Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/jspui/handle/123456789/17628 https://doi.org/10.1590/0037-8682-0167-2022 |
Resumo: | Background: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen- detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control. |
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Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.Covid-19Rapid testSelf-testBackground: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen- detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control.2023-10-20T19:23:13Z2023-10-20T19:23:13Z2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfFILGUEIRAS, P. S. et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Revista da Sociedade Brasileira de Medicina Tropical, v. 56, artigo e0167, 2023. Disponível em: <https://www.scielo.br/j/rsbmt/a/TyFVt3tgWVdztfdrRXKyykG/>. Acesso em: 01 ago. 2023.1678-9849http://www.repositorio.ufop.br/jspui/handle/123456789/17628https://doi.org/10.1590/0037-8682-0167-2022This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.info:eu-repo/semantics/openAccessFilgueiras, Priscilla SoaresCorsini, Camila AmorminoAlmeida, Nathalie Bonatti FrancoPedrosa, Maria Luysa CamargosMiranda, Daniel Alvim Pena deGomes, Sarah Vieira ContinAssis, Jéssica Vieira deSilva, Raphael AntônioMedeiros, Maria Izabella Vieira de Assis Rocha Carvalho deLourenço, Adelina JuniaBicalho, Cecilia Maria FlorencioVilela, Raquel Virgínia RochaJeremias, Wander de JesusFernandes, Gabriel da RochaGrenfell, Rafaella Fortini Queirozengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2023-10-20T19:23:22Zoai:repositorio.ufop.br:123456789/17628Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332023-10-20T19:23:22Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
title |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
spellingShingle |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Filgueiras, Priscilla Soares Covid-19 Rapid test Self-test |
title_short |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
title_full |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
title_fullStr |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
title_full_unstemmed |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
title_sort |
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. |
author |
Filgueiras, Priscilla Soares |
author_facet |
Filgueiras, Priscilla Soares Corsini, Camila Amormino Almeida, Nathalie Bonatti Franco Pedrosa, Maria Luysa Camargos Miranda, Daniel Alvim Pena de Gomes, Sarah Vieira Contin Assis, Jéssica Vieira de Silva, Raphael Antônio Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de Lourenço, Adelina Junia Bicalho, Cecilia Maria Florencio Vilela, Raquel Virgínia Rocha Jeremias, Wander de Jesus Fernandes, Gabriel da Rocha Grenfell, Rafaella Fortini Queiroz |
author_role |
author |
author2 |
Corsini, Camila Amormino Almeida, Nathalie Bonatti Franco Pedrosa, Maria Luysa Camargos Miranda, Daniel Alvim Pena de Gomes, Sarah Vieira Contin Assis, Jéssica Vieira de Silva, Raphael Antônio Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de Lourenço, Adelina Junia Bicalho, Cecilia Maria Florencio Vilela, Raquel Virgínia Rocha Jeremias, Wander de Jesus Fernandes, Gabriel da Rocha Grenfell, Rafaella Fortini Queiroz |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Filgueiras, Priscilla Soares Corsini, Camila Amormino Almeida, Nathalie Bonatti Franco Pedrosa, Maria Luysa Camargos Miranda, Daniel Alvim Pena de Gomes, Sarah Vieira Contin Assis, Jéssica Vieira de Silva, Raphael Antônio Medeiros, Maria Izabella Vieira de Assis Rocha Carvalho de Lourenço, Adelina Junia Bicalho, Cecilia Maria Florencio Vilela, Raquel Virgínia Rocha Jeremias, Wander de Jesus Fernandes, Gabriel da Rocha Grenfell, Rafaella Fortini Queiroz |
dc.subject.por.fl_str_mv |
Covid-19 Rapid test Self-test |
topic |
Covid-19 Rapid test Self-test |
description |
Background: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19 diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is required to guide public health policies and control the speed of transmission and economic recovery. Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen- detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from 609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0. Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of symptom onset. Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of SARS-CoV-2 and contributing to COVID-19 control. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-20T19:23:13Z 2023-10-20T19:23:13Z 2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
FILGUEIRAS, P. S. et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Revista da Sociedade Brasileira de Medicina Tropical, v. 56, artigo e0167, 2023. Disponível em: <https://www.scielo.br/j/rsbmt/a/TyFVt3tgWVdztfdrRXKyykG/>. Acesso em: 01 ago. 2023. 1678-9849 http://www.repositorio.ufop.br/jspui/handle/123456789/17628 https://doi.org/10.1590/0037-8682-0167-2022 |
identifier_str_mv |
FILGUEIRAS, P. S. et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Revista da Sociedade Brasileira de Medicina Tropical, v. 56, artigo e0167, 2023. Disponível em: <https://www.scielo.br/j/rsbmt/a/TyFVt3tgWVdztfdrRXKyykG/>. Acesso em: 01 ago. 2023. 1678-9849 |
url |
http://www.repositorio.ufop.br/jspui/handle/123456789/17628 https://doi.org/10.1590/0037-8682-0167-2022 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
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Universidade Federal de Ouro Preto (UFOP) |
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UFOP |
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UFOP |
reponame_str |
Repositório Institucional da UFOP |
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Repositório Institucional da UFOP |
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Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
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