaella Fortini Queiroz
dc.subject.por.fl_str_mv Covid-19
Rapid test
Self-test
topic Covid-19
Rapid test
Self-test
description Background: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen- detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-20T19:23:13Z
2023-10-20T19:23:13Z
2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv FILGUEIRAS, P. S. et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Revista da Sociedade Brasileira de Medicina Tropical, v. 56, artigo e0167, 2023. Disponível em: <https://www.scielo.br/j/rsbmt/a/TyFVt3tgWVdztfdrRXKyykG/>. Acesso em: 01 ago. 2023.
1678-9849
http://www.repositorio.ufop.br/jspui/handle/123456789/17628
https://doi.org/10.1590/0037-8682-0167-2022
identifier_str_mv FILGUEIRAS, P. S. et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Revista da Sociedade Brasileira de Medicina Tropical, v. 56, artigo e0167, 2023. Disponível em: <https://www.scielo.br/j/rsbmt/a/TyFVt3tgWVdztfdrRXKyykG/>. Acesso em: 01 ago. 2023.
1678-9849
url http://www.repositorio.ufop.br/jspui/handle/123456789/17628
https://doi.org/10.1590/0037-8682-0167-2022
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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